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Research Output 1998 2019

  • 6759 Citations
  • 49 h-Index
  • 130 Article
  • 1 Chapter
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Article
2019
4 Citations (Scopus)

Acylated anthocyanins derived from purple carrot (: Daucus carota L.) induce elevation of blood flow in rat cremaster arteriole

Tsutsumi, A., Horikoshi, Y., Fushimi, T., Saito, A., Koizumi, R., Fujii, Y., Hu, Q. Q., Hirota, Y., Aizawa, K. & Osakabe, N., 2019 Mar 1, In : Food and Function. 10, 3, p. 1726-1735 10 p.

Research output: Contribution to journalArticle

Daucus carota
carrots
blood flow
cyanidin
glycosides
Open Access
Catechin
Hormones
Messenger RNA
Neurology
cinnamtannin A2
2 Citations (Scopus)

Electrochemical determination with a long-length carbon nanotube electrode of quercetin glucosides in onion, apple peel, and tartary buckwheat

Takahashi, S., Muguruma, H., Osakabe, N., Inoue, H. & Ohsawa, T., 2019 Dec 1, In : Food Chemistry. 300, 125189.

Research output: Contribution to journalArticle

carbon nanotubes
Carbon Nanotubes
buckwheat
Quercetin
Glucosides

Elucidation of the interaction between flavan-3-ols and bovine serum albumin and its effect on their in-vitro cytotoxicity

Fujii, Y., Suhara, Y., Sukikara, Y., Teshima, T., Hirota, Y., Yoshimura, K. & Osakabe, N., 2019 Oct 11, In : Molecules. 24, 20, 3667.

Research output: Contribution to journalArticle

Open Access
Cytotoxicity
Bovine Serum Albumin
albumins
serums
Cell culture
1 Citation (Scopus)

Polyphenol analysis in black tea with a carbon nanotube electrode

Murakami, S., Takahashi, S., Muguruma, H., Osakabe, N., Inoue, H. & Ohsawa, T., 2019 Jan 1, In : Analytical Sciences. 35, 5, p. 529-534 6 p.

Research output: Contribution to journalArticle

Open Access
Carbon Nanotubes
Polyphenols
Electrodes
Pyrogallol
Cyclic voltammetry
5 Citations (Scopus)

Separationless and Adsorptionless Quantification of Individual Catechins in Green Tea with a Carbon Nanotube-Carboxymethylcellulose Electrode

Muguruma, H., Murakami, S., Takahashi, S., Osakabe, N., Inoue, H. & Ohsawa, T., 2019 Jan 23, In : Journal of Agricultural and Food Chemistry. 67, 3, p. 943-954 12 p.

Research output: Contribution to journalArticle

carbon nanotubes
Carboxymethylcellulose Sodium
Carbon Nanotubes
Catechin
carboxymethylcellulose

Simultaneous electrochemical determination of isoquercitrin and epigallocatechingallate at a carbon nanotube electrode

Takahashi, S., Muguruma, H., Osakabe, N., Inoue, H. & Ohsawa, T., 2019 Jan 1, In : Electrochemistry. 87, 4, p. 242-244 3 p.

Research output: Contribution to journalArticle

Open Access
Carbon Nanotubes
Carbon nanotubes
Electrodes
Cyclic voltammetry
isoquercitrin

Synthesis and in vitro evaluation of novel liver X receptor agonists based on naphthoquinone derivatives

Nishioka, T., Endo-Umeda, K., Ito, Y., Shimoda, A., Takeuchi, A., Tode, C., Hirota, Y., Osakabe, N., Makishima, M. & Suhara, Y., 2019 Nov 26, In : Molecules. 24, 23, 4316.

Research output: Contribution to journalArticle

Open Access
Naphthoquinones
liver
Liver
Derivatives
evaluation
2018
3 Citations (Scopus)

Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice

Nakagawa, Y., Ishimura, K., Oya, S., Kamino, M., Fujii, Y., Nanba, F., Toda, T., Ishii, T., Adachi, T., Suhara, Y. & Osakabe, N., 2018 Jul 1, In : PLoS One. 13, 7, e0201203.

Research output: Contribution to journalArticle

Proanthocyanidins
procyanidins
brown adipose tissue
catecholamines
Catecholamines

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice

Hirota, Y., Nakagawa, K., Isomoto, K., Sakaki, T., Kubodera, N., Kamao, M., Osakabe, N., Suhara, Y. & Okano, T., 2018 Oct 1, In : PLoS One. 13, 10, e0199856.

Research output: Contribution to journalArticle

1alpha-hydroxycholecalciferol
vitamin D
bone formation
Bone
bones
5 Citations (Scopus)

Green tea extract and black tea extract differentially influence cecal levels of short-chain fatty acids in rats

Unno, T. & Osakabe, N., 2018 Jan 1, (Accepted/In press) In : Food Science and Nutrition.

Research output: Contribution to journalArticle

black tea
short chain fatty acids
green tea
rats
extracts
6 Citations (Scopus)

Possible mechanisms of postprandial physiological alterations following flavan 3-ol ingestion

Osakabe, N. & Terao, J., 2018 Mar 1, In : Nutrition Reviews. 76, 3, p. 174-186 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Single oral administration of flavan 3-ols induces stress responses monitored with stress hormone elevations in the plasma and paraventricular nucleus

Fujii, Y., Suzuki, K., Hasegawa, Y., Nanba, F., Toda, T., Adachi, T., Taira, S. & Osakabe, N., 2018 Aug 24, In : Neuroscience Letters. 682, p. 106-111 6 p.

Research output: Contribution to journalArticle

2017
2 Citations (Scopus)

Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice

Ito, M., Kudo, N., Miyake, Y., Imai, T., Unno, T., Yamashita, Y., Hirota, Y., Ashida, H. & Osakabe, N., 2017 Nov 1, In : Experimental Gerontology. 98, p. 120-123 4 p.

Research output: Contribution to journalArticle

Muscle
Suspensions
Cocoa
Ligases
Ubiquitin
6 Citations (Scopus)

Substitution at the C-3 position of catechins has an influence on the binding affinities against serum albumin

Ikeda, M., Ueda-Wakagi, M., Hayashibara, K., Kitano, R., Kawase, M., Kaihatsu, K., Kato, N., Suhara, Y., Osakabe, N. & Ashida, H., 2017 Feb 1, In : Molecules. 22, 2, 314.

Research output: Contribution to journalArticle

Catechin
albumins
Serum Albumin
serums
affinity
7 Citations (Scopus)
2016
15 Citations (Scopus)

A single oral dose of flavan-3-ols enhances energy expenditure by sympathetic nerve stimulation in mice

Kamio, N., Suzuki, T., Watanabe, Y., Suhara, Y. & Osakabe, N., 2016 Feb 1, In : Free Radical Biology and Medicine. 91, p. 256-263 8 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Butoxamine
Muscle
Messenger RNA
Proteins
8 Citations (Scopus)

Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice

Ushiama, S., Ishimaru, Y., Narukawa, M., Yoshioka, M., Kozuka, C., Watanabe, N., Tsunoda, M., Osakabe, N., Asakura, T., Masuzaki, H. & Abe, K., 2016 Jan 25, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Catecholamines
Brain
Transcription Factors
Brushes
Medical problems
5 Citations (Scopus)

Onset of a hypotensive effect following ingestion of flavan 3-ols involved in the activation of adrenergic receptors

Saito, A., Inagawa, K., Ebe, R., Fukase, S., Horikoshi, Y., Shibata, M. & Osakabe, N., 2016 Oct 1, In : Free Radical Biology and Medicine. 99, p. 584-592 9 p.

Research output: Contribution to journalArticle

Blood pressure
Adrenergic Receptors
Hemodynamics
Chemical activation
Catechin
10 Citations (Scopus)

The impact of theaflavins on systemic-and microcirculation alterations: The murine and randomized feasibility trials

Saito, A., Nakazato, R., Suhara, Y., Shibata, M., Fukui, T., Ishii, T., Asanuma, T., Mochizuki, K., Nakayama, T. & Osakabe, N., 2016 Jun 1, In : Journal of Nutritional Biochemistry. 32, p. 107-114 8 p.

Research output: Contribution to journalArticle

Microcirculation
Hemodynamics
Blood pressure
Rats
Animals
5 Citations (Scopus)

Visualization of probiotic-mediated Ca2+ signaling in intestinal epithelial cells in vivo

Adachi, T., Kakuta, S., Aihara, Y., Kamiya, T., Watanabe, Y., Osakabe, N., Hazato, N., Miyawaki, A., Yoshikawa, S., Usami, T., Karasuyama, H., Kimoto-Nira, H., Hirayama, K. & Tsuji, N. M., 2016, In : Frontiers in Immunology. 7, DEC, 601.

Research output: Contribution to journalArticle

2015
18 Citations (Scopus)

A single oral administration of theaflavins increases energy expenditure and the expression of metabolic genes

Kudo, N., Arai, Y., Suhara, Y., Ishii, T., Nakayama, T. & Osakabe, N., 2015 Sep 16, In : PLoS One. 10, 9, e0137809.

Research output: Contribution to journalArticle

theaflavins
energy expenditure
oral administration
Genes
genes
2014
8 Citations (Scopus)

Alteration of the systemic and microcirculation by a single oral dose of flavan-3-ols

Ingawa, K., Aruga, N., Matsumura, Y., Shibata, M. & Osakabe, N., 2014 Apr 16, In : PLoS One. 9, 4, e94853.

Research output: Contribution to journalArticle

Microcirculation
Blood pressure
flavanols
Muscle
mouth
20 Citations (Scopus)

Enhancement of energy expenditure following a single oral dose of flavan-3-ols associated with an increase in catecholamine secretion

Matsumura, Y., Nakagawa, Y., Mikome, K., Yamamoto, H. & Osakabe, N., 2014 Nov 6, In : PLoS One. 9, 11, e112180.

Research output: Contribution to journalArticle

Catechin
epicatechin
catecholamines
flavanols
energy expenditure
20 Citations (Scopus)

Flavan-3-ol fraction from cocoa powder promotes mitochondrial biogenesis in skeletal muscle in mice

Watanabe, N., Inagawa, K., Shibata, M. & Osakabe, N., 2014 Apr 5, In : Lipids in Health and Disease. 13, 1, 64.

Research output: Contribution to journalArticle

Cocoa
Blood pressure
Powders
Muscle
Tissue
6 Citations (Scopus)

Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats

Aruga, N., Toriigahara, M., Shibata, M., Ishii, T., Nakayama, T. & Osakabe, N., 2014 Sep 1, In : Journal of Functional Foods. 10, p. 355-363 9 p.

Research output: Contribution to journalArticle

hemodynamics
polyphenols
flavanols
theaflavins
rats
13 Citations (Scopus)

The flavan-3-ol fraction of cocoa powder suppressed changes associated with early-stage metabolic syndrome in high-fat diet-fed rats

Osakabe, N., Hoshi, J., Kudo, N. & Shibata, M., 2014 Apr 17, (Accepted/In press) In : Life Sciences.

Research output: Contribution to journalArticle

Cocoa
Nutrition
Powders
Rats
Fats
2013
24 Citations (Scopus)

Flavan 3-ols improve metabolic syndrome risk factors: Evidence and mechanisms

Osakabe, N., 2013 May, In : Journal of Clinical Biochemistry and Nutrition. 52, 3, p. 186-192 7 p.

Research output: Contribution to journalArticle

Catechin
Proanthocyanidins
Oligomers
Monomers
2012
4 Citations (Scopus)
Cocoa
Nutrition
Rats
Fats
Acetylcholine
1 Citation (Scopus)
Theobroma cacao
high fat diet
polyphenols
flavanols
rats
32 Citations (Scopus)

Cacao polyphenols influence the regulation of apolipoprotein in hepg2 and caco2 cells

Yasuda, A., Natsume, M., Osakabe, N., Kawahata, K. & Koga, J., 2011 Feb 23, In : Journal of Agricultural and Food Chemistry. 59, 4, p. 1470-1476 7 p.

Research output: Contribution to journalArticle

apolipoproteins
Apolipoproteins
Polyphenols
Cocoa
polyphenols
2010
15 Citations (Scopus)

Procyanidins in Theobroma cacao reduce plasma cholesterol levels in high cholesterol-fed rats

Osakabe, N. & Yamagishi, M., 2009 Sep, In : Journal of Clinical Biochemistry and Nutrition. 45, 2, p. 131-136 6 p.

Research output: Contribution to journalArticle

Proanthocyanidins
Rats
Cholesterol
Nutrition
Plasmas
15 Citations (Scopus)

Procyanidins in Theobroma cacao Reduce Plasma Cholesterol Levels in High Cholesterol-Fed Rats.

Osakabe, N. & Yamagishi, M., 2009 Aug 28, In : Jounal of Clinical Biochemstry and Nutrition.. 45, p. 131-136

Research output: Contribution to journalArticle

2008
7 Citations (Scopus)

Cacao liquor proanthocyanidins inhibit lung injury induced by diesel exhaust particles

Yasuda, A., Takano, H., Osakabe, N., Sanbongi, C., Fukuda, K., Natsume, M., Yanagisawa, R., Inoue, K., Kato, Y., Osawa, T. & Yoshikawa, T., 2008 Apr, In : International Journal of Immunopathology and Pharmacology. 21, 2, p. 279-288 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Cacao liquor proanthocyanidins inhibit lung injury induced by diesel exhaust particles.

Yasuda, A., Yoshikawa, A. Y. H. N. C. & Osakabe, N., 2008 Jul 1, In : International Jounal of Immunopathological Pharmacolgy. 21, p. 279-288

Research output: Contribution to journalArticle

12 Citations (Scopus)

Cacao polyphenol extract suppresses transformation of an aryl hydrocarbon receptor in C57BL/6 mice

Mukai, R., Fukuda, I., Nishiumi, S., Natsume, M., Osakabe, N., Yoshida, K. I. & Ashida, H., 2008 Nov 12, In : Journal of Agricultural and Food Chemistry. 56, 21, p. 10399-10405 7 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Polyphenols
hydrocarbons
polyphenols
Methylcholanthrene
12 Citations (Scopus)

Cacao polyphenol extract suppresses transformation of an aryl hydrocarbon receptor in C57BL/6 mice.

Mukai, R., Ashida, R. M. I. S. M. N. & Osakabe, N., 2008 Nov 1, In : Jounal of Agricalural Food Chemistry. 56, p. 10399-10405

Research output: Contribution to journalArticle

11 Citations (Scopus)

Effects of cacao liquor polyphenols on cardiovascular and autonomic nervous functions in hypercholesterolaemic rabbits

Akita, M., Kuwahara, M., Itoh, F., Nakano, Y., Osakabe, N., Kurosawa, T. & Tsubone, H., 2008 Dec, In : Basic and Clinical Pharmacology and Toxicology. 103, 6, p. 581-587 7 p.

Research output: Contribution to journalArticle

Polyphenols
Nutrition
Blood pressure
Animals
Aging of materials
11 Citations (Scopus)

Effects of cacao liquor polyphenols on cardiovascular and autonomic nervous functions in hypercholesterolaemic rabbits.

Akita, M., Tsubone, M. AM. F. Y. N. & Osakabe, N., 2008 Dec 1, In : Basic Clinical Pharmacology and Toxicology.. 103, p. 581-587

Research output: Contribution to journalArticle

10 Citations (Scopus)

Inhibitory effects of conjugated epicatechin metabolites on peroxynitrite-mediated nitrotyrosine formation

Natsume, M., Osakabe, N., Yasuda, A., Osawa, T. & Terao, J., 2008 Jan, In : Journal of Clinical Biochemistry and Nutrition. 42, 1, p. 50-53 4 p.

Research output: Contribution to journalArticle

Peroxynitrous Acid
Catechin
epicatechin
Metabolites
metabolites
10 Citations (Scopus)

Inhibitory Effects of Conjugated Epicatechin Metabolites on Peroxynitrite-mediated Nitrotyrosine Formation.

Natsume, M., Terao, M. N. N. A. T. J. & Osakabe, N., 2008 Jan 1, In : Jounal of Clinical Biochemistry and Nutririon.. 42, p. 50-53

Research output: Contribution to journalArticle

2007
191 Citations (Scopus)

Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans

Baba, S., Osakabe, N., Kato, Y., Natsume, M., Yasuda, A., Kido, T., Fukuda, K., Muto, Y. & Kondo, K., 2007 Mar 1, In : American Journal of Clinical Nutrition. 85, 3, p. 709-717 9 p.

Research output: Contribution to journalArticle

cocoa powder
high density lipoprotein cholesterol
polyphenols
oxidation
blood lipids
191 Citations (Scopus)
81 Citations (Scopus)

Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice

Tomaru, M., Takano, H., Osakabe, N., Yasuda, A., Inoue, K. I., Yanagisawa, R., Ohwatari, T. & Uematsu, H., 2007 Apr, In : Nutrition. 23, 4, p. 351-355 5 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)

Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder

Baba, S., Natsume, M., Yasuda, A., Nakamura, Y., Tamura, T., Osakabe, N., Kanegae, M. & Kondo, K., 2007 Jun, In : Journal of Nutrition. 137, 6, p. 1436-1441 6 p.

Research output: Contribution to journalArticle

cocoa powder
low density lipoprotein cholesterol
high density lipoprotein cholesterol
polyphenols
beverages
141 Citations (Scopus)

Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder.

S., B., M., N., A., Y., Y., N., T., T., M., K., K., K., N., O. & Osakabe, N., 2007 Jan 1, In : J. Nutr.. 137, p. 1436-1441

Research output: Contribution to journalArticle