• 5446 Citations
  • 40 h-Index
19942019

Research output per year

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Research Output

  • 5446 Citations
  • 40 h-Index
  • 122 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Short survey
2019

Elucidation of the interaction between flavan-3-ols and bovine serum albumin and its effect on their in-vitro cytotoxicity

Fujii, Y., Suhara, Y., Sukikara, Y., Teshima, T., Hirota, Y., Yoshimura, K. & Osakabe, N., 2019 Oct 11, In : Molecules. 24, 20, 3667.

Research output: Contribution to journalArticle

Open Access
Open Access
3 Citations (Scopus)

Synthesis and in vitro evaluation of novel liver X receptor agonists based on naphthoquinone derivatives

Nishioka, T., Endo-Umeda, K., Ito, Y., Shimoda, A., Takeuchi, A., Tode, C., Hirota, Y., Osakabe, N., Makishima, M. & Suhara, Y., 2019 Nov 26, In : Molecules. 24, 23, 4316.

Research output: Contribution to journalArticle

Open Access

UBIAD1 Plays an Essential Role in the Survival of Pancreatic Acinar Cells

Nakagawa, K., Fujiwara, K., Nishimura, A., Murakami, C., Kawamoto, K., Ichinose, C., Kunitou, Y., Suhara, Y., Okano, T. & Hasegawa, H., 2019 Apr 22, In : International journal of molecular sciences. 20, 8

Research output: Contribution to journalArticle

Open Access
2018

Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice

Nakagawa, Y., Ishimura, K., Oya, S., Kamino, M., Fujii, Y., Nanba, F., Toda, T., Ishii, T., Adachi, T., Suhara, Y. & Osakabe, N., 2018 Jul 1, In : PLoS One. 13, 7, e0201203.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice

Hirota, Y., Nakagawa, K., Isomoto, K., Sakaki, T., Kubodera, N., Kamao, M., Osakabe, N., Suhara, Y. & Okano, T., 2018 Oct 1, In : PLoS One. 13, 10, e0199856.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

Determination of menadione by liquid chromatography-tandem mass spectrometry using pseudo multiple reaction monitoring

Kamao, M., Hirota, Y., Suhara, Y., Tsugawa, N., Nakagawa, K., Okano, T. & Hasegawa, H., 2017, In : Analytical Sciences. 33, 7, p. 863-867 5 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice

Hirota, Y., Nakagawa, K., Mimatsu, S., Sawada, N., Sakaki, T., Kubodera, N., Kamao, M., Tsugawa, N., Suhara, Y. & Okano, T., 2017 Jan 29, In : Biochemical and Biophysical Research Communications. 483, 1, p. 359-365 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Substitution at the C-3 position of catechins has an influence on the binding affinities against serum albumin

Ikeda, M., Ueda-Wakagi, M., Hayashibara, K., Kitano, R., Kawase, M., Kaihatsu, K., Kato, N., Suhara, Y., Osakabe, N. & Ashida, H., 2017 Feb 1, In : Molecules. 22, 2, 314.

Research output: Contribution to journalArticle

6 Citations (Scopus)
9 Citations (Scopus)

Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities

Sakane, R., Kimura, K., Hirota, Y., Ishizawa, M., Takagi, Y., Wada, A., Kuwahara, S., Makishima, M. & Suhara, Y., 2017 Nov 1, In : Bioorganic and Medicinal Chemistry Letters. 27, 21, p. 4881-4884 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

A single oral dose of flavan-3-ols enhances energy expenditure by sympathetic nerve stimulation in mice

Kamio, N., Suzuki, T., Watanabe, Y., Suhara, Y. & Osakabe, N., 2016 Feb 1, In : Free Radical Biology and Medicine. 91, p. 256-263 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The impact of theaflavins on systemic-and microcirculation alterations: The murine and randomized feasibility trials

Saito, A., Nakazato, R., Suhara, Y., Shibata, M., Fukui, T., Ishii, T., Asanuma, T., Mochizuki, K., Nakayama, T. & Osakabe, N., 2016 Jun 1, In : Journal of Nutritional Biochemistry. 32, p. 107-114 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2015

A single oral administration of theaflavins increases energy expenditure and the expression of metabolic genes

Kudo, N., Arai, Y., Suhara, Y., Ishii, T., Nakayama, T. & Osakabe, N., 2015 Sep 16, In : PLoS One. 10, 9, e0137809.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Functional characterization of the vitamin K<inf>2</inf> biosynthetic enzyme UBIAD1

Hirota, Y., Nakagawa, K., Sawada, N., Okuda, N., Suhara, Y., Uchino, Y., Kimoto, T., Funahashi, N., Kamao, M., Tsugawa, N. & Okano, T., 2015 Apr 15, In : PLoS One. 10, 4, e0125737.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

Suhara, Y., Hirota, Y., Hanada, N., Nishina, S., Eguchi, S., Sakane, R., Nakagawa, K., Wada, A., Takahashi, K., Tokiwa, H. & Okano, T., 2015 Sep 10, In : Journal of Medicinal Chemistry. 58, 17, p. 7088-7092 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

YY1 positively regulates human UBIAD1 expression

Funahashi, N., Hirota, Y., Nakagawa, K., Sawada, N., Watanabe, M., Suhara, Y. & Okano, T., 2015 May 1, In : Biochemical and Biophysical Research Communications. 460, 2, p. 238-244 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2014

Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice

Nakagawa, K., Sawada, N., Hirota, Y., Uchino, Y., Suhara, Y., Hasegawa, T., Amizuka, N., Okamoto, T., Tsugawa, N., Kamao, M., Funahashi, N. & Okano, T., 2014, In : PLoS One. 9, 8, p. e104078

Research output: Contribution to journalArticle

19 Citations (Scopus)
2013

Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11

Edson, K. Z., Prasad, B., Unadkat, J. D., Suhara, Y., Okano, T., Peter Guengerich, F. & Rettie, A. E., 2013 Nov 19, In : Biochemistry. 52, 46, p. 8276-8285 10 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance

Li, Q., Qi, J., Wu, Y., Kiyota, H., Tanaka, K., Suhara, Y., Ohrui, H., Suzuki, Y., Vavricka, C. J. & Gao, G. F., 2013 Sep 5, In : Journal of Virology. 87, 18, p. 10016-10024 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats

Hirota, Y., Tsugawa, N., Nakagawa, K., Suhara, Y., Tanaka, K., Uchino, Y., Takeuchi, A., Sawada, N., Kamao, M., Wada, A., Okitsu, T. & Okano, T., 2013 Nov 15, In : Journal of Biological Chemistry. 288, 46, p. 33071-33080 10 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)
2012

Structure-activity relationship of novel menaquinone-4 analogues: Modification of the side chain affects their biological activities

Suhara, Y., Hanada, N., Okitsu, T., Sakai, M., Watanabe, M., Nakagawa, K., Wada, A., Takeda, K., Takahashi, K., Tokiwa, H. & Okano, T., 2012 Feb 23, In : Journal of Medicinal Chemistry. 55, 4, p. 1553-1558 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Structure-Activity Relationship of Novel Menaquinone-4 Analogues: Modification of the Side Chain Affects their Biological Activities

SUHARA, SUHARA., Y., Y., HANADA, HANADA., N., N., OKITSU, OKITSU., T., T., SAKAI, SAKAI., M., M., WATANABE, WATANABE., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA. & T., H. . OKANO., 2012 Jan 17, In : Journal of Medicinal Chemistry. 55, p. 1553-1558

Research output: Contribution to journalArticle

9 Citations (Scopus)
2011

Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: Insights into the biological role of the side chain part of vitamin K

Suhara, Y., Watanabe, M., Motoyoshi, S., Nakagawa, K., Wada, A., Takeda, K., Takahashi, K., Tokiwa, H. & Okano, T., 2011 Jul 14, In : Journal of Medicinal Chemistry. 54, 13, p. 4918-4922 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: Insights into the biological role of the side chain part of vitamin K

SUHARA, SUHARA., Y., Y., WATANABE, WATANABE., M., M., MOTOYOSHI, MOTOYOSHI., S., S., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA., H., H., OKANO, OKANO. & T., T., 2011 Dec 1, In : Default journal. p. 177-177

Research output: Contribution to journalArticle

19 Citations (Scopus)

Synthesis of New Vitamin K Analogues as Steroid and Xenobiotic Receptor Agonists: Insight into the Biological Role of the Side Chain Part of Vitamin K

SUHARA, SUHARA., Y, Y., Y., Y., WATANABE, WATANABE., M., M., MOTOYOSHI, MOTOYOSHI., S., S., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA., H., H., OKANO, OKANO. & T., T., 2011 May 27, In : Jornal of Medicinal Chemistry. 54, p. 4918-4922

Research output: Contribution to journalArticle

19 Citations (Scopus)

Synthesis of novel vitamin K2 analogues with modification at the Ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists

Suhara, Y., Watanabe, M., Nakagawa, K., Wada, A., Ito, Y., Takeda, K., Takahashi, K. & Okano, T., 2011 Jun 23, In : Journal of Medicinal Chemistry. 54, 12, p. 4269-4273 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Synthesis of Novel Vitamin K2 Analogues with Modification at the ω-Terminal Position and their Biological Evaluation as Potent Steroid and Xenobiotic Receptor (SXR) Agonists

SUHARA, SUHARA., Y, Y., Y., Y., WATANABE, WATANABE., M., M., NAKAGWA, NAKAGWA., K., K., WADA, WADA., A., A., ITO, ITO., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., OKANO, OKANO. & T., T., 2011 May 11, In : Jornal of Medicinal Chemistry. 54, p. 4269-4273

Research output: Contribution to journalArticle

7 Citations (Scopus)
2010

Efficient synthesis and biological evaluation of demethyl geranylgeranoic acid derivatives

Wada, A., Wang, F., Suhara, Y., Yamano, Y., Okitsu, T., Nakagawa, K. & Okano, T., 2010 Aug 15, In : Bioorganic and Medicinal Chemistry. 18, 16, p. 5795-5806 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Identification of UBIAD1 as a Novel Human Menaquinone-4 Biosynthesis Enzyme

NAKAGAWA, NAKAGAWA., K, K., K., K., HIROTA, HIROTA., Y., Y., SAWADA, SAWADA., N., N., YUGE, YUGE., WATANABE, WATANABE., M., M., UCHINO, UCHINO., OKUDA, OKUDA., SHIMOMURA, SHIMOMURA., SUHARA, SUHARA., OKANO, OKANO. & T., T., 2010 Nov 1, In : Nature. 468, p. 117-121

Research output: Contribution to journalArticle

164 Citations (Scopus)

Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme

Nakagawa, K., Hirota, Y., Sawada, N., Yuge, N., Watanabe, M., Uchino, Y., Okuda, N., Shimomura, Y., Suhara, Y. & Okano, T., 2010 Nov 4, In : Nature. 468, 7320, p. 117-121 5 p.

Research output: Contribution to journalArticle

164 Citations (Scopus)

Structure-activity relationships in the conversion of vitamin K analogues into menaquinone-4. Substrates essential to the synthesis of menaquinone-4 in cultured human cell lines

Suhara, Y., Wada, A., Tachibana, Y., Watanabe, M., Nakamura, K., Nakagawa, K. & Okano, T., 2010 May 1, In : Bioorganic and Medicinal Chemistry. 18, 9, p. 3116-3124 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Structure-activity Relationships in the Conversion of Vitamin K Analogues into Menaquinone-4. Substrates Essential to the Synthesis of Menaquinone-4 in Cultured Human Cell Lines.

SUHARA, SUHARA., Y, Y., Y., Y., WADA, WADA., A., A., TACHIBANA, TACHIBANA., WATANABE, WATANABE., M., M., NAKAMURA, NAKAMURA., K., K., NAKAGAWA, NAKAGAWA., OKANO, OKANO. & T., T., 2010 Mar 1, In : Bioorganic & Medicinal Chemistry. 18, p. 3116-3124

Research output: Contribution to journalArticle

12 Citations (Scopus)
2009

Elucidation of the mechanism producing menaquinone-4 in osteoblastic cells

Suhara, Y., Wada, A. & Okano, T., 2009 Feb 15, In : Bioorganic and Medicinal Chemistry Letters. 19, 4, p. 1054-1057 4 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Synthesis of 2 -Propoxy-1 ,25- dihydroxyvitamin D3 and Comparison of Its Metabolism by Human CYP24A1 and Rat CYP24A1

SAITO, SAITO., N, N., N., N., SUHARA, SUHARA., Y., Y., ABE, ABE., D., D., KUSUDO, KUSUDO., T., T., OHTA, OHTA., M., M., SAKAKI, SAKAKI., HONZAWA, HONZAWA., S., S., FUJISHIMA, FUJISHIMA., KITTAKA, KITTAKA. & A., A., 2009 Mar 1, In : Bioorganic & Medicinal Chemistry. 17, p. 4296-4301

Research output: Contribution to journalArticle

19 Citations (Scopus)

Synthesis of 2α-propoxy-1α,25-dihydroxyvitamin D3 and comparison of its metabolism by human CYP24A1 and rat CYP24A1

Saito, N., Suhara, Y., Abe, D., Kusudo, T., Ohta, M., Yasuda, K., Sakaki, T., Honzawa, S., Fujishima, T. & Kittaka, A., 2009 Jul 1, In : Bioorganic and Medicinal Chemistry. 17, 13, p. 4296-4301 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2008

Conversion of phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) in mice: Two possible routes for menaquinone-4 accumulation in cerebra of mice

Okano, T., Shimomura, Y., Yamane, M., Suhara, Y., Kamao, M., Sugiura, M. & Nakagawa, K., 2008 Apr 25, In : Journal of Biological Chemistry. 283, 17, p. 11270-11279 10 p.

Research output: Contribution to journalArticle

156 Citations (Scopus)

Conversion of Phylloquinone (Vitamin K1) into Menaquinone-4 (Vitamin K2) in Mice: TWO POSSIBLE ROUTE FOR MENAQUINONE-4 ACCUMULATION IN CEREBRA OF MICE

OKANO, OKANO., T, T., T., T., SHIMOMURA, SHIMOMURA., Y., Y., YAMANE, YAMANE., M., M., SUHARA, SUHARA., KAMAO, KAMAO., SUGIURA, SUGIURA., NAKAGAWA, NAKAGAWA. & K., K., 2008 Nov 1, In : Journal of Biological Chemistry. 283, p. 11270-11279

Research output: Contribution to journalArticle

156 Citations (Scopus)

Conversion of Vitamin K Analogues to Menaquinone-4 in Osteoblastic Cells

SUHARA, SUHARA., Y, Y., Y., Y., KAMAO, KAMAO., M., M., NAKAGAWA, NAKAGAWA., K., K., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2008 Sep 1, In : Proceedings of 30th Annual Meeting of the American Society for Bone and Mineral Research.

Research output: Contribution to journalArticle

Design and synthesis of biologically active analogues of vitamin K2: Evaluation of their biological activities with cultured human cell lines

Suhara, Y., Hirota, Y., Nakagawa, K., Kamao, M., Tsugawa, N. & Okano, T., 2008 Mar 15, In : Bioorganic and Medicinal Chemistry. 16, 6, p. 3108-3117 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Design and Synthesis of Biologically Active Analogues of Vitamin K2: Evaluation of their Biological Activities with Cultured Human Cell Lines

SUHARA, SUHARA., Y, Y., Y., Y., HIROTA, HIROTA., NAKAGAWA, NAKAGAWA., K., K., KAMAO, KAMAO., M., M., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2008 Jan 1, In : Bioorganic & Medicinal Chemistry. 16, p. 3108-3117

Research output: Contribution to journalArticle

12 Citations (Scopus)

Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women

Tsugawa, N., Shiraki, M., Suhara, Y., Kamao, M., Ozaki, R., Tanaka, K. & Okano, T., 2008 Jan 1, In : Journal of Bone and Mineral Metabolism. 26, 1, p. 79-85 7 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Synthesis and development of biologically active fluorescent-labeled vitamin K analogues and monitoring of their subcellular distribution

Suhara, Y., Abe, S., Murakami, A., Shimomura, Y., Nakagawa, K., Kamao, M., Tsugawa, N. & Okano, T., 2008 Sep 8, In : Tetrahedron. 64, 37, p. 8789-8796 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2007
10 Citations (Scopus)

Determination of Fat-Soluble Vitamins in Human Plasma, Breast Milk and Food Samples: Application in Nutrition Survey for Establishment of "Dietary Reference Intakes for Japanese"

KAMAO, KAMAO., M, M., M., M., TSUGAWA, TSUGAWA., N., N., SUHARA, SUHARA., Y., Y., OKANO, OKANO. & T., T., 2007 Mar 1, In : Journal of Health Science. 53, p. 257-262

Research output: Contribution to journalArticle

10 Citations (Scopus)

Efficient Synthesis and Biological Evaluation of -Oxygenated Analogues of Vitamin K2: Study of Modification and Structure-activity Relationship of Vitamin K2 Metabolites

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., KAMAO, KAMAO., M., M., NAKAGAWA, NAKAGAWA., K., K., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2007 Feb 1, In : Bioorganic & Medicinal Chemistry Letters. 17, p. 1622-1625

Research output: Contribution to journalArticle

5 Citations (Scopus)

Efficient synthesis and biological evaluation of ω-oxygenated analogues of vitamin K2: Study of modification and structure-activity relationship of vitamin K2 metabolites

Suhara, Y., Murakami, A., Kamao, M., Mimatsu, S., Nakagawa, K., Tsugawa, N. & Okano, T., 2007 Mar 15, In : Bioorganic and Medicinal Chemistry Letters. 17, 6, p. 1622-1625 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Quantification of fat-soluble vitamins in human breast milk by liquid chromatography-tandem mass spectrometry

Kamao, M., Tsugawa, N., Suhara, Y., Wada, A., Mori, T., Murata, K., Nishino, R., Ukita, T., Uenishi, K., Tanaka, K. & Okano, T., 2007 Nov 15, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 859, 2, p. 192-200 9 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand

Suhara, Y., Oka, S., Kittaka, A., Takayama, H., Waku, K. & Sugiura, T., 2007 Jan 15, In : Bioorganic and Medicinal Chemistry. 15, 2, p. 854-867 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Synthesis and Biological Evaluation of Vitamin K2 Metabolites

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., KAMAO, KAMAO., M., M., MIMATSU, MIMATSU., S., S., NAKAGAWA, NAKAGAWA., K., K., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2007 Sep 1, In : Proceedings of 29th Annual Meeting of the American Society for Bone and Mineral Research.

Research output: Contribution to journalArticle