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Research Output 1998 2019

  • 6790 Citations
  • 49 h-Index
  • 130 Article
  • 1 Chapter
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Article
1998
193 Citations (Scopus)

Antioxidative Polyphenols Isolated from Theobroma cacao

Sanbongi, C., Osakabe, N., Natsume, M., Takizawa, T., Gomi, S. & Osawa, T., 1998 Feb, In : Journal of Agricultural and Food Chemistry. 46, 2, p. 454-457 4 p.

Research output: Contribution to journalArticle

Theobroma cacao
Quercetin
Glucosides
chocolate
Polyphenols
193 Citations (Scopus)

Antioxidative Polyphenols Isolated from Theobroma cacao.

C., S., N, O., M., N., T., T., S., G., T., O. & Osakabe, N., 1998 Feb 1, In : J. Agric .Food Chem.. 46, p. 454-457

Research output: Contribution to journalArticle

52 Citations (Scopus)

Effects of Polyphenol Substances Derived from Theobroma cacao on Gastric Mucosal Lesion Induced by Ethanol

Osakabe, N., Sanbongi, C., Yamagishi, M., Takizawa, T. & Osawa, T., 1998 Aug, In : Bioscience, Biotechnology and Biochemistry. 62, 8, p. 1535-1538 4 p.

Research output: Contribution to journalArticle

chocolate liquor
Theobroma cacao
Polyphenols
lesions (animal)
polyphenols
52 Citations (Scopus)

Effects of polyphenol substances derived from Theobroma cacao on gastric mucosal lesion induced by ethanol.

N, O., Sanbongi, S., C., C., M., Y., T., T., T., O. & Osakabe, N., 1998 Aug 1, In : Biosci. Biotechnol. Biochem.. 62, p. 1535-1538

Research output: Contribution to journalArticle

74 Citations (Scopus)

The antioxidative substances in cacao liquor

Osakabe, N., Yamagishi, M., Sanbongi, C., Natsume, M., Takizawa, T. & Osawa, T., 1998, In : Journal of Nutritional Science and Vitaminology. 44, 2, p. 313-321 9 p.

Research output: Contribution to journalArticle

chocolate liquor
epicatechin
catechin
polyphenols
chocolate
74 Citations (Scopus)

The antioxidative substances in cacao liquor.

N, O., M., Y., C., S., M., N., T., T., T., O. & Osakabe, N., 1998 Jan 1, In : J. Nutr. Sci. Vitaminol.. 44, p. 313-321

Research output: Contribution to journalArticle

1999

Analyses of Polyphenol Constituents in Defatted Cacao Liquor and Antioxidative Effects on Human LDL in vitro

Natsume, M., Osakabe, N., Takizawa, T., Nakamura, T., Miyake, H., Ito, H., Hatano, T. & Yoshida, T., 1999 Dec 5, In : Default journal.

Research output: Contribution to journalArticle

2000

Absorption and Urinary Excretion of (-)-Epicatechin after Administration of Different Levels of Cocoa Powder or (-)-Epicatechin in Rats.

S., B., N, O., M, N., Y., M., T., T., J., T. & Osakabe, N., 2000 Dec 1, In : J. Agric. Food Chem.. 49, p. 6050-6056

Research output: Contribution to journalArticle

173 Citations (Scopus)

Analyses of Polyphenols in Cacao Liquor, Cocoa, and Chocolate by Normal-Phase and Reversed-Phase HPLC

Natsume, M., Osakabe, N., Yamagishi, M., Takizawa, T., Nakamura, T., Miyatake, H., Hatano, T. & Yoshida, T., 2000 Dec, In : Bioscience, Biotechnology and Biochemistry. 64, 12, p. 2581-2587 7 p.

Research output: Contribution to journalArticle

chocolate liquor
Cocoa
cocoa (beverage)
Catechin
Polyphenols
173 Citations (Scopus)

Analyses of polyphenols in cacao liquor, cocoa, and chocolate by normal- phase and reversed-phase HPLC.

M, N., N, O., M., Y., T., T., T., N., H., M., T., H., T., Y. & Osakabe, N., 2000 Dec 1, In : Biosci. Biotechnol. Biochem.. 33, p. 2581-2587

Research output: Contribution to journalArticle

35 Citations (Scopus)

Antimutagenic activity of cacao: Inhibitory effect of cacao liquor polyphenols on the mutagenic action of heterocyclic amines

Yamagishi, M., Natsume, M., Nagaki, A., Adachi, T., Osakabe, N., Takizawa, T., Kumon, H. & Osawa, T., 2000, In : Journal of Agricultural and Food Chemistry. 48, 10, p. 5074-5078 5 p.

Research output: Contribution to journalArticle

chocolate liquor
heterocyclic amines
antimutagenic activity
Polyphenols
Amines
35 Citations (Scopus)

Antimutagenic activity of cacao: inhibitory effect of cacao liquor polyphenols on the mutagenic action of heterocyclic amines.

M., Y., M., N., A., N., T., A., N, O., T., T., H., K., T., O. & Osakabe, N., 2000 Oct 1, In : J..Agric. Food Chem.. 48, p. 5074-5078

Research output: Contribution to journalArticle

28 Citations (Scopus)

Antioxidant effects of polyphenols in chocolate on low-density lipoprotein both in vitro and ex vivo

Hirano, R., Osakabe, N., Iwamoto, T., Matsumoto, A., Natsume, M., Takizawa, T., Igarashi, O., Itakura, H. & Kondo, K., 2000, In : Journal of Nutritional Science and Vitaminology. 46, 4, p. 199-204 6 p.

Research output: Contribution to journalArticle

chocolate
low density lipoprotein
chocolate liquor
polyphenols
antioxidants
28 Citations (Scopus)

Antioxidant effects of polyphenols in chocolate on low-density lipoprotein both in vitro and ex vivo.

R., H., N, O., A, I., A, M., M., N., T., T., O., I., K., K., H., I. & Osakabe, N., 2000 Aug 1, In : J. Nutr. Sci. Vitaminol.. 46, p. 199-204

Research output: Contribution to journalArticle

8 Citations (Scopus)

Antioxidative polyphenolic substances in cacao liquor

Osakabe, N., Yamagishi, M., Natsume, M., Takizawa, T., Nakamura, T. & Osawa, T., 2000, In : ACS Symposium Series. 754, p. 88-101 14 p.

Research output: Contribution to journalArticle

Cocoa
Glycosides
Oxidative stress
Catechin
Vitamins
198 Citations (Scopus)

Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers

Baba, S., Osakabe, N., Yasuda, A., Natsume, M., Takizawa, T., Nakamura, T. & Terao, J., 2000, In : Free Radical Research. 33, 5, p. 635-641 7 p.

Research output: Contribution to journalArticle

Cocoa
Catechin
Metabolites
Plasmas
Glucuronides
198 Citations (Scopus)

Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers.

S., B., N, O., A, Y., M., N., T., T., T., N., J., T. & Osakabe, N., 2000 Nov 1, In : Free Radic. Res.. 33, p. 635-641

Research output: Contribution to journalArticle

70 Citations (Scopus)

Cocoa powder enhances the level of antioxidative activity in rat plasma

Baba, S., Osakabe, N., Natsume, M., Yasuda, A., Takizawa, T., Nakamura, T. & Terao, J., 2000, In : British Journal of Nutrition. 84, 5, p. 673-680 8 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Cocoa powder enhances the level of antioxidative activity in rat plasma.

S, B., N, O., M., N., A., Y., T, T., T., N., J., T. & Osakabe, N., 2000 Jan 1, In : Br. J. Nutr.. 84, p. 673-680

Research output: Contribution to journalArticle

33 Citations (Scopus)

Effects of cacao liquor polyphenols on the susceptibility of low-density lipoprotein to oxidation in hypercholesterolemic rabbits.

Osakabe, N., Natsume, M., Adachi, T., Yamagishi, M., Hirano, R., Takizawa, T., Itakura, H. & Kondo, K., 2000, In : Journal of Atherosclerosis and Thrombosis. 7, 3, p. 164-168 5 p.

Research output: Contribution to journalArticle

Polyphenols
LDL Lipoproteins
Oxidation
Thiobarbituric Acid Reactive Substances
Nutrition
2001
90 Citations (Scopus)

Absorption and urinary excretion of (-)-epicatechin after administration of different levels of cocoa powder or (-)-epicatechin in rats

Baba, S., Osakabe, N., Natsume, M., Muto, Y., Takizawa, T. & Terao, J., 2001, In : Journal of Agricultural and Food Chemistry. 49, 12, p. 6050-6056 7 p.

Research output: Contribution to journalArticle

Cocoa
cocoa powder
Catechin
epicatechin
Powders

Analysis of polyphenol constituents in cocoa and chocolate.

M., N., N, O., T., T., T., N., H., M., T., H., T., Y. & Osakabe, N., 2001 Jan 1, In : ACS Symposium Series. 754, p. 180-198

Research output: Contribution to journalArticle

28 Citations (Scopus)

Anticlastogenic activity of cacao: Inhibitory effect of cacao liquor polyphenols against mitomycin C-induced DNA damage

Yamagishi, M., Osakabe, N., Natsume, M., Adachi, T., Takizawa, T., Kumon, H. & Osawa, T., 2001, In : Food and Chemical Toxicology. 39, 12, p. 1279-1283 5 p.

Research output: Contribution to journalArticle

chocolate liquor
mitomycin
antimutagenic activity
Polyphenols
Mitomycin
28 Citations (Scopus)

Anticlastogenic activity of cacao: inhibitory effect of cacao liquor polyphenols against mitomycin C-induced DNA damage.

M., Y., N, O., M., N., T., A., T., T., H., K., T., O. & Osakabe, N., 2001 Dec 1, In : Food Chem. Toxicol.. 39, p. 1279-1283

Research output: Contribution to journalArticle

Antioxidative polyphenols in Theobroma cacao

N, O., N., O., M., N., A., Y., T., T., T., H., T., Y., T., O., K., K. & Osakabe, N., 2001 Apr 1, In : Default journal.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Cacao liquor polyphenols reduce oxidative stress without maintaining alpha-tocopherol levels in rats fed a vitamin E-deficient diet.

N, O., M., Y., T., T., T., O. & Osakabe, N., 2001 Jan 1, In : Lipids.. 36, p. 67-71

Research output: Contribution to journalArticle

20 Citations (Scopus)

Cacao liquor polyphenols reduce oxidative stress without maintaining α-tocopherol levels in rats fed a vitamin E-deficient diet

Yamagishi, M., Osakabe, N., Takizawa, T. & Osawa, T., 2001, In : Lipids. 36, 1, p. 67-71 5 p.

Research output: Contribution to journalArticle

chocolate liquor
Oxidative stress
Tocopherols
Polyphenols
Nutrition
108 Citations (Scopus)

Daily cocoa intake reduces the susceptibility of low-density lipoprotein to oxidation as demonstrated in healthy human volunteers

Osakabe, N., Baba, S., Yasuda, A., Iwamoto, T., Kamiyama, M., Takizawa, T., Itakura, H. & Kondo, K., 2001, In : Free Radical Research. 34, 1, p. 93-99 7 p.

Research output: Contribution to journalArticle

Cocoa
LDL Lipoproteins
Powders
Oxidation
Sugars
108 Citations (Scopus)

Daily cocoa intake reduces the susceptibility of low-density lipoprotein to oxidation as demonstrated in healthy human volunteers.

N, O., S., B., A., Y., T., I., M., K., T., T., K., K., H., I. & Osakabe, N., 2001 Jan 1, In : Free Radic. Res.. 34, p. 93-99

Research output: Contribution to journalArticle

168 Citations (Scopus)

In vivo comparison of the bioavailability of (+)-catechin, (-)-epicatechin and their mixture in orally administered rats

Baba, S., Osakabe, N., Natsume, M., Muto, Y., Takizawa, T. & Terao, J., 2001, In : Journal of Nutrition. 131, 11, p. 2885-2891 7 p.

Research output: Contribution to journalArticle

epicatechin
catechin
bioavailability
metabolites
rats
4 Citations (Scopus)

The inhibitory effect of cacao liquor crude polyphenols (CLP) on experimental arteriosclerosis with calcification in rat soft tissue

Horiuchi, M., Osakabe, N., Takizawa, T. & Seyama, Y., 2001, In : Journal of Health Science. 47, 2, p. 208-212 5 p.

Research output: Contribution to journalArticle

Polyphenols
Vitamin E
Rats
Tissue
Nutrition
4 Citations (Scopus)

The inhibitory effect of cacao liquor crude polyphenols (CLP) on experimental arteriosclerosis with calcification in rat soft tissue.

M., H., N, O., T., T., Y., S. & Osakabe, N., 2001 Mar 1, In : J. Health Sci.. 47, p. 208-212

Research output: Contribution to journalArticle

2002
189 Citations (Scopus)

Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats.

S., B., N, O., M., N., J., T. & Osakabe, N., 2002 Jul 1, In : Free Radic. Biol. Med.. 33, p. 142-148

Research output: Contribution to journalArticle

189 Citations (Scopus)

Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

Baba, S., Osakabe, N., Natsume, M. & Terao, J., 2002 Jul 1, In : Free Radical Biology and Medicine. 33, 1, p. 142-148 7 p.

Research output: Contribution to journalArticle

Catechin
Rats
Plasmas
Lipid Peroxides
Copper
2 Citations (Scopus)

Analysis of polyphenol constituents in cocoa and chocolate

Natsume, M., Osakabe, N., Takizawa, T., Nakamura, T., Miyatake, H., Hatano, T. & Yoshida, T., 2002, In : ACS Symposium Series. 803, p. 180-213 34 p.

Research output: Contribution to journalArticle

Cocoa
Catechin
Polyphenols
Antioxidants
Oligomers
58 Citations (Scopus)

Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and low-density lipoprotein from oxidation in vitro.

N, O., A., Y., M., N., Takizawa, T., T, T., J., T., K., K. & Osakabe, N., 2002 Jan 1, In : Exp. Biol. Med.. 227, p. 51-56

Research output: Contribution to journalArticle

58 Citations (Scopus)

Catechins and their oligomers linked by C4 → C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro

Osakabe, N., Yasuda, A., Natsume, M., Takizawa, T., Terao, J. & Kondo, K., 2002 Jan, In : Experimental Biology and Medicine. 227, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

Catechin
Polyphenols
LDL Lipoproteins
Oligomers
Oxidation
46 Citations (Scopus)

Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats

Yamagishi, M., Natsume, M., Osakabe, N., Nakamura, H., Furukawa, F., Imazawa, T., Nishikawa, A. & Hirose, M., 2002 Nov 28, In : Cancer Letters. 185, 2, p. 123-130 8 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects

Hatano, T., Miyatake, H., Natsume, M., Osakabe, N., Takizawa, T., Ito, H. & Yoshida, T., 2002 Apr 8, In : Phytochemistry. 59, 7, p. 749-758 10 p.

Research output: Contribution to journalArticle

chocolate liquor
Polyphenols
Glycosides
proanthocyanidins
glycosides
149 Citations (Scopus)

Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects.

T., H., H., M., M., N., N, O., T, T., H., I., T., Y. & Osakabe, N., 2002 Apr 1, In : Phytochemistry. 59, p. 749-758

Research output: Contribution to journalArticle

137 Citations (Scopus)

Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-GalN)-sensitized mice

Osakabe, N., Yasuda, A., Natsume, M., Sanbongi, C., Kato, Y., Osawa, T. & Yoshikawa, T., 2002 Sep 15, In : Free Radical Biology and Medicine. 33, 6, p. 798-806 9 p.

Research output: Contribution to journalArticle

Galactosamine
Liver
Lipopolysaccharides
Tumor Necrosis Factor-alpha
Plasmas
137 Citations (Scopus)
2003

(-)-Epicatechin metabolites modulate in gene expression of oxidazed LDL stimulated human umbilical vein endothelial cells (HUVEC)

Osakabe, N., Fukasawa, T., Yasuda1, A., Matsumoto, I., Abe, K. & Osawa, T., 2003 Dec 5, In : Default journal.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model

Yamagishi, M., Natsume, M., Osakabe, N., Okazaki, K., Furukawa, F., Imazawa, T., Nishikawa, A. & Hirose, M., 2003 Feb 28, In : Cancer Letters. 191, 1, p. 49-57 9 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.

Yamagishi, Y., M., M., M., N., N, O., K, O., F, F., T., I., A, N., M., H. & Osakabe, N., 2003 Feb 1, In : Cancer Lett.. 191, p. 49-57

Research output: Contribution to journalArticle

Physiological activities of polyphenols in Theobroma cacao~Cacao polyphenols prevent atherosclerosis~

Osakabe, N., Natsume, M., Baba, S., Yasuda, A., Yamagishi, M., Terao, J. & Osawa, T., 2003 Nov 15, In : 1st International Conference on Polyphenols and Health(ICPH).

Research output: Contribution to journalArticle

88 Citations (Scopus)

Rosmarinic acid inhibits lung injury induced by diesel exhaust particles

Sanbongi, C., Takano, H., Osakabe, N., Sasa, N., Natsume, M., Yanagisawa, R., Inoue, K. I., Kato, Y., Osawa, T. & Yoshikawa, T., 2003 Apr 15, In : Free Radical Biology and Medicine. 34, 8, p. 1060-1069 10 p.

Research output: Contribution to journalArticle

Vehicle Emissions
Macrophage Inflammatory Proteins
Pulmonary diseases
rosmarinic acid
Chemokine CCL2
88 Citations (Scopus)

Rosmarinic acid inhibits lung injury induced by diesel exhaust particles.

C., S., H., T., N, O., N., S., M., N., R., Y., K, I., Y., K., T., O. T. Y. & Osakabe, N., 2003 Apr 1, In : Free Radic. Biol. Med.. 34, p. 1060-1069

Research output: Contribution to journalArticle

181 Citations (Scopus)

Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: Differences between human and rat

Natsume, M., Osakabe, N., Oyama, M., Sasaki, M., Baba, S., Nakamura, Y., Osawa, T. & Terao, J., 2003 Apr 1, In : Free Radical Biology and Medicine. 34, 7, p. 840-849 10 p.

Research output: Contribution to journalArticle

Catechin
Rats
Plasmas
Metabolites
Glucuronides
181 Citations (Scopus)

Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: differences between human and rat.

M, N., N, O., M., O., M., S., S., B., Y., N., T., O., J., T. & Osakabe, N., 2003 Apr 1, In : Free Radic. Biol. Med.. 34, p. 840-849

Research output: Contribution to journalArticle