Yoshihisa Hirota

  • 316 Citations
  • 6 h-Index
20082019
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Research Output 2008 2019

  • 316 Citations
  • 6 h-Index
  • 18 Article
  • 1 Comment/debate
  • 1 Review article
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Article
2019
2 Citations (Scopus)

Acylated anthocyanins derived from purple carrot (: Daucus carota L.) induce elevation of blood flow in rat cremaster arteriole

Tsutsumi, A., Horikoshi, Y., Fushimi, T., Saito, A., Koizumi, R., Fujii, Y., Hu, Q. Q., Hirota, Y., Aizawa, K. & Osakabe, N., 2019 Mar 1, In : Food and Function. 10, 3, p. 1726-1735 10 p.

Research output: Contribution to journalArticle

Daucus carota
carrots
blood flow
cyanidin
glycosides

Elucidation of the interaction between flavan-3-ols and bovine serum albumin and its effect on their in-vitro cytotoxicity

Fujii, Y., Suhara, Y., Sukikara, Y., Teshima, T., Hirota, Y., Yoshimura, K. & Osakabe, N., 2019 Oct 11, In : Molecules. 24, 20, 3667.

Research output: Contribution to journalArticle

Open Access
Cytotoxicity
Bovine Serum Albumin
albumins
serums
Cell culture
2018

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice

Hirota, Y., Nakagawa, K., Isomoto, K., Sakaki, T., Kubodera, N., Kamao, M., Osakabe, N., Suhara, Y. & Okano, T., 2018 Oct 1, In : PLoS One. 13, 10, e0199856.

Research output: Contribution to journalArticle

1alpha-hydroxycholecalciferol
vitamin D
bone formation
Bone
bones
2 Citations (Scopus)

Generation of 1,25-dihydroxyvitamin D3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D3 rescued their rachitic phenotypes

Nishikawa, M., Yasuda, K., Takamatsu, M., Abe, K., Nakagawa, K., Tsugawa, N., Hirota, Y., Tanaka, K., Yamashita, S., Ikushiro, S., Suda, T., Okano, T. & Sakaki, T., 2018 Jan 1, (Accepted/In press) In : Journal of Steroid Biochemistry and Molecular Biology.

Research output: Contribution to journalArticle

Calcifediol
Calcitriol
Plasmas
Minerals
Bone
2017
1 Citation (Scopus)

Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice

Ito, M., Kudo, N., Miyake, Y., Imai, T., Unno, T., Yamashita, Y., Hirota, Y., Ashida, H. & Osakabe, N., 2017 Nov 1, In : Experimental Gerontology. 98, p. 120-123 4 p.

Research output: Contribution to journalArticle

Muscle
Suspensions
Cocoa
Ligases
Ubiquitin
2 Citations (Scopus)

Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice

Hirota, Y., Nakagawa, K., Mimatsu, S., Sawada, N., Sakaki, T., Kubodera, N., Kamao, M., Tsugawa, N., Suhara, Y. & Okano, T., 2017 Jan 29, In : Biochemical and Biophysical Research Communications. 483, 1, p. 359-365 7 p.

Research output: Contribution to journalArticle

Calcitriol
Cartilage
Vitamin D
Calcitriol Receptors
Calcium
6 Citations (Scopus)
2 Citations (Scopus)

Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities

Sakane, R., Kimura, K., Hirota, Y., Ishizawa, M., Takagi, Y., Wada, A., Kuwahara, S., Makishima, M. & Suhara, Y., 2017 Nov 1, In : Bioorganic and Medicinal Chemistry Letters. 27, 21, p. 4881-4884 4 p.

Research output: Contribution to journalArticle

Vitamin K
Derivatives
Vitamin K 2
Oxidative stress
Bioactivity
2015
17 Citations (Scopus)

Functional characterization of the vitamin K<inf>2</inf> biosynthetic enzyme UBIAD1

Hirota, Y., Nakagawa, K., Sawada, N., Okuda, N., Suhara, Y., Uchino, Y., Kimoto, T., Funahashi, N., Kamao, M., Tsugawa, N. & Okano, T., 2015 Apr 15, In : PLoS One. 10, 4, e0125737.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Vitamin K 2
menaquinones
Enzymes
enzymes
4 Citations (Scopus)

Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

Suhara, Y., Hirota, Y., Hanada, N., Nishina, S., Eguchi, S., Sakane, R., Nakagawa, K., Wada, A., Takahashi, K., Tokiwa, H. & Okano, T., 2015 Sep 10, In : Journal of Medicinal Chemistry. 58, 17, p. 7088-7092 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

YY1 positively regulates human UBIAD1 expression

Funahashi, N., Hirota, Y., Nakagawa, K., Sawada, N., Watanabe, M., Suhara, Y. & Okano, T., 2015 May 1, In : Biochemical and Biophysical Research Communications. 460, 2, p. 238-244 7 p.

Research output: Contribution to journalArticle

Vitamin K 3
Vitamin K
Vitamin K 1
Messenger RNA
Dimethylallyltranstransferase
2014
19 Citations (Scopus)

Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice

Nakagawa, K., Sawada, N., Hirota, Y., Uchino, Y., Suhara, Y., Hasegawa, T., Amizuka, N., Okamoto, T., Tsugawa, N., Kamao, M., Funahashi, N. & Okano, T., 2014, In : PLoS One. 9, 8, p. e104078

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Vitamin K 2
menaquinones
embryogenesis
coenzyme Q10
2013
44 Citations (Scopus)

Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats

Hirota, Y., Tsugawa, N., Nakagawa, K., Suhara, Y., Tanaka, K., Uchino, Y., Takeuchi, A., Sawada, N., Kamao, M., Wada, A., Okitsu, T. & Okano, T., 2013 Nov 15, In : Journal of Biological Chemistry. 288, 46, p. 33071-33080 10 p.

Research output: Contribution to journalArticle

Vitamin K 1
Vitamin K 3
Vitamin K 2
Dimethylallyltranstransferase
Rats

The UBIAD1 Prenyltransferase Links Menaquinone-4 Synthesis to Cholesterol Metabolic Enzymes. [HumanMutation 34, 2, 316-329 (DOI 10.1002/humu.22230)]

Nickerson, M. L., Bosley, A. D., Weiss, J. S., Kostiha, B. N., Hirota, Y., Brandt, W., Esposito, D., Kinoshita, S., Wessjohann, L., Morham, S. G., Andresson, T., Kruth, H. S., Okano, T. & Dean, M., 2013 Jul, In : Human Mutation. 34, 7, p. 1046 1 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

The UBIAD1 Prenyltransferase Links Menaquione-4 Synthesis to Cholesterol Metabolic Enzymes

Nickerson, M. L., Bosley, A. D., Weiss, J. S., Kostiha, B. N., Hirota, Y., Brandt, W., Esposito, D., Kinoshita, S., Wessjohann, L., Morham, S. G., Andresson, T., Kruth, H. S., Okano, T. & Dean, M., 2013 Feb, In : Human Mutation. 34, 2, p. 317-329 13 p.

Research output: Contribution to journalArticle

2010
154 Citations (Scopus)

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme

Nakagawa, K., Hirota, Y., Sawada, N., Yuge, N., Watanabe, M., Uchino, Y., Okuda, N., Shimomura, Y., Suhara, Y. & Okano, T., 2010 Nov 4, In : Nature. 468, 7320, p. 117-121 5 p.

Research output: Contribution to journalArticle

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme.

Hirota, Y., 2010, In : Nature. 468

Research output: Contribution to journalArticle

2008
12 Citations (Scopus)

Design and synthesis of biologically active analogues of vitamin K2: Evaluation of their biological activities with cultured human cell lines

Suhara, Y., Hirota, Y., Nakagawa, K., Kamao, M., Tsugawa, N. & Okano, T., 2008 Mar 15, In : Bioorganic and Medicinal Chemistry. 16, 6, p. 3108-3117 10 p.

Research output: Contribution to journalArticle

Vitamin K 2
Bioactivity
Cells
Carboxylation
Apoptosis