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Research Output 1998 2019

  • 6790 Citations
  • 49 h-Index
  • 130 Article
  • 1 Chapter
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Article
2007
29 Citations (Scopus)

Pulmonary exposure to diesel exhaust particles enhances fatty change of the liver in obese diabetic mice

Tomaru, M., Takano, H., Inoue, K. I., Yanagisawa, R., Osakabe, N., Yasuda, A., Shimada, A., Kato, Y. & Uematsu, H., 2007 Jan, In : International Journal of Molecular Medicine. 19, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

Recent Topics of Cacao Polyphenols on Metabolic Syndrome

Osakabe, N., 2007 Sep 14, In : Bio Korea 2007.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Short-term supplementation with plant extracts rich in flavonoids protect nigrostriatal dopaminergic neurons in a rat model of Parkinson's disease

Datla, K. P., Zbarsky, V., Rai, D., Parkar, S., Osakabe, N., Aruoma, O. I. & Dexter, D. T., 2007 Aug, In : Journal of the American College of Nutrition. 26, 4, p. 341-349 9 p.

Research output: Contribution to journalArticle

Parkinson disease
flavanols
homovanillic acid
plant extracts
tangerines
2006

A Cacao polyphenols on cardiovascular disease prevention

Osakabe, N., 2006 Nov 12, In : Kadota Fund International Forum 2006.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Determination of rosmarinic acid and luteolin in Perilla frutescens Britton (Labiatae)

Natsume, M., Muto, Y., Fukuda, K., Tokunaga, T. & Osakabe, N., 2006 Apr 30, In : Journal of the Science of Food and Agriculture. 86, 6, p. 897-901 5 p.

Research output: Contribution to journalArticle

Perilla frutescens
Luteolin
rosmarinic acid
luteolin
Lamiaceae
2005
79 Citations (Scopus)

Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans

Baba, S., Osakabe, N., Natsume, M., Yasuda, A., Muto, Y., Hiyoshi, K., Takano, H., Yoshikawa, T. & Terao, J., 2005 Jan, In : European Journal of Nutrition. 44, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Perilla frutescens
rosmarinic acid
excretion
Perilla
metabolism

Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans.

S., B., N, O., M., N., A., Y., Y., M., K., H., H., T., T., Y., J., T. & Osakabe, N., 2005 Feb 1, In : Europian Jounal of Nutrition. 44, p. 1-9

Research output: Contribution to journalArticle

3 Citations (Scopus)

Cacao polyphenols and atherosclerosis

Osakabe, N., 2005, In : Journal of Clinical Biochemistry and Nutrition. 37, 3, p. 67-72 6 p.

Research output: Contribution to journalArticle

Catechin
Cocoa
Polyphenols
atherosclerosis
polyphenols

Physiological activity of cacao polyphenols

N, O., N., O., S., B., M., Y., T., T., T., T. J. O. & Osakabe, N., 2005 Dec 15, In : Default journal.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Suppressive effect of cocoa powder on atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits.

Kurosawa, T., Itoh, F., Nozaki, A., Nakano, Y., Katsuda, S. I., Osakabe, N., Tsubone, H., Kondo, K. & Itakura, H., 2005, In : Journal of Atherosclerosis and Thrombosis. 12, 1, p. 20-28 9 p.

Research output: Contribution to journalArticle

Cocoa
Powders
Polyphenols
Lipids
Thiobarbituric Acid Reactive Substances
68 Citations (Scopus)

Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits

Kurosawa, T., Itoh, F., Nozaki, A., Nakano, Y., Katsuda, S. I., Osakabe, N., Tsubone, H., Kondo, K. & Itakura, H., 2005 Apr, In : Atherosclerosis. 179, 2, p. 237-246 10 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits.

Kurosawa, K., T., T., N, O., F., I., A., N., Y., N., S, K., H., T., K., K., H., I. & Osakabe, N., 2005 Apr 1, In : Atherosclerosis. 179, p. 237-246

Research output: Contribution to journalArticle

2004
93 Citations (Scopus)

Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); Inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism

Osakabe, N., Takano, H., Sanbongi, C., Yasuda, A., Yanagisawa, R., Inoue, K. I. & Yoshikawa, T., 2004, In : BioFactors. 21, 1-4, p. 127-131 5 p.

Research output: Contribution to journalArticle

Anti-Allergic Agents
Anti-Inflammatory Agents
Acetates
Infiltration
rosmarinic acid
93 Citations (Scopus)

Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism.

N, O., H., O. NT., C., S., A., Y., R., Y., K., I., T., Y. & Osakabe, N., 2004 Sep 1, In : Biofactors.. 21, p. 127-131

Research output: Contribution to journalArticle

17 Citations (Scopus)

Dose-response study of daily cocoa intake on the oxidative susceptibility of low-density lipoprotein in healthy human volunteers

Osakabe, N., Baba, S., Yasuda, A., Iwamoto, T., Kamiyama, M., Tokunaga, T. & Kondo, K., 2004 Dec, In : Journal of Health Science. 50, 6, p. 679-684 6 p.

Research output: Contribution to journalArticle

Cocoa
LDL Lipoproteins
Powders
Polyphenols
Sugars
17 Citations (Scopus)

Dose-Response Study of Daily Cocoa Intake on the Oxidative Susceptibility of Low-Density Lipoprotein in Healthy Human Volunteers.

N, O., S., B., T., I., A., Y., M., K., K., K. & Osakabe, N., 2004 Sep 1, In : J. Health Sci.. 50, p. 679-684

Research output: Contribution to journalArticle

101 Citations (Scopus)

Extract of Perilla frutescens Enriched for Rosmarinic Acid, a Polyphenolic Phytochemical, Inhibits Seasonal Allergic Rhinoconjunctivitis in Humans

Takano, H., Osakabe, N., Sanbongi, C., Yanagisawa, R., Inoue, K. I., Yasuda, A., Natsume, M., Baba, S., Ichiishi, E. I. & Yoshikawa, T., 2004 Mar, In : Experimental Biology and Medicine. 229, 3, p. 247-254 8 p.

Research output: Contribution to journalArticle

Phytochemicals
Blood
Fluids
Interleukin-8
Interleukin-1
101 Citations (Scopus)

Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans.

H., T., N, O., C., S., A., Y., R., Y., K., I., M., N., E., I., T., Y. & Osakabe, N., 2004 Mar 1, In : Exp. Biol. Med.. 229, p. 247-254

Research output: Contribution to journalArticle

46 Citations (Scopus)

Ingestion of Proanthocyanidins Derived from Cacao Inhibits Diabetes-Induced Cataract Formation in Rats

Osakabe, N., Yamagishi, M., Natsume, M., Yasuda, A. & Osawa, T., 2004 Jan, In : Experimental Biology and Medicine. 229, 1, p. 33-39 7 p.

Research output: Contribution to journalArticle

Proanthocyanidins
Streptozocin
Medical problems
Nutrition
Rats
46 Citations (Scopus)

Ingestion of proanthocyanidins derived from cacao inhibits diabetes-induced cataract formation in rats.

N, O., M., Y., M, N., A, Y., T., O. & Osakabe, N., 2004 Jan 1, In : Exp. Biol. Med.. 229, p. 33-39

Research output: Contribution to journalArticle

50 Citations (Scopus)

In vitro antioxidative activity of ( - )-epicatechin glucuronide metabolites present in human and rat plasma

Natsume, M., Osakabe, N., Yasuda, A., Baba, S., Tokunaga, T., Kondo, K., Osawa, T. & Terao, J., 2004 Dec, In : Free Radical Research. 38, 12, p. 1341-1348 8 p.

Research output: Contribution to journalArticle

Catechin
Metabolites
Rats
Glucuronides
Plasmas
50 Citations (Scopus)

In vitro antioxidative activity of (-)-epicatechin glucuronide metabolites present in human and rat plasma.

M., N., N, O., A., Y., S., B., T., T., K., K., T., O., J., T. & Osakabe, N., 2004 Dec 1, In : Free Radic. Res.. 38, p. 1341-1348

Research output: Contribution to journalArticle

92 Citations (Scopus)
ferulic acid
Plasmas
Coumaric Acids
caffeic acid
rosmarinic acid
165 Citations (Scopus)

Rosmarinic acid inhibits epidermal inflammatory responses: Anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model

Osakabe, N., Yasuda, A., Natsume, M. & Yoshikawa, T., 2004 Apr, In : Carcinogenesis. 25, 4, p. 549-557 9 p.

Research output: Contribution to journalArticle

165 Citations (Scopus)

Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model.

N, O., A., Y., M., N., T., Y. & Osakabe, N., 2004 Apr 1, In : Carcinogenesis. 25, p. 549-557

Research output: Contribution to journalArticle

99 Citations (Scopus)

Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model

Sanbongi, C., Takano, H., Osakabe, N., Sasa, N., Natsume, M., Yanagisawa, R., Inoue, K. I., Sadakane, K., Ichinose, T. & Yoshikawa, T., 2004, In : Clinical and Experimental Allergy. 34, 6, p. 971-977 7 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model.

C., S., H., T., N, O., N., S., M., N., R., Y., K., I., K., S., T., I., T., Y. & Osakabe, N., 2004 Jun 1, In : Clin. Exp. Allergy. 34, p. 971-977

Research output: Contribution to journalArticle

2003

(-)-Epicatechin metabolites modulate in gene expression of oxidazed LDL stimulated human umbilical vein endothelial cells (HUVEC)

Osakabe, N., Fukasawa, T., Yasuda1, A., Matsumoto, I., Abe, K. & Osawa, T., 2003 Dec 5, In : Default journal.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model

Yamagishi, M., Natsume, M., Osakabe, N., Okazaki, K., Furukawa, F., Imazawa, T., Nishikawa, A. & Hirose, M., 2003 Feb 28, In : Cancer Letters. 191, 1, p. 49-57 9 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.

Yamagishi, Y., M., M., M., N., N, O., K, O., F, F., T., I., A, N., M., H. & Osakabe, N., 2003 Feb 1, In : Cancer Lett.. 191, p. 49-57

Research output: Contribution to journalArticle

Physiological activities of polyphenols in Theobroma cacao~Cacao polyphenols prevent atherosclerosis~

Osakabe, N., Natsume, M., Baba, S., Yasuda, A., Yamagishi, M., Terao, J. & Osawa, T., 2003 Nov 15, In : 1st International Conference on Polyphenols and Health(ICPH).

Research output: Contribution to journalArticle

88 Citations (Scopus)

Rosmarinic acid inhibits lung injury induced by diesel exhaust particles

Sanbongi, C., Takano, H., Osakabe, N., Sasa, N., Natsume, M., Yanagisawa, R., Inoue, K. I., Kato, Y., Osawa, T. & Yoshikawa, T., 2003 Apr 15, In : Free Radical Biology and Medicine. 34, 8, p. 1060-1069 10 p.

Research output: Contribution to journalArticle

Vehicle Emissions
Macrophage Inflammatory Proteins
Pulmonary diseases
rosmarinic acid
Chemokine CCL2
88 Citations (Scopus)

Rosmarinic acid inhibits lung injury induced by diesel exhaust particles.

C., S., H., T., N, O., N., S., M., N., R., Y., K, I., Y., K., T., O. T. Y. & Osakabe, N., 2003 Apr 1, In : Free Radic. Biol. Med.. 34, p. 1060-1069

Research output: Contribution to journalArticle

181 Citations (Scopus)

Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: Differences between human and rat

Natsume, M., Osakabe, N., Oyama, M., Sasaki, M., Baba, S., Nakamura, Y., Osawa, T. & Terao, J., 2003 Apr 1, In : Free Radical Biology and Medicine. 34, 7, p. 840-849 10 p.

Research output: Contribution to journalArticle

Catechin
Rats
Plasmas
Metabolites
Glucuronides
181 Citations (Scopus)

Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: differences between human and rat.

M, N., N, O., M., O., M., S., S., B., Y., N., T., O., J., T. & Osakabe, N., 2003 Apr 1, In : Free Radic. Biol. Med.. 34, p. 840-849

Research output: Contribution to journalArticle

2002
189 Citations (Scopus)

Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats.

S., B., N, O., M., N., J., T. & Osakabe, N., 2002 Jul 1, In : Free Radic. Biol. Med.. 33, p. 142-148

Research output: Contribution to journalArticle

189 Citations (Scopus)

Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

Baba, S., Osakabe, N., Natsume, M. & Terao, J., 2002 Jul 1, In : Free Radical Biology and Medicine. 33, 1, p. 142-148 7 p.

Research output: Contribution to journalArticle

Catechin
Rats
Plasmas
Lipid Peroxides
Copper
2 Citations (Scopus)

Analysis of polyphenol constituents in cocoa and chocolate

Natsume, M., Osakabe, N., Takizawa, T., Nakamura, T., Miyatake, H., Hatano, T. & Yoshida, T., 2002, In : ACS Symposium Series. 803, p. 180-213 34 p.

Research output: Contribution to journalArticle

Cocoa
Catechin
Polyphenols
Antioxidants
Oligomers
58 Citations (Scopus)

Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and low-density lipoprotein from oxidation in vitro.

N, O., A., Y., M., N., Takizawa, T., T, T., J., T., K., K. & Osakabe, N., 2002 Jan 1, In : Exp. Biol. Med.. 227, p. 51-56

Research output: Contribution to journalArticle

58 Citations (Scopus)

Catechins and their oligomers linked by C4 → C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro

Osakabe, N., Yasuda, A., Natsume, M., Takizawa, T., Terao, J. & Kondo, K., 2002 Jan, In : Experimental Biology and Medicine. 227, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

Catechin
Polyphenols
LDL Lipoproteins
Oligomers
Oxidation
46 Citations (Scopus)

Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats

Yamagishi, M., Natsume, M., Osakabe, N., Nakamura, H., Furukawa, F., Imazawa, T., Nishikawa, A. & Hirose, M., 2002 Nov 28, In : Cancer Letters. 185, 2, p. 123-130 8 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects

Hatano, T., Miyatake, H., Natsume, M., Osakabe, N., Takizawa, T., Ito, H. & Yoshida, T., 2002 Apr 8, In : Phytochemistry. 59, 7, p. 749-758 10 p.

Research output: Contribution to journalArticle

chocolate liquor
Polyphenols
Glycosides
proanthocyanidins
glycosides
149 Citations (Scopus)

Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects.

T., H., H., M., M., N., N, O., T, T., H., I., T., Y. & Osakabe, N., 2002 Apr 1, In : Phytochemistry. 59, p. 749-758

Research output: Contribution to journalArticle

137 Citations (Scopus)

Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-GalN)-sensitized mice

Osakabe, N., Yasuda, A., Natsume, M., Sanbongi, C., Kato, Y., Osawa, T. & Yoshikawa, T., 2002 Sep 15, In : Free Radical Biology and Medicine. 33, 6, p. 798-806 9 p.

Research output: Contribution to journalArticle

Galactosamine
Liver
Lipopolysaccharides
Tumor Necrosis Factor-alpha
Plasmas
137 Citations (Scopus)
2001
90 Citations (Scopus)

Absorption and urinary excretion of (-)-epicatechin after administration of different levels of cocoa powder or (-)-epicatechin in rats

Baba, S., Osakabe, N., Natsume, M., Muto, Y., Takizawa, T. & Terao, J., 2001, In : Journal of Agricultural and Food Chemistry. 49, 12, p. 6050-6056 7 p.

Research output: Contribution to journalArticle

Cocoa
cocoa powder
Catechin
epicatechin
Powders

Analysis of polyphenol constituents in cocoa and chocolate.

M., N., N, O., T., T., T., N., H., M., T., H., T., Y. & Osakabe, N., 2001 Jan 1, In : ACS Symposium Series. 754, p. 180-198

Research output: Contribution to journalArticle