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Research Output 1998 2019

  • 6790 Citations
  • 49 h-Index
  • 130 Article
  • 1 Chapter
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Article

(-)-Epicatechin metabolites modulate in gene expression of oxidazed LDL stimulated human umbilical vein endothelial cells (HUVEC)

Osakabe, N., Fukasawa, T., Yasuda1, A., Matsumoto, I., Abe, K. & Osawa, T., 2003 Dec 5, In : Default journal.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans

Baba, S., Osakabe, N., Natsume, M., Yasuda, A., Muto, Y., Hiyoshi, K., Takano, H., Yoshikawa, T. & Terao, J., 2005 Jan, In : European Journal of Nutrition. 44, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Perilla frutescens
rosmarinic acid
excretion
Perilla
metabolism

Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans.

S., B., N, O., M., N., A., Y., Y., M., K., H., H., T., T., Y., J., T. & Osakabe, N., 2005 Feb 1, In : Europian Jounal of Nutrition. 44, p. 1-9

Research output: Contribution to journalArticle

90 Citations (Scopus)

Absorption and urinary excretion of (-)-epicatechin after administration of different levels of cocoa powder or (-)-epicatechin in rats

Baba, S., Osakabe, N., Natsume, M., Muto, Y., Takizawa, T. & Terao, J., 2001, In : Journal of Agricultural and Food Chemistry. 49, 12, p. 6050-6056 7 p.

Research output: Contribution to journalArticle

Cocoa
cocoa powder
Catechin
epicatechin
Powders

Absorption and Urinary Excretion of (-)-Epicatechin after Administration of Different Levels of Cocoa Powder or (-)-Epicatechin in Rats.

S., B., N, O., M, N., Y., M., T., T., J., T. & Osakabe, N., 2000 Dec 1, In : J. Agric. Food Chem.. 49, p. 6050-6056

Research output: Contribution to journalArticle

189 Citations (Scopus)

Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats.

S., B., N, O., M., N., J., T. & Osakabe, N., 2002 Jul 1, In : Free Radic. Biol. Med.. 33, p. 142-148

Research output: Contribution to journalArticle

189 Citations (Scopus)

Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

Baba, S., Osakabe, N., Natsume, M. & Terao, J., 2002 Jul 1, In : Free Radical Biology and Medicine. 33, 1, p. 142-148 7 p.

Research output: Contribution to journalArticle

Catechin
Rats
Plasmas
Lipid Peroxides
Copper

A Cacao polyphenols on cardiovascular disease prevention

Osakabe, N., 2006 Nov 12, In : Kadota Fund International Forum 2006.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Acylated anthocyanins derived from purple carrot (: Daucus carota L.) induce elevation of blood flow in rat cremaster arteriole

Tsutsumi, A., Horikoshi, Y., Fushimi, T., Saito, A., Koizumi, R., Fujii, Y., Hu, Q. Q., Hirota, Y., Aizawa, K. & Osakabe, N., 2019 Mar 1, In : Food and Function. 10, 3, p. 1726-1735 10 p.

Research output: Contribution to journalArticle

Daucus carota
carrots
blood flow
cyanidin
glycosides
8 Citations (Scopus)

Alteration of the systemic and microcirculation by a single oral dose of flavan-3-ols

Ingawa, K., Aruga, N., Matsumura, Y., Shibata, M. & Osakabe, N., 2014 Apr 16, In : PLoS One. 9, 4, e94853.

Research output: Contribution to journalArticle

Microcirculation
Blood pressure
flavanols
Muscle
mouth

Analyses of Polyphenol Constituents in Defatted Cacao Liquor and Antioxidative Effects on Human LDL in vitro

Natsume, M., Osakabe, N., Takizawa, T., Nakamura, T., Miyake, H., Ito, H., Hatano, T. & Yoshida, T., 1999 Dec 5, In : Default journal.

Research output: Contribution to journalArticle

173 Citations (Scopus)

Analyses of Polyphenols in Cacao Liquor, Cocoa, and Chocolate by Normal-Phase and Reversed-Phase HPLC

Natsume, M., Osakabe, N., Yamagishi, M., Takizawa, T., Nakamura, T., Miyatake, H., Hatano, T. & Yoshida, T., 2000 Dec, In : Bioscience, Biotechnology and Biochemistry. 64, 12, p. 2581-2587 7 p.

Research output: Contribution to journalArticle

chocolate liquor
Cocoa
cocoa (beverage)
Catechin
Polyphenols
173 Citations (Scopus)

Analyses of polyphenols in cacao liquor, cocoa, and chocolate by normal- phase and reversed-phase HPLC.

M, N., N, O., M., Y., T., T., T., N., H., M., T., H., T., Y. & Osakabe, N., 2000 Dec 1, In : Biosci. Biotechnol. Biochem.. 33, p. 2581-2587

Research output: Contribution to journalArticle

2 Citations (Scopus)

Analysis of polyphenol constituents in cocoa and chocolate

Natsume, M., Osakabe, N., Takizawa, T., Nakamura, T., Miyatake, H., Hatano, T. & Yoshida, T., 2002, In : ACS Symposium Series. 803, p. 180-213 34 p.

Research output: Contribution to journalArticle

Cocoa
Catechin
Polyphenols
Antioxidants
Oligomers

Analysis of polyphenol constituents in cocoa and chocolate.

M., N., N, O., T., T., T., N., H., M., T., H., T., Y. & Osakabe, N., 2001 Jan 1, In : ACS Symposium Series. 754, p. 180-198

Research output: Contribution to journalArticle

28 Citations (Scopus)

Anticlastogenic activity of cacao: Inhibitory effect of cacao liquor polyphenols against mitomycin C-induced DNA damage

Yamagishi, M., Osakabe, N., Natsume, M., Adachi, T., Takizawa, T., Kumon, H. & Osawa, T., 2001, In : Food and Chemical Toxicology. 39, 12, p. 1279-1283 5 p.

Research output: Contribution to journalArticle

chocolate liquor
mitomycin
antimutagenic activity
Polyphenols
Mitomycin
28 Citations (Scopus)

Anticlastogenic activity of cacao: inhibitory effect of cacao liquor polyphenols against mitomycin C-induced DNA damage.

M., Y., N, O., M., N., T., A., T., T., H., K., T., O. & Osakabe, N., 2001 Dec 1, In : Food Chem. Toxicol.. 39, p. 1279-1283

Research output: Contribution to journalArticle

93 Citations (Scopus)

Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); Inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism

Osakabe, N., Takano, H., Sanbongi, C., Yasuda, A., Yanagisawa, R., Inoue, K. I. & Yoshikawa, T., 2004, In : BioFactors. 21, 1-4, p. 127-131 5 p.

Research output: Contribution to journalArticle

Anti-Allergic Agents
Anti-Inflammatory Agents
Acetates
Infiltration
rosmarinic acid
93 Citations (Scopus)

Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism.

N, O., H., O. NT., C., S., A., Y., R., Y., K., I., T., Y. & Osakabe, N., 2004 Sep 1, In : Biofactors.. 21, p. 127-131

Research output: Contribution to journalArticle

35 Citations (Scopus)

Antimutagenic activity of cacao: Inhibitory effect of cacao liquor polyphenols on the mutagenic action of heterocyclic amines

Yamagishi, M., Natsume, M., Nagaki, A., Adachi, T., Osakabe, N., Takizawa, T., Kumon, H. & Osawa, T., 2000, In : Journal of Agricultural and Food Chemistry. 48, 10, p. 5074-5078 5 p.

Research output: Contribution to journalArticle

chocolate liquor
heterocyclic amines
antimutagenic activity
Polyphenols
Amines
35 Citations (Scopus)

Antimutagenic activity of cacao: inhibitory effect of cacao liquor polyphenols on the mutagenic action of heterocyclic amines.

M., Y., M., N., A., N., T., A., N, O., T., T., H., K., T., O. & Osakabe, N., 2000 Oct 1, In : J..Agric. Food Chem.. 48, p. 5074-5078

Research output: Contribution to journalArticle

28 Citations (Scopus)

Antioxidant effects of polyphenols in chocolate on low-density lipoprotein both in vitro and ex vivo

Hirano, R., Osakabe, N., Iwamoto, T., Matsumoto, A., Natsume, M., Takizawa, T., Igarashi, O., Itakura, H. & Kondo, K., 2000, In : Journal of Nutritional Science and Vitaminology. 46, 4, p. 199-204 6 p.

Research output: Contribution to journalArticle

chocolate
low density lipoprotein
chocolate liquor
polyphenols
antioxidants
28 Citations (Scopus)

Antioxidant effects of polyphenols in chocolate on low-density lipoprotein both in vitro and ex vivo.

R., H., N, O., A, I., A, M., M., N., T., T., O., I., K., K., H., I. & Osakabe, N., 2000 Aug 1, In : J. Nutr. Sci. Vitaminol.. 46, p. 199-204

Research output: Contribution to journalArticle

8 Citations (Scopus)

Antioxidative polyphenolic substances in cacao liquor

Osakabe, N., Yamagishi, M., Natsume, M., Takizawa, T., Nakamura, T. & Osawa, T., 2000, In : ACS Symposium Series. 754, p. 88-101 14 p.

Research output: Contribution to journalArticle

Cocoa
Glycosides
Oxidative stress
Catechin
Vitamins

Antioxidative polyphenols in Theobroma cacao

N, O., N., O., M., N., A., Y., T., T., T., H., T., Y., T., O., K., K. & Osakabe, N., 2001 Apr 1, In : Default journal.

Research output: Contribution to journalArticle

193 Citations (Scopus)

Antioxidative Polyphenols Isolated from Theobroma cacao

Sanbongi, C., Osakabe, N., Natsume, M., Takizawa, T., Gomi, S. & Osawa, T., 1998 Feb, In : Journal of Agricultural and Food Chemistry. 46, 2, p. 454-457 4 p.

Research output: Contribution to journalArticle

Theobroma cacao
Quercetin
Glucosides
chocolate
Polyphenols
193 Citations (Scopus)

Antioxidative Polyphenols Isolated from Theobroma cacao.

C., S., N, O., M., N., T., T., S., G., T., O. & Osakabe, N., 1998 Feb 1, In : J. Agric .Food Chem.. 46, p. 454-457

Research output: Contribution to journalArticle

18 Citations (Scopus)

A single oral administration of theaflavins increases energy expenditure and the expression of metabolic genes

Kudo, N., Arai, Y., Suhara, Y., Ishii, T., Nakayama, T. & Osakabe, N., 2015 Sep 16, In : PLoS One. 10, 9, e0137809.

Research output: Contribution to journalArticle

theaflavins
energy expenditure
oral administration
Genes
genes
15 Citations (Scopus)

A single oral dose of flavan-3-ols enhances energy expenditure by sympathetic nerve stimulation in mice

Kamio, N., Suzuki, T., Watanabe, Y., Suhara, Y. & Osakabe, N., 2016 Feb 1, In : Free Radical Biology and Medicine. 91, p. 256-263 8 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Butoxamine
Muscle
Messenger RNA
Proteins
198 Citations (Scopus)

Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers

Baba, S., Osakabe, N., Yasuda, A., Natsume, M., Takizawa, T., Nakamura, T. & Terao, J., 2000, In : Free Radical Research. 33, 5, p. 635-641 7 p.

Research output: Contribution to journalArticle

Cocoa
Catechin
Metabolites
Plasmas
Glucuronides
198 Citations (Scopus)

Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers.

S., B., N, O., A, Y., M., N., T., T., T., N., J., T. & Osakabe, N., 2000 Nov 1, In : Free Radic. Res.. 33, p. 635-641

Research output: Contribution to journalArticle

20 Citations (Scopus)

Cacao liquor polyphenols reduce oxidative stress without maintaining alpha-tocopherol levels in rats fed a vitamin E-deficient diet.

N, O., M., Y., T., T., T., O. & Osakabe, N., 2001 Jan 1, In : Lipids.. 36, p. 67-71

Research output: Contribution to journalArticle

20 Citations (Scopus)

Cacao liquor polyphenols reduce oxidative stress without maintaining α-tocopherol levels in rats fed a vitamin E-deficient diet

Yamagishi, M., Osakabe, N., Takizawa, T. & Osawa, T., 2001, In : Lipids. 36, 1, p. 67-71 5 p.

Research output: Contribution to journalArticle

chocolate liquor
Oxidative stress
Tocopherols
Polyphenols
Nutrition
7 Citations (Scopus)

Cacao liquor proanthocyanidins inhibit lung injury induced by diesel exhaust particles

Yasuda, A., Takano, H., Osakabe, N., Sanbongi, C., Fukuda, K., Natsume, M., Yanagisawa, R., Inoue, K., Kato, Y., Osawa, T. & Yoshikawa, T., 2008 Apr, In : International Journal of Immunopathology and Pharmacology. 21, 2, p. 279-288 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Cacao liquor proanthocyanidins inhibit lung injury induced by diesel exhaust particles.

Yasuda, A., Yoshikawa, A. Y. H. N. C. & Osakabe, N., 2008 Jul 1, In : International Jounal of Immunopathological Pharmacolgy. 21, p. 279-288

Research output: Contribution to journalArticle

12 Citations (Scopus)

Cacao polyphenol extract suppresses transformation of an aryl hydrocarbon receptor in C57BL/6 mice

Mukai, R., Fukuda, I., Nishiumi, S., Natsume, M., Osakabe, N., Yoshida, K. I. & Ashida, H., 2008 Nov 12, In : Journal of Agricultural and Food Chemistry. 56, 21, p. 10399-10405 7 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Polyphenols
hydrocarbons
polyphenols
Methylcholanthrene
12 Citations (Scopus)

Cacao polyphenol extract suppresses transformation of an aryl hydrocarbon receptor in C57BL/6 mice.

Mukai, R., Ashida, R. M. I. S. M. N. & Osakabe, N., 2008 Nov 1, In : Jounal of Agricalural Food Chemistry. 56, p. 10399-10405

Research output: Contribution to journalArticle

3 Citations (Scopus)

Cacao polyphenols and atherosclerosis

Osakabe, N., 2005, In : Journal of Clinical Biochemistry and Nutrition. 37, 3, p. 67-72 6 p.

Research output: Contribution to journalArticle

Catechin
Cocoa
Polyphenols
atherosclerosis
polyphenols
32 Citations (Scopus)

Cacao polyphenols influence the regulation of apolipoprotein in hepg2 and caco2 cells

Yasuda, A., Natsume, M., Osakabe, N., Kawahata, K. & Koga, J., 2011 Feb 23, In : Journal of Agricultural and Food Chemistry. 59, 4, p. 1470-1476 7 p.

Research output: Contribution to journalArticle

apolipoproteins
Apolipoproteins
Polyphenols
Cocoa
polyphenols
58 Citations (Scopus)

Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and low-density lipoprotein from oxidation in vitro.

N, O., A., Y., M., N., Takizawa, T., T, T., J., T., K., K. & Osakabe, N., 2002 Jan 1, In : Exp. Biol. Med.. 227, p. 51-56

Research output: Contribution to journalArticle

58 Citations (Scopus)

Catechins and their oligomers linked by C4 → C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro

Osakabe, N., Yasuda, A., Natsume, M., Takizawa, T., Terao, J. & Kondo, K., 2002 Jan, In : Experimental Biology and Medicine. 227, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

Catechin
Polyphenols
LDL Lipoproteins
Oligomers
Oxidation
9 Citations (Scopus)

Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice

Ushiama, S., Ishimaru, Y., Narukawa, M., Yoshioka, M., Kozuka, C., Watanabe, N., Tsunoda, M., Osakabe, N., Asakura, T., Masuzaki, H. & Abe, K., 2016 Jan 25, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Catecholamines
Brain
Transcription Factors
Brushes
Medical problems
44 Citations (Scopus)

Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model

Yamagishi, M., Natsume, M., Osakabe, N., Okazaki, K., Furukawa, F., Imazawa, T., Nishikawa, A. & Hirose, M., 2003 Feb 28, In : Cancer Letters. 191, 1, p. 49-57 9 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.

Yamagishi, Y., M., M., M., N., N, O., K, O., F, F., T., I., A, N., M., H. & Osakabe, N., 2003 Feb 1, In : Cancer Lett.. 191, p. 49-57

Research output: Contribution to journalArticle

70 Citations (Scopus)

Cocoa powder enhances the level of antioxidative activity in rat plasma

Baba, S., Osakabe, N., Natsume, M., Yasuda, A., Takizawa, T., Nakamura, T. & Terao, J., 2000, In : British Journal of Nutrition. 84, 5, p. 673-680 8 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Cocoa powder enhances the level of antioxidative activity in rat plasma.

S, B., N, O., M., N., A., Y., T, T., T., N., J., T. & Osakabe, N., 2000 Jan 1, In : Br. J. Nutr.. 84, p. 673-680

Research output: Contribution to journalArticle

3 Citations (Scopus)

Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice

Nakagawa, Y., Ishimura, K., Oya, S., Kamino, M., Fujii, Y., Nanba, F., Toda, T., Ishii, T., Adachi, T., Suhara, Y. & Osakabe, N., 2018 Jul 1, In : PLoS One. 13, 7, e0201203.

Research output: Contribution to journalArticle

Proanthocyanidins
procyanidins
brown adipose tissue
catecholamines
Catecholamines