• 6885 Citations
  • 49 h-Index
19982019

Research output per year

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Research Output

  • 6885 Citations
  • 49 h-Index
  • 128 Article
  • 2 Review article
  • 1 Chapter
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Article
196 Citations (Scopus)
Open Access

Daily cocoa intake reduces the susceptibility of low-density lipoprotein to oxidation as demonstrated in healthy human volunteers

Osakabe, N., Baba, S., Yasuda, A., Iwamoto, T., Kamiyama, M., Takizawa, T., Itakura, H. & Kondo, K., 2001 Jan 1, In : Free Radical Research. 34, 1, p. 93-99 7 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Daily cocoa intake reduces the susceptibility of low-density lipoprotein to oxidation as demonstrated in healthy human volunteers.

N, O., S., B., A., Y., T., I., M., K., T., T., K., K., H., I. & Osakabe, N., 2001 Jan 1, In : Free Radic. Res.. 34, p. 93-99

Research output: Contribution to journalArticle

109 Citations (Scopus)

Determination of rosmarinic acid and luteolin in Perilla frutescens Britton (Labiatae)

Natsume, M., Muto, Y., Fukuda, K., Tokunaga, T. & Osakabe, N., 2006 Apr 30, In : Journal of the Science of Food and Agriculture. 86, 6, p. 897-901 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice

Tomaru, M., Takano, H., Osakabe, N., Yasuda, A., Inoue, K. I., Yanagisawa, R., Ohwatari, T. & Uematsu, H., 2007 Apr 1, In : Nutrition. 23, 4, p. 351-355 5 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Dose-response study of daily cocoa intake on the oxidative susceptibility of low-density lipoprotein in healthy human volunteers

Osakabe, N., Baba, S., Yasuda, A., Iwamoto, T., Kamiyama, M., Tokunaga, T. & Kondo, K., 2004 Dec 1, In : Journal of Health Science. 50, 6, p. 679-684 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Dose-Response Study of Daily Cocoa Intake on the Oxidative Susceptibility of Low-Density Lipoprotein in Healthy Human Volunteers.

N, O., S., B., T., I., A., Y., M., K., K., K. & Osakabe, N., 2004 Sep 1, In : J. Health Sci.. 50, p. 679-684

Research output: Contribution to journalArticle

19 Citations (Scopus)

Effects of cacao liquor polyphenols on cardiovascular and autonomic nervous functions in hypercholesterolaemic rabbits

Akita, M., Kuwahara, M., Itoh, F., Nakano, Y., Osakabe, N., Kurosawa, T. & Tsubone, H., 2008 Dec 1, In : Basic and Clinical Pharmacology and Toxicology. 103, 6, p. 581-587 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Effects of cacao liquor polyphenols on cardiovascular and autonomic nervous functions in hypercholesterolaemic rabbits.

Akita, M., Tsubone, M. AM. F. Y. N. & Osakabe, N., 2008 Dec 1, In : Basic Clinical Pharmacology and Toxicology.. 103, p. 581-587

Research output: Contribution to journalArticle

11 Citations (Scopus)

Effects of cacao liquor polyphenols on the susceptibility of low-density lipoprotein to oxidation in hypercholesterolemic rabbits.

Osakabe, N., Natsume, M., Adachi, T., Yamagishi, M., Hirano, R., Takizawa, T., Itakura, H. & Kondo, K., 2000, In : Journal of atherosclerosis and thrombosis. 7, 3, p. 164-168 5 p.

Research output: Contribution to journalArticle

Open Access
33 Citations (Scopus)

Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats

Yamagishi, M., Natsume, M., Osakabe, N., Nakamura, H., Furukawa, F., Imazawa, T., Nishikawa, A. & Hirose, M., 2002 Nov 28, In : Cancer Letters. 185, 2, p. 123-130 8 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Effects of polyphenol substances derived from theobroma cacao on gastric mucosal lesion induced by ethanol

Osakabe, N., Sanbongi, C., Yamagishi, M., Takizawa, T. & Osawa, T., 1998 Jan 1, In : Bioscience, Biotechnology and Biochemistry. 62, 8, p. 1535-1538 4 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Effects of polyphenol substances derived from Theobroma cacao on gastric mucosal lesion induced by ethanol.

N, O., Sanbongi, S., C., C., M., Y., T., T., T., O. & Osakabe, N., 1998 Aug 1, In : Biosci. Biotechnol. Biochem.. 62, p. 1535-1538

Research output: Contribution to journalArticle

52 Citations (Scopus)

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice

Hirota, Y., Nakagawa, K., Isomoto, K., Sakaki, T., Kubodera, N., Kamao, M., Osakabe, N., Suhara, Y. & Okano, T., 2018 Oct 1, In : PLoS One. 13, 10, e0199856.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Electrochemical determination with a long-length carbon nanotube electrode of quercetin glucosides in onion, apple peel, and tartary buckwheat

Takahashi, S., Muguruma, H., Osakabe, N., Inoue, H. & Ohsawa, T., 2019 Dec 1, In : Food Chemistry. 300, 125189.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Elucidation of the interaction between flavan-3-ols and bovine serum albumin and its effect on their in-vitro cytotoxicity

Fujii, Y., Suhara, Y., Sukikara, Y., Teshima, T., Hirota, Y., Yoshimura, K. & Osakabe, N., 2019 Oct 11, In : Molecules. 24, 20, 3667.

Research output: Contribution to journalArticle

Open Access

Enhancement of energy expenditure following a single oral dose of flavan-3-ols associated with an increase in catecholamine secretion

Matsumura, Y., Nakagawa, Y., Mikome, K., Yamamoto, H. & Osakabe, N., 2014 Nov 6, In : PLoS ONE. 9, 11, e112180.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Extract of Perilla frutescens Enriched for Rosmarinic Acid, a Polyphenolic Phytochemical, Inhibits Seasonal Allergic Rhinoconjunctivitis in Humans

Takano, H., Osakabe, N., Sanbongi, C., Yanagisawa, R., Inoue, K. I., Yasuda, A., Natsume, M., Baba, S., Ichiishi, E. I. & Yoshikawa, T., 2004 Mar, In : Experimental Biology and Medicine. 229, 3, p. 247-254 8 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)

Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans.

H., T., N, O., C., S., A., Y., R., Y., K., I., M., N., E., I., T., Y. & Osakabe, N., 2004 Mar 1, In : Exp. Biol. Med.. 229, p. 247-254

Research output: Contribution to journalArticle

105 Citations (Scopus)

Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice

Ito, M., Kudo, N., Miyake, Y., Imai, T., Unno, T., Yamashita, Y., Hirota, Y., Ashida, H. & Osakabe, N., 2017 Nov 1, In : Experimental Gerontology. 98, p. 120-123 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Flavan-3-ol fraction from cocoa powder promotes mitochondrial biogenesis in skeletal muscle in mice

Watanabe, N., Inagawa, K., Shibata, M. & Osakabe, N., 2014 Apr 5, In : Lipids in Health and Disease. 13, 1, 64.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Green tea extract and black tea extract differentially influence cecal levels of short-chain fatty acids in rats

Unno, T. & Osakabe, N., 2018 Jan 1, (Accepted/In press) In : Food Science and Nutrition.

Research output: Contribution to journalArticle

5 Citations (Scopus)
4 Citations (Scopus)

Ingestion of Proanthocyanidins Derived from Cacao Inhibits Diabetes-Induced Cataract Formation in Rats

Osakabe, N., Yamagishi, M., Natsume, M., Yasuda, A. & Osawa, T., 2004 Jan, In : Experimental Biology and Medicine. 229, 1, p. 33-39 7 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Ingestion of proanthocyanidins derived from cacao inhibits diabetes-induced cataract formation in rats.

N, O., M., Y., M, N., A, Y., T., O. & Osakabe, N., 2004 Jan 1, In : Exp. Biol. Med.. 229, p. 33-39

Research output: Contribution to journalArticle

46 Citations (Scopus)

Inhibitory effects of conjugated epicatechin metabolites on peroxynitrite-mediated nitrotyrosine formation

Natsume, M., Osakabe, N., Yasuda, A., Osawa, T. & Terao, J., 2008 Jan 1, In : Journal of Clinical Biochemistry and Nutrition. 42, 1, p. 50-53 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Inhibitory Effects of Conjugated Epicatechin Metabolites on Peroxynitrite-mediated Nitrotyrosine Formation.

Natsume, M., Terao, M. N. N. A. T. J. & Osakabe, N., 2008 Jan 1, In : Jounal of Clinical Biochemistry and Nutririon.. 42, p. 50-53

Research output: Contribution to journalArticle

10 Citations (Scopus)

In vitro antioxidative activity of ( - )-epicatechin glucuronide metabolites present in human and rat plasma

Natsume, M., Osakabe, N., Yasuda, A., Baba, S., Tokunaga, T., Kondo, K., Osawa, T. & Terao, J., 2004 Dec 1, In : Free Radical Research. 38, 12, p. 1341-1348 8 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

In vitro antioxidative activity of (-)-epicatechin glucuronide metabolites present in human and rat plasma.

M., N., N, O., A., Y., S., B., T., T., K., K., T., O., J., T. & Osakabe, N., 2004 Dec 1, In : Free Radic. Res.. 38, p. 1341-1348

Research output: Contribution to journalArticle

51 Citations (Scopus)

In vivo comparison of the bioavailability of (+)-catechin, (-)-epicatechin and their mixture in orally administered rats

Baba, S., Osakabe, N., Natsume, M., Muto, Y., Takizawa, T. & Terao, J., 2001 Nov 26, In : Journal of Nutrition. 131, 11, p. 2885-2891 7 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

Onset of a hypotensive effect following ingestion of flavan 3-ols involved in the activation of adrenergic receptors

Saito, A., Inagawa, K., Ebe, R., Fukase, S., Horikoshi, Y., Shibata, M. & Osakabe, N., 2016 Oct 1, In : Free Radical Biology and Medicine. 99, p. 584-592 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
94 Citations (Scopus)

Physiological activities of polyphenols in Theobroma cacao~Cacao polyphenols prevent atherosclerosis~

Osakabe, N., Natsume, M., Baba, S., Yasuda, A., Yamagishi, M., Terao, J. & Osawa, T., 2003 Nov 15, In : 1st International Conference on Polyphenols and Health(ICPH).

Research output: Contribution to journalArticle

Physiological activity of cacao polyphenols

N, O., N., O., S., B., M., Y., T., T., T., T. J. O. & Osakabe, N., 2005 Dec 15, In : Default journal.

Research output: Contribution to journalArticle

Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder

Baba, S., Natsume, M., Yasuda, A., Nakamura, Y., Tamura, T., Osakabe, N., Kanegae, M. & Kondo, K., 2007 Jun 1, In : Journal of Nutrition. 137, 6, p. 1436-1441 6 p.

Research output: Contribution to journalArticle

147 Citations (Scopus)

Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder.

S., B., M., N., A., Y., Y., N., T., T., M., K., K., K., N., O. & Osakabe, N., 2007 Jan 1, In : J. Nutr.. 137, p. 1436-1441

Research output: Contribution to journalArticle

147 Citations (Scopus)

Polyphenol analysis in black tea with a carbon nanotube electrode

Murakami, S., Takahashi, S., Muguruma, H., Osakabe, N., Inoue, H. & Ohsawa, T., 2019 Jan 1, In : Analytical Sciences. 35, 5, p. 529-534 6 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
1 Citation (Scopus)

Possible mechanisms of postprandial physiological alterations following flavan 3-ol ingestion

Osakabe, N. & Terao, J., 2018 Mar 1, In : Nutrition Reviews. 76, 3, p. 174-186 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects

Hatano, T., Miyatake, H., Natsume, M., Osakabe, N., Takizawa, T., Ito, H. & Yoshida, T., 2002 Apr 8, In : Phytochemistry. 59, 7, p. 749-758 10 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)

Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects.

T., H., H., M., M., N., N, O., T, T., H., I., T., Y. & Osakabe, N., 2002 Apr 1, In : Phytochemistry. 59, p. 749-758

Research output: Contribution to journalArticle

152 Citations (Scopus)

Procyanidins in Theobroma cacao reduce plasma cholesterol levels in high cholesterol-fed rats

Osakabe, N. & Yamagishi, M., 2009 Sep 1, In : Journal of Clinical Biochemistry and Nutrition. 45, 2, p. 131-136 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Procyanidins in Theobroma cacao Reduce Plasma Cholesterol Levels in High Cholesterol-Fed Rats.

Osakabe, N. & Yamagishi, M., 2009 Aug 28, In : Jounal of Clinical Biochemstry and Nutrition.. 45, p. 131-136

Research output: Contribution to journalArticle

15 Citations (Scopus)

Pulmonary exposure to diesel exhaust particles enhances fatty change of the liver in obese diabetic mice

Tomaru, M., Takano, H., Inoue, K. I., Yanagisawa, R., Osakabe, N., Yasuda, A., Shimada, A., Kato, Y. & Uematsu, H., 2007 Jan 1, In : International Journal of Molecular Medicine. 19, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Recent Topics of Cacao Polyphenols on Metabolic Syndrome

Osakabe, N., 2007 Sep 14, In : Bio Korea 2007.

Research output: Contribution to journalArticle

Responses to a single dose of different polyphenols on the microcirculation and systemic circulation in rats

Aruga, N., Toriigahara, M., Shibata, M., Ishii, T., Nakayama, T. & Osakabe, N., 2014 Sep 1, In : Journal of Functional Foods. 10, p. 355-363 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)