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Research Output 1985 2019

  • 4297 Citations
  • 40 h-Index
  • 163 Article
  • 2 Review article
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2019

Catalytic Enantioselective Synthesis of N-C Axially Chiral Sulfonamides through Chiral Palladium-Catalyzed N-Allylation

Kikuchi, Y., Nakamura, C., Matsuoka, M., Asami, R. & Kitagawa, O., 2019 Jun 21, In : Journal of Organic Chemistry. 84, 12, p. 8112-8120 9 p.

Research output: Contribution to journalArticle

Allylation
Sulfonamides
Palladium
Ligands
Derivatives

Chirality-dependent halogen bonds in axially chiral quinazolin-4-one derivatives bearing: Ortho -halophenyl groups

Imai, T., Niijima, E., Terada, S., Wzorek, A., Soloshonok, V. A., Hori, A. & Kitagawa, O., 2019 Jan 1, In : CrystEngComm. 21, 22, p. 3385-3389 5 p.

Research output: Contribution to journalArticle

Bearings (structural)
Halogens
Chirality
chirality
halogens
1 Citation (Scopus)

N-C Axially Chiral Compounds with an ortho-Fluoro Substituent and Steric Discrimination between Hydrogen and Fluorine Atoms Based on a Diastereoselective Model Reaction

Iida, A., Matsuoka, M., Hasegawa, H., Vanthuyne, N., Farran, D., Roussel, C. & Kitagawa, O., 2019 Mar 15, In : Journal of Organic Chemistry. 84, 6, p. 3169-3175 7 p.

Research output: Contribution to journalArticle

Fluorine
Hydrogen
Atoms
Bearings (structural)
Allylation
2018
2 Citations (Scopus)

N−C Axially Chiral Anilines: Electronic Effect on Barrier to Rotation and A Remote Proton Brake

Iwasaki, Y., Morisawa, R., Yokojima, S., Hasegawa, H., Roussel, C., Vanthuyne, N., Caytan, E. & Kitagawa, O., 2018 Mar 20, In : Chemistry - A European Journal. 24, 17, p. 4453-4458 6 p.

Research output: Contribution to journalArticle

Aniline Compounds
Aniline
Brakes
Protons
Design for testability
2 Citations (Scopus)

The self-disproportionation of enantiomers (SDE) of α-amino acid derivatives: facets of steric and electronic properties

Hosaka, T., Imai, T., Wzorek, A., Marcinkowska, M., Kolbus, A., Kitagawa, O., Soloshonok, V. A. & Klika, K. D., 2018 Jan 1, (Accepted/In press) In : Amino Acids.

Research output: Contribution to journalArticle

Enantiomers
Electronic properties
Derivatives
Amino Acids
Esters
1 Citation (Scopus)
Bearings (structural)
Quinazolinones
Chirality
Alkylation
Derivatives
2017
8 Citations (Scopus)

Diastereoselective α-Alkylation of Metallo Enamines Generated from N-C Axially Chiral Mebroqualone Derivatives

Matsuoka, M., Goto, M., Wzorek, A., Soloshonok, V. A. & Kitagawa, O., 2017 May 19, In : Organic Letters. 19, 10, p. 2650-2653 4 p.

Research output: Contribution to journalArticle

Chirality
alkylation
Alkylation
chirality
halides
6 Citations (Scopus)

Possible Case of Halogen Bond-Driven Self-Disproportionation of Enantiomers (SDE) via Achiral Chromatography

Terada, S., Hirai, M., Honzawa, A., Kitagawa, O., Kamizela, A., Wzorek, A. & Soloshonok, V. A., 2017 Oct 17, In : Chemistry - A European Journal. 23, 58, p. 14631-14638 8 p.

Research output: Contribution to journalArticle

Halogens
Enantiomers
Chromatography
Chirality
Hydrogen bonds
1 Citation (Scopus)

Specific reactivity of 2,4,6-tri-tert-butylanilide anions and its application to benzylation reagent

Yamada, T., Tsukagoshi, S. & Kitagawa, O., 2017 Jan 25, In : Tetrahedron Letters. 58, 4, p. 317-320 4 p.

Research output: Contribution to journalArticle

Anilides
Imidoesters
Anions
Alkylation
Ethers
2016
14 Citations (Scopus)

Catalytic Enantioselective Synthesis of N-C Axially Chiral Mebroqualone and Its Derivatives through Reductive Asymmetric Desymmetrization

Hirai, M., Terada, S., Yoshida, H., Ebine, K., Hirata, T. & Kitagawa, O., 2016 Nov 4, In : Organic Letters. 18, 21, p. 5700-5703 4 p.

Research output: Contribution to journalArticle

Quinazolinones
Enantioselectivity
Derivatives
catalysts
Catalysts
15 Citations (Scopus)

Catalytic Enantioselective Synthesis of N-C Axially Chiral Phenanthridin-6-one Derivatives

Hirata, T., Takahashi, I., Suzuki, Y., Yoshida, H., Hasegawa, H. & Kitagawa, O., 2016 Jan 4, In : Journal of Organic Chemistry. 81, 1, p. 318-323 6 p.

Research output: Contribution to journalArticle

Bearings (structural)
Amination
Enantioselectivity
Nitrogen
Derivatives
10 Citations (Scopus)

Chiral additive induced self-disproportionation of enantiomers under MPLC conditions: Preparation of enantiomerically pure samples of 1-(aryl)ethylamines from racemates

Goto, M., Tateishi, K., Ebine, K., Soloshonok, V. A., Roussel, C. & Kitagawa, O., 2016 May 1, In : Tetrahedron Asymmetry. 27, 7-8, p. 317-321 5 p.

Research output: Contribution to journalArticle

Ethylamines
Enantiomers
enantiomers
preparation
elution
2015
35 Citations (Scopus)

A comprehensive examination of the self-disproportionation of enantiomers (SDE) of chiral amides via achiral, laboratory-routine, gravity-driven column chromatography

Suzuki, Y., Han, J., Kitagawa, O., Aceña, J. L., Klika, K. D. & Soloshonok, V. A., 2015, In : RSC Advances. 5, 4, p. 2988-2993 6 p.

Research output: Contribution to journalArticle

Column chromatography
Enantiomers
Amides
Gravitation
Chromatography
7 Citations (Scopus)

Enantioselective synthesis of N-C axially chiral indoles through chiral palladium-catalyzed 5-endo-hydroaminocyclization

Morimoto, Y., Shimizu, S., Mokuya, A., Ototake, N., Saito, A. & Kitagawa, O., 2015 Feb 20, (Accepted/In press) In : Tetrahedron.

Research output: Contribution to journalArticle

Aniline Compounds
Indoles
Chirality
Enantioselectivity
Palladium
7 Citations (Scopus)

Relationship between rotational barriers and structures in N-C axially chiral 3,4-dihydroquinolin-2-one and 3,4-dihydrobenzoquinolin-2-one

Suzuki, Y., Takahashi, I., Dobashi, Y., Hasegawa, H., Roussel, C. & Kitagawa, O., 2015 Jan 1, In : Tetrahedron Letters. 56, 1, p. 132-135 4 p.

Research output: Contribution to journalArticle

Ground state
Crystal structure
Nuclear magnetic resonance
X rays
3,4-dihydroquinolin-2-one
8 Citations (Scopus)

The synthesis of optically active N-C axially chiral tetrahydroquinoline and its response to an acid-accelerated molecular rotor

Suzuki, Y., Kageyama, M., Morisawa, R., Dobashi, Y., Hasegawa, H., Yokojima, S. & Kitagawa, O., 2015 Jul 18, In : Chemical Communications. 51, 56, p. 11229-11232 4 p.

Research output: Contribution to journalArticle

Sulfonic Acids
Methane
Rotors
Acids
1,2,3,4-tetrahydroquinoline
2014
30 Citations (Scopus)

Asymmetric synthesis of atropisomeric compounds with an N-C chiral axis

Takahashi, I., Suzuki, Y. & Kitagawa, O., 2014 Jan 1, In : Organic Preparations and Procedures International. 46, 1, p. 1-23 23 p.

Research output: Contribution to journalArticle

2013
17 Citations (Scopus)

Chiral initiator-induces self-disproportionation of enantiomers via achiral chromatography: Application to enantiomer separation of racemate

Tateishi, K., Tsukagoshi, S., Nakamura, T., Watanabe, S., Soloshonok, V. A. & Kitagawa, O., 2013 Sep 18, In : Tetrahedron Letters. 54, 38, p. 5220-5223 4 p.

Research output: Contribution to journalArticle

Enantiomers
Chromatography

Rotational isomerism in 2,4,6-tri-tert-butylanilides

Ototake, N., Takahashi, I., Tsukagoshi, S., Maeda, T. & Kitagawa, O., 2013 Jan 21, In : Tetrahedron. 69, 3, p. 1013-1016 4 p.

Research output: Contribution to journalArticle

Anilides
Isomerization
Hydrogen bonds
Heating
2,4,6-tri-tert-butylanilide
4 Citations (Scopus)

Unique structural properties of 2,4,6-tri-tert-butylanilide: Isomerization and switching between separable amide rotamers through the reaction of anilide enolates

Tsukagoshi, S., Ototake, N., Ohnishi, Y., Shimizu, M. & Kitagawa, O., 2013 May 17, In : Chemistry - A European Journal. 19, 21, p. 6845-6850 6 p.

Research output: Contribution to journalArticle

Anilides
Isomerization
Amides
Structural properties
Acids
2012
22 Citations (Scopus)

Catalytic enantioselective synthesis of atropisomeric 2-aryl-4-quinolinone derivatives with an N-C chiral axis

Takahashi, I., Morita, F., Kusagaya, S., Fukaya, H. & Kitagawa, O., 2012 Dec 15, In : Tetrahedron: Asymmetry. 23, p. 1657-1662

Research output: Contribution to journalArticle

22 Citations (Scopus)

Catalytic enantioselective synthesis of atropisomeric 2-aryl-4-quinolinone derivatives with an N-C chiral axis

Takahashi, I., Morita, F., Kusagaya, S., Fukaya, H. & Kitagawa, O., 2012 Dec 31, In : Tetrahedron Asymmetry. 23, 24, p. 1657-1662 6 p.

Research output: Contribution to journalArticle

4-Quinolones
Amination
aniline
ketones
Derivatives

Catalytic Enantioselective Synthesis of Atropisomeric 4-Quinolinones with an N-C Chiral axis

Takahashi, I., Fumika, F., Morita, M., Izumi, S. & Kitagawa, O., 2012 Oct 30, In : Default journal.

Research output: Contribution to journalArticle

Enantiomer Enrichment of Non-racemic Chiral Amine Derivatives through Achiral Chromatography

Tateishi, K., Nakamura, T., Tsukagoshi, S. & Kitagawa, O., 2012 May 17, In : Default journal.

Research output: Contribution to journalArticle

Reversible Interconversion between Rotational Isomers of 2,4,6-Tri-tert-butylanilides

Tsukagoshi, S., Yusuke, Y., Ohnishi, O. & Kitagawa, O., 2012 Oct 30, In : Default journal.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Self-disproportionation of enantiomers of non-racemic chiral amine derivatives through achiral chromatography

Nakamura, T., Tateishi, K., Tsukagoshi, S., Hashimoto, S., Watanabe, S., Soloshonok, V. A., Aceña, J. L. & Kitagawa, O., 2012 May 27, In : Tetrahedron. 68, 21, p. 4013-4017 5 p.

Research output: Contribution to journalArticle

Enantiomers
Chromatography
Amines
Derivatives
Acetamides
107 Citations (Scopus)

Self-disproportionation of enantiomers via achiral chromatography: A warning and an extra dimension in optical purifications

Soloshonok, V. A., Roussel, C., Kitagawa, O. & Sorochinsky, A. E., 2012 Jun 7, In : Chemical Society Reviews. 41, 11, p. 4180-4188 9 p.

Research output: Contribution to journalArticle

Enantiomers
Chromatography
Purification
Chirality
Bearings (structural)
107 Citations (Scopus)

Self-disproportionation of enantiomers via achiral chromatography: a warning and an extra dimension in optical purifications

Soloshono, V., Roussel, C., Kitagawa, O., Alex, A. & Sorochinsky, E., 2012 Jun 2, In : Chem. Soc. Rev.. 41, p. 4180-4188

Research output: Contribution to journalArticle

10 Citations (Scopus)

Studies on rotational barriers of N-C axially chiral compounds: Increase in the rotational barrier by aromatization

Suzumura, N., Kageyama, M., Kamimura, D., Inagaki, T., Dobashi, Y., Hasegawa, H., Fukaya, H. & Kitagawa, O., 2012 Aug 15, In : Tetrahedron Letters. 53, 33, p. 4332-4336 5 p.

Research output: Contribution to journalArticle

Aromatization
Discrete Fourier transforms
Nitrogen
10 Citations (Scopus)

Studies on rotational barriers of N-C axially chiral compounds: increase in the rotational barrier by aromatization

Suzumura, N., Kageyama, M., Kamimura, D., Inagak, T., Dobashi, Y., Hasegawa, H., Fukaya, H. & Kitagawa, O., 2012 Aug 1, In : Tetrahedron Lett. 53, p. 4332-4336

Research output: Contribution to journalArticle

Study on Rotational Barrier of N-C Axially Chiral Compounds: Remarkable Increase in the ROtational Barrier by Aromatization

Suzumura, N., Kageyama, M., Dobashi, Y. & Kitagawa, O., 2012 May 17, In : Default journal.

Research output: Contribution to journalArticle

2011
11 Citations (Scopus)
Anilides
Lactams
Derivatives
Indoles
Amination
19 Citations (Scopus)

Intramolecular Diels-Alder reaction of N-allyl 2-furoyl amides: Effect of steric strain and amide rotational isomerism

Nakamura, M., Takahashi, I., Yamada, S., Dobashi, Y. & Kitagawa, O., 2011 Jan 5, In : Tetrahedron Letters. 52, 1, p. 53-55 3 p.

Research output: Contribution to journalArticle

Amides
Cyclization
Discrete Fourier transforms
Nitrogen
Atoms
19 Citations (Scopus)

Intramolecular Diels-Alder Reaction of N-Allyl 2-Furoyl Amides: Effect of Steric Strain and Amide Rotational Isomerism

Nakamura, M., Takahashi, I., Yamada, S., Dobashi, Y. & Kitagawa, O., 2011 Jan 1, In : Tetrahedron Lett. 52, p. 53-55

Research output: Contribution to journalArticle

8 Citations (Scopus)

Notable structural property of 2,4,6-Tri- tert -butylanilide enolates: Interconversion between the rotamers and their reactivity

Ohnishi, Y., Sakai, M., Nakao, S. & Kitagawa, O., 2011 Jun 3, In : Organic Letters. 13, 11, p. 2840-2843 4 p.

Research output: Contribution to journalArticle

Anilides
Lithium
Structural properties
reactivity
lithium
7 Citations (Scopus)

Notable Structural Property of 2,4,6-Tri-tert-butylanilide Enolates: Interconversion between the Rotamers and Their Reactivity

Ohnishi, Y., Sakai, M., Nakao, S. & Kitagawa, O., 2011 May 20, In : Organic Letters. 13, p. 2840-2843

Research output: Contribution to journalArticle

2010
44 Citations (Scopus)

Atropisomeric lactam chemistry: catalytic enantioselective synthesis, application to asymmetric enolate chemistry and synthesis of key intermediates for NET inhibitors

Takahashi, M., Tanabe, H., Nakamura, T., Kuribara, D., Yamazaki, T. & Kitagawa, O., 2010 Jan 2, In : Tetrahedron. 66, 1, p. 288-296 9 p.

Research output: Contribution to journalArticle

Lactams
Anilides
Silica Gel
Lithium
Purification
44 Citations (Scopus)

Atropisomeric lactam chemistry: catalytic enantioselective synthesis, application to asymmetric enolate chemistry and synthesis of key intermediates for NET inhibitors

Takahashi, M., Tanabe, H., Nakamura, T., Kuribara, D., Yamazaki, T. & Kitagawa, O., 2010 Jan 5, In : Tetrahedron. 66, p. 288-296

Research output: Contribution to journalArticle

40 Citations (Scopus)

Catalytic enantioselective synthesis of atropisomeric indoles with an N-C chiral axis

Ototake, N., Morimoto, Y., Mokuya, A., Fukaya, H., Shida, Y. & Kitagawa, O., 2010 Jun 18, In : Chemistry - A European Journal. 16, 23, p. 6752-6755 4 p.

Research output: Contribution to journalArticle

Indoles
palladium chloride
1,3-benzodioxole
40 Citations (Scopus)

Catalytic Enantioselective Synthesis of Atropisomeric Indoles with an N-C Chiral Axis.

Ototake, N., Morimoto, Y., Mokuya, A., Fukaya, H., Shida, Y. & Kitagawa, O., 2010 May 13, In : Chem. Eur. J.. 16, p. 6752-6755

Research output: Contribution to journalArticle

2009
14 Citations (Scopus)

Highly selective stereodivergent synthesis of separable amide rotamers, by using Pd chemistry, and their thermodynamic behavior

Ototake, N., Nakamura, M., Dobashi, Y., Fukaya, H. & Kitagawa, O., 2009 May 11, In : Chemistry - A European Journal. 15, 20, p. 5090-5095 6 p.

Research output: Contribution to journalArticle

Anilides
Allylation
Amides
Thermodynamics
Isomers

Highly Selective Stereodivergent Synthesis of Separable Amide Rotamers Using Pd Chemistry and Their Thermodynamic Behaviors.

Ototake, N., Nakamura, M., Dobashi, Y., Fukaya, H. & Kitagawa, O., 2009 May 1, In : Chem. Eur. J.. 15, p. 5090-5095

Research output: Contribution to journalArticle

2008
26 Citations (Scopus)

Catalytic enantioselective synthesis of key intermediates for NET inhibitors using atropisomeric lactam chemistry

Kitagawa, O., Kurihara, D., Tanabe, H., Shibuya, T. & Taguchi, T., 2008 Jan 14, In : Tetrahedron Letters. 49, 3, p. 471-474 4 p.

Research output: Contribution to journalArticle

Lactams
Enantioselectivity
Alkylation
Hydration

Stereoselective synthesis of separable amide rotamers using p-allyl-Pd catalyst and their thermodynamic behavior

Ototake, N., Taguchi, T. & Kitagawa, O., 2008 Aug 1, In : Tetrahedron Lett.. 49, p. 5458-5460

Research output: Contribution to journalArticle

7 Citations (Scopus)

Stereoselective synthesis of separable amide rotamers using π-allyl-Pd catalyst and their thermodynamic behavior

Ototake, N., Taguchi, T. & Kitagawa, O., 2008 Sep 15, In : Tetrahedron Letters. 49, 38, p. 5458-5460 3 p.

Research output: Contribution to journalArticle

Allylation
Amides
Thermodynamics
Catalysts
Anilides
2007

Highly Enantioselctive Synthesis of Atropisomeric Lactams through Catalytic Asymmetric Buchwald-Hartwig Amination

Kitagawa, O., Tanabe, H. & Taguchi, T., 2007 Aug 23, In : Default journal.

Research output: Contribution to journalArticle

2006
18 Citations (Scopus)
Allylation
Diamide
Enantioselectivity
Derivatives
Catalysts
92 Citations (Scopus)

Highly enantioselective synthesis of atropisomeric anilide derivatives through catalytic asymmetric N-arylation: Conformational analysis and application to asymmetric enolate chemistry

Kitagawa, O., Yoshikawa, M., Tanabe, H., Morita, T., Takahashi, M., Dobashi, Y. & Taguchi, T., 2006 Oct 4, In : Journal of the American Chemical Society. 128, 39, p. 12923-12931 9 p.

Research output: Contribution to journalArticle

Anilides
Lactams
Derivatives
Amination
Enantioselectivity
92 Citations (Scopus)

Highly Enantioselective Synthesis of Atropisomeric Anilide Derivatives through Catalytic Asymmetric N-Arylation: Conformational Analysis and Application to Asymmetric Enolate Chemistry.

Kitagawa, O., Yoshikawa, M., Tanabe, H., Morita, T., Takahashi, M., Dobashi, Y. & Taguchi, T., 2006 Sep 7, In : J. Am. Chem. Soc.. 128, p. 12923-12931

Research output: Contribution to journalArticle