• 6824 Citations
  • 49 h-Index
19982019

Research output per year

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Research Output

  • 6824 Citations
  • 49 h-Index
  • 128 Article
  • 2 Review article
  • 1 Chapter
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Article
2019

Acylated anthocyanins derived from purple carrot (: Daucus carota L.) induce elevation of blood flow in rat cremaster arteriole

Tsutsumi, A., Horikoshi, Y., Fushimi, T., Saito, A., Koizumi, R., Fujii, Y., Hu, Q. Q., Hirota, Y., Aizawa, K. & Osakabe, N., 2019 Mar 1, In : Food and Function. 10, 3, p. 1726-1735 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
Open Access

Electrochemical determination with a long-length carbon nanotube electrode of quercetin glucosides in onion, apple peel, and tartary buckwheat

Takahashi, S., Muguruma, H., Osakabe, N., Inoue, H. & Ohsawa, T., 2019 Dec 1, In : Food Chemistry. 300, 125189.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Elucidation of the interaction between flavan-3-ols and bovine serum albumin and its effect on their in-vitro cytotoxicity

Fujii, Y., Suhara, Y., Sukikara, Y., Teshima, T., Hirota, Y., Yoshimura, K. & Osakabe, N., 2019 Oct 11, In : Molecules. 24, 20, 3667.

Research output: Contribution to journalArticle

Open Access

Polyphenol analysis in black tea with a carbon nanotube electrode

Murakami, S., Takahashi, S., Muguruma, H., Osakabe, N., Inoue, H. & Ohsawa, T., 2019 Jan 1, In : Analytical Sciences. 35, 5, p. 529-534 6 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Separationless and Adsorptionless Quantification of Individual Catechins in Green Tea with a Carbon Nanotube-Carboxymethylcellulose Electrode

Muguruma, H., Murakami, S., Takahashi, S., Osakabe, N., Inoue, H. & Ohsawa, T., 2019 Jan 23, In : Journal of Agricultural and Food Chemistry. 67, 3, p. 943-954 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Simultaneous electrochemical determination of isoquercitrin and epigallocatechingallate at a carbon nanotube electrode

Takahashi, S., Muguruma, H., Osakabe, N., Inoue, H. & Ohsawa, T., 2019 Jan 1, In : Electrochemistry. 87, 4, p. 242-244 3 p.

Research output: Contribution to journalArticle

Open Access

Synthesis and in vitro evaluation of novel liver X receptor agonists based on naphthoquinone derivatives

Nishioka, T., Endo-Umeda, K., Ito, Y., Shimoda, A., Takeuchi, A., Tode, C., Hirota, Y., Osakabe, N., Makishima, M. & Suhara, Y., 2019 Nov 26, In : Molecules. 24, 23, 4316.

Research output: Contribution to journalArticle

Open Access
2018

Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice

Nakagawa, Y., Ishimura, K., Oya, S., Kamino, M., Fujii, Y., Nanba, F., Toda, T., Ishii, T., Adachi, T., Suhara, Y. & Osakabe, N., 2018 Jul 1, In : PLoS One. 13, 7, e0201203.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice

Hirota, Y., Nakagawa, K., Isomoto, K., Sakaki, T., Kubodera, N., Kamao, M., Osakabe, N., Suhara, Y. & Okano, T., 2018 Oct 1, In : PLoS One. 13, 10, e0199856.

Research output: Contribution to journalArticle

Green tea extract and black tea extract differentially influence cecal levels of short-chain fatty acids in rats

Unno, T. & Osakabe, N., 2018 Jan 1, (Accepted/In press) In : Food Science and Nutrition.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Possible mechanisms of postprandial physiological alterations following flavan 3-ol ingestion

Osakabe, N. & Terao, J., 2018 Mar 1, In : Nutrition Reviews. 76, 3, p. 174-186 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Single oral administration of flavan 3-ols induces stress responses monitored with stress hormone elevations in the plasma and paraventricular nucleus

Fujii, Y., Suzuki, K., Hasegawa, Y., Nanba, F., Toda, T., Adachi, T., Taira, S. & Osakabe, N., 2018 Aug 24, In : Neuroscience Letters. 682, p. 106-111 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice

Ito, M., Kudo, N., Miyake, Y., Imai, T., Unno, T., Yamashita, Y., Hirota, Y., Ashida, H. & Osakabe, N., 2017 Nov 1, In : Experimental Gerontology. 98, p. 120-123 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Substitution at the C-3 position of catechins has an influence on the binding affinities against serum albumin

Ikeda, M., Ueda-Wakagi, M., Hayashibara, K., Kitano, R., Kawase, M., Kaihatsu, K., Kato, N., Suhara, Y., Osakabe, N. & Ashida, H., 2017 Feb 1, In : Molecules. 22, 2, 314.

Research output: Contribution to journalArticle

6 Citations (Scopus)
8 Citations (Scopus)
2016

A single oral dose of flavan-3-ols enhances energy expenditure by sympathetic nerve stimulation in mice

Kamio, N., Suzuki, T., Watanabe, Y., Suhara, Y. & Osakabe, N., 2016 Feb 1, In : Free Radical Biology and Medicine. 91, p. 256-263 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice

Ushiama, S., Ishimaru, Y., Narukawa, M., Yoshioka, M., Kozuka, C., Watanabe, N., Tsunoda, M., Osakabe, N., Asakura, T., Masuzaki, H. & Abe, K., 2016 Jan 25, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Onset of a hypotensive effect following ingestion of flavan 3-ols involved in the activation of adrenergic receptors

Saito, A., Inagawa, K., Ebe, R., Fukase, S., Horikoshi, Y., Shibata, M. & Osakabe, N., 2016 Oct 1, In : Free Radical Biology and Medicine. 99, p. 584-592 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The impact of theaflavins on systemic-and microcirculation alterations: The murine and randomized feasibility trials

Saito, A., Nakazato, R., Suhara, Y., Shibata, M., Fukui, T., Ishii, T., Asanuma, T., Mochizuki, K., Nakayama, T. & Osakabe, N., 2016 Jun 1, In : Journal of Nutritional Biochemistry. 32, p. 107-114 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Visualization of probiotic-mediated Ca2+ signaling in intestinal epithelial cells in vivo

Adachi, T., Kakuta, S., Aihara, Y., Kamiya, T., Watanabe, Y., Osakabe, N., Hazato, N., Miyawaki, A., Yoshikawa, S., Usami, T., Karasuyama, H., Kimoto-Nira, H., Hirayama, K. & Tsuji, N. M., 2016, In : Frontiers in Immunology. 7, DEC, 601.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2015

A single oral administration of theaflavins increases energy expenditure and the expression of metabolic genes

Kudo, N., Arai, Y., Suhara, Y., Ishii, T., Nakayama, T. & Osakabe, N., 2015 Sep 16, In : PLoS One. 10, 9, e0137809.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2014

Alteration of the systemic and microcirculation by a single oral dose of flavan-3-ols

Ingawa, K., Aruga, N., Matsumura, Y., Shibata, M. & Osakabe, N., 2014 Apr 16, In : PLoS ONE. 9, 4, e94853.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Enhancement of energy expenditure following a single oral dose of flavan-3-ols associated with an increase in catecholamine secretion

Matsumura, Y., Nakagawa, Y., Mikome, K., Yamamoto, H. & Osakabe, N., 2014 Nov 6, In : PLoS ONE. 9, 11, e112180.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Flavan-3-ol fraction from cocoa powder promotes mitochondrial biogenesis in skeletal muscle in mice

Watanabe, N., Inagawa, K., Shibata, M. & Osakabe, N., 2014 Apr 5, In : Lipids in Health and Disease. 13, 1, 64.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats

Aruga, N., Toriigahara, M., Shibata, M., Ishii, T., Nakayama, T. & Osakabe, N., 2014 Sep 1, In : Journal of Functional Foods. 10, p. 355-363 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The flavan-3-ol fraction of cocoa powder suppressed changes associated with early-stage metabolic syndrome in high-fat diet-fed rats

Osakabe, N., Hoshi, J., Kudo, N. & Shibata, M., 2014 Jul 22, In : Life Sciences. 114, 1, p. 51-56 6 p., 14113.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2012
4 Citations (Scopus)
1 Citation (Scopus)

Cacao polyphenols influence the regulation of apolipoprotein in hepg2 and caco2 cells

Yasuda, A., Natsume, M., Osakabe, N., Kawahata, K. & Koga, J., 2011 Feb 23, In : Journal of Agricultural and Food Chemistry. 59, 4, p. 1470-1476 7 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2010

Procyanidins in Theobroma cacao reduce plasma cholesterol levels in high cholesterol-fed rats

Osakabe, N. & Yamagishi, M., 2009 Sep 1, In : Journal of Clinical Biochemistry and Nutrition. 45, 2, p. 131-136 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Procyanidins in Theobroma cacao Reduce Plasma Cholesterol Levels in High Cholesterol-Fed Rats.

Osakabe, N. & Yamagishi, M., 2009 Aug 28, In : Jounal of Clinical Biochemstry and Nutrition.. 45, p. 131-136

Research output: Contribution to journalArticle

15 Citations (Scopus)
2008

Cacao liquor proanthocyanidins inhibit lung injury induced by diesel exhaust particles

Yasuda, A., Takano, H., Osakabe, N., Sanbongi, C., Fukuda, K., Natsume, M., Yanagisawa, R., Inoue, K., Kato, Y., Osawa, T. & Yoshikawa, T., 2008 Jan 1, In : International Journal of Immunopathology and Pharmacology. 21, 2, p. 279-288 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Cacao liquor proanthocyanidins inhibit lung injury induced by diesel exhaust particles.

Yasuda, A., Yoshikawa, A. Y. H. N. C. & Osakabe, N., 2008 Jul 1, In : International Jounal of Immunopathological Pharmacolgy. 21, p. 279-288

Research output: Contribution to journalArticle

7 Citations (Scopus)

Cacao polyphenol extract suppresses transformation of an aryl hydrocarbon receptor in C57BL/6 mice

Mukai, R., Fukuda, I., Nishiumi, S., Natsume, M., Osakabe, N., Yoshida, K. I. & Ashida, H., 2008 Nov 12, In : Journal of Agricultural and Food Chemistry. 56, 21, p. 10399-10405 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Cacao polyphenol extract suppresses transformation of an aryl hydrocarbon receptor in C57BL/6 mice.

Mukai, R., Ashida, R. M. I. S. M. N. & Osakabe, N., 2008 Nov 1, In : Jounal of Agricalural Food Chemistry. 56, p. 10399-10405

Research output: Contribution to journalArticle

12 Citations (Scopus)

Effects of cacao liquor polyphenols on cardiovascular and autonomic nervous functions in hypercholesterolaemic rabbits

Akita, M., Kuwahara, M., Itoh, F., Nakano, Y., Osakabe, N., Kurosawa, T. & Tsubone, H., 2008 Dec 1, In : Basic and Clinical Pharmacology and Toxicology. 103, 6, p. 581-587 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Effects of cacao liquor polyphenols on cardiovascular and autonomic nervous functions in hypercholesterolaemic rabbits.

Akita, M., Tsubone, M. AM. F. Y. N. & Osakabe, N., 2008 Dec 1, In : Basic Clinical Pharmacology and Toxicology.. 103, p. 581-587

Research output: Contribution to journalArticle

11 Citations (Scopus)

Inhibitory effects of conjugated epicatechin metabolites on peroxynitrite-mediated nitrotyrosine formation

Natsume, M., Osakabe, N., Yasuda, A., Osawa, T. & Terao, J., 2008 Jan 1, In : Journal of Clinical Biochemistry and Nutrition. 42, 1, p. 50-53 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Inhibitory Effects of Conjugated Epicatechin Metabolites on Peroxynitrite-mediated Nitrotyrosine Formation.

Natsume, M., Terao, M. N. N. A. T. J. & Osakabe, N., 2008 Jan 1, In : Jounal of Clinical Biochemistry and Nutririon.. 42, p. 50-53

Research output: Contribution to journalArticle

10 Citations (Scopus)
2007

Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans

Baba, S., Osakabe, N., Kato, Y., Natsume, M., Yasuda, A., Kido, T., Fukuda, K., Muto, Y. & Kondo, K., 2007 Mar 1, In : American Journal of Clinical Nutrition. 85, 3, p. 709-717 9 p.

Research output: Contribution to journalArticle

193 Citations (Scopus)
193 Citations (Scopus)

Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice

Tomaru, M., Takano, H., Osakabe, N., Yasuda, A., Inoue, K. I., Yanagisawa, R., Ohwatari, T. & Uematsu, H., 2007 Apr 1, In : Nutrition. 23, 4, p. 351-355 5 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder

Baba, S., Natsume, M., Yasuda, A., Nakamura, Y., Tamura, T., Osakabe, N., Kanegae, M. & Kondo, K., 2007 Jun 1, In : Journal of Nutrition. 137, 6, p. 1436-1441 6 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)

Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder.

S., B., M., N., A., Y., Y., N., T., T., M., K., K., K., N., O. & Osakabe, N., 2007 Jan 1, In : J. Nutr.. 137, p. 1436-1441

Research output: Contribution to journalArticle

146 Citations (Scopus)

Pulmonary exposure to diesel exhaust particles enhances fatty change of the liver in obese diabetic mice

Tomaru, M., Takano, H., Inoue, K. I., Yanagisawa, R., Osakabe, N., Yasuda, A., Shimada, A., Kato, Y. & Uematsu, H., 2007 Jan 1, In : International Journal of Molecular Medicine. 19, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)