• 5581 Citations
  • 40 h-Index
1994 …2020

Research output per year

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Research Output

  • 5581 Citations
  • 40 h-Index
  • 123 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Short survey
1994

Lipid A and Related Compounds. XXIX.: Synthesis of Biologically Active N-Acylated L-Asparagine-Containing D-Glucosamine Derivatives Structually Related to Lipid A

SUHARA, SUHARA., Y., Y., ARAKAWA, ARAKAWA., M., M., IKEDA, IKEDA., K., K. & ACHIWA, ACHIWA., 1994 Dec 1, In : Chemical & Pharmaceutical Bulletin. 42, p. 2526-2531

Research output: Contribution to journalArticle

10 Citations (Scopus)

Protective Effect of Sodium L-Malate, an Active Constituent Isolated from Angelicae Radix, on cis-Diamminedichloroplatinum (II)-Induced Toxic Side Effect

SUGIYAMA, SUGIYAMA., K., K., UEDA, UEDA., H., H., SUHARA, SUHARA., Y., Y., KAJIMA, KAJIMA., ICHIO, ICHIO., YOKOTA, YOKOTA. & M., M., 1994 Dec 1, In : Chemical & Pharmaceutical Bulletin. 42, p. 2565-2568

Research output: Contribution to journalArticle

9 Citations (Scopus)
1995
10 Citations (Scopus)
1996

Comparison of the biological activity of synthetic N-acylated asparagine or serine linked monosaccharide lipid A analogs

Shimizu, T., Iwamoto, Y., Yanagihara, Y., Ryoyama, K., Suhara, Y., Ikeda, K. & Achiwa, K., 1996 Jan 1, In : Immunobiology. 196, 4, p. 321-331 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Comparison of the Biological Activity of Synthetic N-Acylated Asparagine or Serine Linked Monosaccharide Lipid A Analogues

SHIMIZU, SHIMIZU., T., T., IWAMOTO, IWAMOTO., Y., Y., YANAGIHARA, YANAGIHARA., RYOYAMA, RYOYAMA., K., K., SUHARA, SUHARA., IKEDA, IKEDA. & ACHIWA, ACHIWA., 1996 Mar 1, In : Immunobiology. 196, p. 321-331

Research output: Contribution to journalArticle

Erratum: Synthesis of a new carbohydrate mimetics: 'Carbopeptoid' containing a C-1 carboxylate and C-2 amino group (Tetrahedron Letters (1996) 37 (1575-1578))

Suhara, Y., Hildreth, J. E. K. & Ichikawa, Y., 1996 Jan 1, In : Tetrahedron Letters. 37, 28, 1 p.

Research output: Contribution to journalComment/debate

Synthesis of a New Carbohydrate Mimetics: "Carbopeptoid" Containing a C-1 Carboxylate and C-2 Amino Group

SUHARA, SUHARA., Y., Y., HILDRETH, HILDRETH., K., J. E. & ICHIKAWA, ICHIKAWA., 1996 Mar 1, In : Tetrahedron Letters. 37, p. 1575-1578

Research output: Contribution to journalArticle

81 Citations (Scopus)

Synthesis of a new carbohydrate mimetics "carbopeptoid"

SUHARA, SUHARA., Y., Y. & ICHIKAWA, ICHIKAWA., 1996 Mar 24, In : Book of Abstracts, 211th ACS National Meeting.

Research output: Contribution to journalArticle

Synthesis of Sulfated beta-1,6-Linked Oligosaccharide Mimetics: A Novel Potent Inhibitor of HIV Replication

SUHARA, SUHARA., Y., Y., ICHIKAWA, ICHIKAWA., M., M., HILDRETH, HILDRETH. & K., J. E., 1996 Apr 1, In : Tetrahedron Letters. 37, p. 2459-2552

Research output: Contribution to journalArticle

56 Citations (Scopus)

Synthesis of sulfated β-1,6-linked oligosaccharide mimetics: A novel potent inhibitor of HIV replication

Suhara, Y., Ichikawa, M., Hildreth, J. E. K. & Ichikawa, Y., 1996 Apr 8, In : Tetrahedron Letters. 37, 15, p. 2549-2552 4 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)
1997

Peptide-Sugar Hybrid: Like Peptide, Like Oligosaccharide

SUHARA, SUHARA., Y., Y., IZUMI, IZUMI., M., M., ICHIKAWA, ICHIKAWA., PENNO, PENNO. & M.B., M. B., 1997 Nov 1, In : Tetrahedron Letters. 38, p. 7167-7170

Research output: Contribution to journalArticle

26 Citations (Scopus)

Peptide-sugar hybrids: Like peptide, like oligosaccharide

Suhara, Y., Izumi, M., Ichikawa, M., Penno, M. B. & Ichikawa, Y., 1997 Oct 13, In : Tetrahedron Letters. 38, 41, p. 7167-7170 4 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
1998

1-N-Iminosugars: Potent and selective inhibitors of β-glycosidases

Ichikawa, Y., Igarashi, Y., Ichikawa, M. & Suhara, Y., 1998 Apr 8, In : Journal of the American Chemical Society. 120, 13, p. 3007-3018 12 p.

Research output: Contribution to journalArticle

213 Citations (Scopus)

1-N-Iminosugars: Potent and Selective Inhibitors of beta -Glycosidases

ICHIKAWA, ICHIKAWA., Y., Y., IGARASHI, IGARASHI., M., M. & SUHARA, SUHARA., 1998 Mar 1, In : Journal of American Chmeical Society. 120, p. 3007-3018

Research output: Contribution to journalArticle

213 Citations (Scopus)

Development of a Stereoselective C-glycosylation and Glycamino Acid-Based New Carbohydrate Analog

Suhara, Y., Igarashi, Y., Ichikawa, M., Izumi, M. & Ichikawa, Y., 1998 Jan 1, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 56, 7, p. 557-566 10 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Erratum: 1-N-Iminosugars: Potent and selective inhibitors of β- glycosidases (Journal of American Chemical Society (1998) 120 (3007-3018))

Ichikawa, Y., Igarashi, Y., Ichikawa, M. & Suhara, Y., 1998 Jun 17, In : Journal of the American Chemical Society. 120, 23, 1 p.

Research output: Contribution to journalComment/debate

Open Access
14 Citations (Scopus)
1999

Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor: Structure-activity relationship of 2-arachidonoylglycerol, ether- linked analogues, and related compounds

Sugiura, T., Kodaka, T., Nakane, S., Miyashita, T., Kondo, S., Suhara, Y., Takayama, H., Waku, K., Seki, C., Baba, N. & Ishima, Y., 1999 Jan 29, In : Journal of Biological Chemistry. 274, 5, p. 2794-2801 8 p.

Research output: Contribution to journalArticle

256 Citations (Scopus)

Evidence that the Cannabinoid CB1 Receptor Is a 2-Arachidonoylglycerol Receptor

SUGIURA, SUGIURA., T., T., KODAKA, KODAKA., NAKANE, NAKANE., S.:MIYASHITA, S. MIYASHITA., KONDO, KONDO., S., S., SUHARA, SUHARA., Y., Y., TAKAYAMA, TAKAYAMA., H., H., WAKU, WAKU., K., K., SEKI, SEKI., C., C., BABA, BABA., N., N. & Y., ISHIMA., 1999 Jan 1, In : Journal of Biological Chemistry. 274, p. 2794-2801

Research output: Contribution to journalArticle

256 Citations (Scopus)
2000

A Concise and Efficient Route to 2 alfa-( omega-Hydroxyalkoxy)-1alpha ,25-dihydroxyvitamin D3: Remarkably High Affinity to Vitamin D Receptor

KITTAKA, KITTAKA., A., A., SUHARA, SUHARA., Y., Y., TAKAYANAGI, TAKAYANAGI., H., H., FUJISHIMA, FUJISHIMA., T., T. & TAKAYAMA, TAKAYAMA., 2000 Aug 1, In : Organic Letters. 2, p. 2619-2622

Research output: Contribution to journalArticle

80 Citations (Scopus)

A concise and efficient route to 2α-(ω-hydroxyalkoxy)-1α,25-dihydroxyvitamin D3: Remarkably high affinity to vitamin D receptor

Kittaka, A., Suhara, Y., Takayanagi, H., Fujishima, T., Kurihara, M. & Takayama, H., 2000 Aug 24, In : Organic Letters. 2, 17, p. 2619-2622 4 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Efficient Synthesis and Biological Evaluation of Novel 2α-Substituted 1α,25-Dihydroxy- vitamin D3 Analogues: Remarkable Potency for Calcium-Regulating Effect

SUHARA, SUHARA., Y., Y., NIHEI, NIHEI., K., K., TANIGAWA, TANIGAWA., H., H., FUJISHIMA, FUJISHIMA., T., T., KONNO, KONNO., NAKAGAWA, NAKAGAWA., OKANO, OKANO., KURIHARA, KURIHARA., M., M. & TAKAYAMA, TAKAYAMA., 2000 Sep 1, In : Proceeding of the 10th Vitamin D Workshop.

Research output: Contribution to journalArticle

Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells

Sugiura, T., Kondo, S., Kishimoto, S., Miyashita, T., Nakane, S., Kodaka, T., Suhara, Y., Takayama, H. & Waku, K., 2000 Jan 7, In : Journal of Biological Chemistry. 275, 1, p. 605-612 8 p.

Research output: Contribution to journalArticle

305 Citations (Scopus)

Evidence that 2-Arachidonoylglycerol but Not N-Palmitoylethanolamine or Anandamide Is the Physiological Ligand for the Cannnabinoid CB2 Receptor

SUGIURA, SUGIURA., T., T., KONDO, KONDO., S., S., KISHIMOTO, KISHIMOTO., MIYASHITA, MIYASHITA., NAKANE, NAKANE., KODAKA, KODAKA., SUHARA, SUHARA., Y., Y., TAKAYAMA, TAKAYAMA., H., H., WAKU, WAKU. & K., K., 2000 Jan 1, In : Journal of Biological Chemistry. 275, p. 605-612

Research output: Contribution to journalArticle

305 Citations (Scopus)

Facile Synthesis of 2 -(Hydroxyalkoxy)-1 ,25-dihydroxyvitamin D

KITTAKA, KITTAKA., A., A., SUHARA, SUHARA., Y., Y., H., TAKAYANAGI., FUJISHIMA, FUJISHIMA., T., T., KURIHARA, KURIHARA., M., M., TAKAYAMA, TAKAYAMA. & H., H., 2000 Sep 1, In : Proceeding of the 10th Vitamin D Workshop.

Research output: Contribution to journalArticle

Syntheses and biological evaluation of novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues

Suhara, Y., Nihei, K. I., Tanigawa, H., Fujishima, T., Konno, K., Nakagawa, K., Okano, T. & Takayama, H., 2000 May 15, In : Bioorganic and Medicinal Chemistry Letters. 10, 10, p. 1129-1132 4 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Synthesis and Biological Activities of 2-Arachidonoylglycerol, an Endogenous Cannabinoid Receptor Ligand, and Its Metabolically Stable Ether-linked Analogues

SUHARA, SUHARA., Y., Y., TAKAYAMA, TAKAYAMA., H., H., NAKANE, NAKANE., S.:MIYASHITA, S. MIYASHITA., T., T., WAKU, WAKU., K., K. & SUGIURA, SUGIURA., 2000 Jun 1, In : Chemical & Pharmaceutical Bulletin. 48, p. 903-907

Research output: Contribution to journalArticle

34 Citations (Scopus)

Synthesis and biological activities of 2- arachidonoylglycerol, an endogenous cannabinoid receptor ligand, and its metabolically stable ether-linked analogues

Suhara, Y., Takayama, H., Nakane, S., Miyashita, T., Waku, K. & Sugiura, T., 2000 Jul, In : Chemical and Pharmaceutical Bulletin. 48, 7, p. 903-907 5 p.

Research output: Contribution to journalArticle

Open Access
34 Citations (Scopus)

Synthesis and Biological Evaluation of Novel 2 alfa-Substituted 1alpa,25-Dihydroxyvitamin D3 Analogues

SUHARA, SUHARA., Y., Y., NIHEI, NIHEI., K., K., TANIGAWA, TANIGAWA., H., H., FUJISHIMA, FUJISHIMA., T., T., KONNO, KONNO., NAKAGAWA, NAKAGAWA., OKANO, OKANO. & TAKAYAMA, TAKAYAMA., 2000 Jun 1, In : Bioorganic & Medicinal Chemistry Letters. 10, p. 1129-1132

Research output: Contribution to journalArticle

64 Citations (Scopus)
2001

Efficient and Versatile Synthesis of Novel 2alpha -Substituted 1alpha ,25-Dihydroxyvitamin D3 Analogues and Their Docking to Vitamin D Receptors

SUHARA, SUHARA., Y, Y., NIHEI, NIHEI., K., K., KURIHARA, KURIHARA., M., M., KITTAKA, KITTAKA., A., A., YAMAGUCHI, YAMAGUCHI., FUJISHIMA, FUJISHIMA., T., T., KONNO, KONNO., MIYATA, MIYATA., N., N., TAKAYAMA, TAKAYAMA. & H., H., 2001 Nov 1, In : Journal of Organic Chemistry. 66, p. 8760-8771

Research output: Contribution to journalArticle

94 Citations (Scopus)

Efficient and versatile synthesis of novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues and their docking to vitamin D receptors

Suhara, Y., Nihei, K. I., Kurihara, M., Kittaka, A., Yamaguchi, K., Fujishima, T., Konno, K., Miyata, N. & Takayama, H., 2001 Dec 28, In : Journal of Organic Chemistry. 66, 26, p. 8760-8771 12 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand

Suhara, Y., Nakane, S., Arai, S., Takayama, H., Waku, K., Ishima, Y. & Sugiura, T., 2001 Aug 6, In : Bioorganic and Medicinal Chemistry Letters. 11, 15, p. 1985-1988 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2002

Design and Efficient Syntheses of New Stable 1 alpha,25-Dihydroxyvitamin D3 Analogues Containing Amide-bond

SUHARA, SUHARA., Y, Y., KITTAKA, KITTAKA., A., A., ONO, ONO., K., K., FUJISHIMA, FUJISHIMA., T., T., YOSHIDA, YOSHIDA., TAKAYAMA, TAKAYAMA. & H., H., 2002 Dec 1, In : Bioorganic & Medicinal Chemistry Letters. 12, p. 3533-3536

Research output: Contribution to journalArticle

17 Citations (Scopus)

Design and efficient synthesis of new stable 1α,25-dihydroxy-19-norvitamin D3 analogues containing amide bond

Suhara, Y., Kittaka, A., Ono, K., Kurihara, M., Fujishima, T., Yoshida, A. & Takayama, H., 2002 Dec 1, In : Bioorganic and Medicinal Chemistry Letters. 12, 24, p. 3533-3536 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Oligomers of glycamino acid

Suhara, Y., Yamaguchi, Y., Collins, B., Schnaar, R. L., Yanagishita, M., Hildreth, J. E. K., Shimada, I. & Ichikawa, Y., 2002 Apr 18, In : Bioorganic and Medicinal Chemistry. 10, 6, p. 1999-2013 15 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Synthesis and biological activity of the A-ring modified 1α, 25-dihydroxyvitamin D3

Takayama, H., Kittaka, A., Fujishima, T. & Suhara, Y., 2002 Apr, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 60, 4, p. 370-382 13 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Synthesis and Testing of 2 alpha-Modified 1 alpha,25-Dihydroxyvitamin D3 Analogues with a Double Side Chain: Marked Cell Differenciation Activity

SUHARA, SUHARA., Y, Y., KITTAKA, KITTAKA., A., A., KISHIMOTO, KISHIMOTO., S., S., CALVERLEY, CALVERLEY., M., J., FUJISHIMA, FUJISHIMA., T., T., SAITO, SAITO., N., N., SUGIURA, SUGIURA., WAKU, WAKU., K., K., TAKAYAMA, TAKAYAMA. & H., H., 2002 Dec 1, In : Bioorganic & Medicinal Chemistry Letters. 12, p. 3255-3258

Research output: Contribution to journalArticle

26 Citations (Scopus)

Synthesis and testing of 2α-Modified 1α,25-Dihydroxyvitamin D3 analogues with a double side chain: Marked cell differentiation activity

Suhara, Y., Kittaka, A., Kishimoto, S., Calverley, M. J., Fujishima, T., Saito, N., Sugiura, T., Waku, K. & Takayama, H., 2002 Nov 18, In : Bioorganic and Medicinal Chemistry Letters. 12, 22, p. 3255-3258 4 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2003

2alpha -(3-Hydroxypropyl)- and 2 alpha-(3-Hydroxypropyl)-1alpha ,25-dihydroxyvitamin D3 accessible to Vitamin D Receptor Mutant Related to Hereditary Vitamin D-Resistant Rickets

KITTAKA, KITTAKA., A., A., KURIHARA, KURIHARA., M., M., PLEG, PLEG., S., S., SUHARA, SUHARA., Y., Y., TAKAYAMA, TAKAYAMA. & H., H., 2003 Mar 1, In : Chemical & Pharmaceutical Bulletin. 51, p. 357-358

Research output: Contribution to journalArticle

28 Citations (Scopus)

2 α-(3-hydroxypropyl)- and 2 α-(3-hydroxypropoxy)-1 α,25-dihydroxyvitamin D3 accessible to vitamin D receptor mutant related to hereditary vitamin D-resistant rickets

Kittaka, A., Kurihara, M., Peleg, S., Suhara, Y. & Takayama, H., 2003 Mar, In : Chemical and Pharmaceutical Bulletin. 51, 3, p. 357-358 2 p.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)

Concise Synthesis and Biological Activities of 2alpha-Alkyl- and 2 alpha-( omega-Hydroxyalkyl)-20-epi-1 alpha,25-dihydroxyvitamin D3

HONZAWA, HONZAWA., S., S., SUHARA, SUHARA., Y., Y., NIHEI, NIHEI., K., K., SAITO, SAITO., N., N., KISHIMOTO, KISHIMOTO., FUJISHIMA, FUJISHIMA., T., T., KURIHARA, KURIHARA., M.:SUGIURA, M. SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA., H., H. & A., KITTAKA., 2003 Oct 1, In : Bioorganic & Medicinal Chemistry. 13, p. 3503-3506

Research output: Contribution to journalArticle

24 Citations (Scopus)

Concise synthesis and biological activities of 2α-alkyl- and 2α-(ω-hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D 3

Honzawa, S., Suhara, Y., Nihei, K. I., Saito, N., Kishimoto, S., Fujishima, T., Kurihara, M., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2003 Oct 20, In : Bioorganic and Medicinal Chemistry Letters. 13, 20, p. 3503-3506 4 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Design, synthesis, and biological studies of the A-ring-modified 1,25-dihydroxyvitamin D3 analogs

TAKAYAMA, TAKAYAMA., H., H., KITTAKA, KITTAKA., A., A., FUJISHIMA, FUJISHIMA., T., T., SUHARA, SUHARA. & Y., Y., 2003 May 1, In : Recent Results in Cancer Research164 (Vitamin D Analogs in Cancer Prevention and Therapy). 164, p. 289-317

Research output: Contribution to journalArticle

25 Citations (Scopus)
25 Citations (Scopus)

Efficient and Convergent Coupling Route for the Short-step Synthesis of Enantiopure 2alpha - and 2beta -Alkylated 1alpha ,25-Dihydroxy-19-norvitamin D3 Analogues

YOSHIDA, YOSHIDA., A., A., ONO, ONO., K., K., SUHARA, SUHARA., Y., Y., SAITO, SAITO., N., N., TAKAYAMA, TAKAYAMA., H., H. & KITTAKA, KITTAKA., 2003 Jun 1, In : Synlett. 8, p. 1175-1179

Research output: Contribution to journalArticle

Efficient and convergent coupling route for the short-step synthesis of enantiopure 2α- and 2β-alkylated 1α,25-dihydroxy-19-norvitamin D3 analogues

Yoshida, A., Ono, K., Suhara, Y., Saito, N., Takayama, H. & Kittaka, A., 2003 Jan 1, In : Synlett. 8, p. 1175-1179 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Efficient Synthesis of 2-Modified 1 alpha,25-Dihydroxy-19-norvitamin D3 with Julia Olefination: High Potency in Induction of Differentiation on HL-60 Cells

ONO, ONO., K., K., YOSHIDA, YOSHIDA., A., A., SAITO, SAITO., N., N., FUJISHIMA, FUJISHIMA., T., T., HONZAWA, HONZAWA., S., S., SUHARA, SUHARA., Y., Y., KISHIMOTO, KISHIMOTO., SUGIURA, SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA. & A., H. KITTAKA., 2003 Aug 1, In : Journal of Organic Chemistry. 68, p. 7407-7415

Research output: Contribution to journalArticle

98 Citations (Scopus)

Efficient synthesis of 2-modified 1α,25-dihydroxy-19-norvitamin D3 with Julia olefination: High potency in induction of differentiation on HL-60 cells

Ono, K., Yoshida, A., Saito, N., Fujishima, T., Honzawa, S., Suhara, Y., Kishimoto, S., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2003 Sep 19, In : Journal of Organic Chemistry. 68, 19, p. 7407-7415 9 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)