• 5581 Citations
  • 40 h-Index
1994 …2020

Research output per year

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Research Output

  • 5581 Citations
  • 40 h-Index
  • 123 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Short survey

1-N-Iminosugars: Potent and selective inhibitors of β-glycosidases

Ichikawa, Y., Igarashi, Y., Ichikawa, M. & Suhara, Y., 1998 Apr 8, In : Journal of the American Chemical Society. 120, 13, p. 3007-3018 12 p.

Research output: Contribution to journalArticle

213 Citations (Scopus)

1-N-Iminosugars: Potent and Selective Inhibitors of beta -Glycosidases

ICHIKAWA, ICHIKAWA., Y., Y., IGARASHI, IGARASHI., M., M. & SUHARA, SUHARA., 1998 Mar 1, In : Journal of American Chmeical Society. 120, p. 3007-3018

Research output: Contribution to journalArticle

213 Citations (Scopus)

2alpha -(3-Hydroxypropyl)- and 2 alpha-(3-Hydroxypropyl)-1alpha ,25-dihydroxyvitamin D3 accessible to Vitamin D Receptor Mutant Related to Hereditary Vitamin D-Resistant Rickets

KITTAKA, KITTAKA., A., A., KURIHARA, KURIHARA., M., M., PLEG, PLEG., S., S., SUHARA, SUHARA., Y., Y., TAKAYAMA, TAKAYAMA. & H., H., 2003 Mar 1, In : Chemical & Pharmaceutical Bulletin. 51, p. 357-358

Research output: Contribution to journalArticle

28 Citations (Scopus)

2 α-(3-hydroxypropyl)- and 2 α-(3-hydroxypropoxy)-1 α,25-dihydroxyvitamin D3 accessible to vitamin D receptor mutant related to hereditary vitamin D-resistant rickets

Kittaka, A., Kurihara, M., Peleg, S., Suhara, Y. & Takayama, H., 2003 Mar, In : Chemical and Pharmaceutical Bulletin. 51, 3, p. 357-358 2 p.

Research output: Contribution to journalArticle

Open Access
28 Citations (Scopus)

A Concise and Efficient Route to 2 alfa-( omega-Hydroxyalkoxy)-1alpha ,25-dihydroxyvitamin D3: Remarkably High Affinity to Vitamin D Receptor

KITTAKA, KITTAKA., A., A., SUHARA, SUHARA., Y., Y., TAKAYANAGI, TAKAYANAGI., H., H., FUJISHIMA, FUJISHIMA., T., T. & TAKAYAMA, TAKAYAMA., 2000 Aug 1, In : Organic Letters. 2, p. 2619-2622

Research output: Contribution to journalArticle

80 Citations (Scopus)

A concise and efficient route to 2α-(ω-hydroxyalkoxy)-1α,25-dihydroxyvitamin D3: Remarkably high affinity to vitamin D receptor

Kittaka, A., Suhara, Y., Takayanagi, H., Fujishima, T., Kurihara, M. & Takayama, H., 2000 Aug 24, In : Organic Letters. 2, 17, p. 2619-2622 4 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

A single oral administration of theaflavins increases energy expenditure and the expression of metabolic genes

Kudo, N., Arai, Y., Suhara, Y., Ishii, T., Nakayama, T. & Osakabe, N., 2015 Sep 16, In : PLoS ONE. 10, 9, e0137809.

Research output: Contribution to journalArticle

19 Citations (Scopus)

A single oral dose of flavan-3-ols enhances energy expenditure by sympathetic nerve stimulation in mice

Kamio, N., Suzuki, T., Watanabe, Y., Suhara, Y. & Osakabe, N., 2016 Feb 1, In : Free Radical Biology and Medicine. 91, p. 256-263 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Biological Activities of 2 -Substituted Analogues of 1 ,25-Dihydroxyvitamin D3 in Human Promyelocytic Leukemia (HL-60) Cell Proliferation and Differentiation

TAKAHASHI, TAKAHASHI., E, E., E., E., NAKAGAWA, NAKAGAWA., K., K., SUHARA, SUHARA., Y., Y., KITTAKA, KITTAKA., A., A., NIHEI, NIHEI., KONNO, KONNO., TAKAYAMA, TAKAYAMA., H., H., OKANO, OKANO. & T., T., 2006 Nov 1, In : Biological & Pharmaceutical Bulletin. 29, p. 2246-2250

Research output: Contribution to journalArticle

22 Citations (Scopus)

Biological activities of 2α-substituted analogues of 1α,25-dihydroxyvitamin D3 in transcriptional regulation and human promyelocytic leukemia (HL-60) cell proliferation and differentiation

Takahashi, E., Nakagawa, K., Suhara, Y., Kittaka, A., Nihei, K. I., Konno, K., Takayama, H., Ozono, K. & Okano, T., 2006 Nov, In : Biological and Pharmaceutical Bulletin. 29, 11, p. 2246-2250 5 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Comparative uptake, metabolism, and utilization of menaquinone-4 and phylloquinone in human cultured cell lines

Suhara, Y., Murakami, A., Nakagawa, K., Mizuguchi, Y. & Okano, T., 2006 Oct 1, In : Bioorganic and Medicinal Chemistry. 14, 19, p. 6601-6607 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Comparative Uptake, Metabolism and Utilization of Menaquinone-4 and Phylloquinone in Human Cultured Cell Lines

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., NAKAGAWA, NAKAGAWA., K., K., MIZUGUCHI, MIZUGUCHI., OKANO, OKANO. & T., T., 2006 Aug 1, In : Bioorganic & Medicinal Chemistry. 14, p. 6601-6607

Research output: Contribution to journalArticle

17 Citations (Scopus)

Comparison of the biological activity of synthetic N-acylated asparagine or serine linked monosaccharide lipid A analogs

Shimizu, T., Iwamoto, Y., Yanagihara, Y., Ryoyama, K., Suhara, Y., Ikeda, K. & Achiwa, K., 1996 Jan 1, In : Immunobiology. 196, 4, p. 321-331 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Comparison of the Biological Activity of Synthetic N-Acylated Asparagine or Serine Linked Monosaccharide Lipid A Analogues

SHIMIZU, SHIMIZU., T., T., IWAMOTO, IWAMOTO., Y., Y., YANAGIHARA, YANAGIHARA., RYOYAMA, RYOYAMA., K., K., SUHARA, SUHARA., IKEDA, IKEDA. & ACHIWA, ACHIWA., 1996 Mar 1, In : Immunobiology. 196, p. 321-331

Research output: Contribution to journalArticle

Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice

Nakagawa, Y., Ishimura, K., Oya, S., Kamino, M., Fujii, Y., Nanba, F., Toda, T., Ishii, T., Adachi, T., Suhara, Y. & Osakabe, N., 2018 Jul, In : PLoS ONE. 13, 7, e0201203.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Concise Synthesis and Biological Activities of 2alpha-Alkyl- and 2 alpha-( omega-Hydroxyalkyl)-20-epi-1 alpha,25-dihydroxyvitamin D3

HONZAWA, HONZAWA., S., S., SUHARA, SUHARA., Y., Y., NIHEI, NIHEI., K., K., SAITO, SAITO., N., N., KISHIMOTO, KISHIMOTO., FUJISHIMA, FUJISHIMA., T., T., KURIHARA, KURIHARA., M.:SUGIURA, M. SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA., H., H. & A., KITTAKA., 2003 Oct 1, In : Bioorganic & Medicinal Chemistry. 13, p. 3503-3506

Research output: Contribution to journalArticle

24 Citations (Scopus)

Concise synthesis and biological activities of 2α-alkyl- and 2α-(ω-hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D 3

Honzawa, S., Suhara, Y., Nihei, K. I., Saito, N., Kishimoto, S., Fujishima, T., Kurihara, M., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2003 Oct 20, In : Bioorganic and Medicinal Chemistry Letters. 13, 20, p. 3503-3506 4 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Conversion of phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) in mice: Two possible routes for menaquinone-4 accumulation in cerebra of mice

Okano, T., Shimomura, Y., Yamane, M., Suhara, Y., Kamao, M., Sugiura, M. & Nakagawa, K., 2008 Apr 25, In : Journal of Biological Chemistry. 283, 17, p. 11270-11279 10 p.

Research output: Contribution to journalArticle

163 Citations (Scopus)

Conversion of Phylloquinone (Vitamin K1) into Menaquinone-4 (Vitamin K2) in Mice: TWO POSSIBLE ROUTE FOR MENAQUINONE-4 ACCUMULATION IN CEREBRA OF MICE

OKANO, OKANO., T, T., T., T., SHIMOMURA, SHIMOMURA., Y., Y., YAMANE, YAMANE., M., M., SUHARA, SUHARA., KAMAO, KAMAO., SUGIURA, SUGIURA., NAKAGAWA, NAKAGAWA. & K., K., 2008 Nov 1, In : Journal of Biological Chemistry. 283, p. 11270-11279

Research output: Contribution to journalArticle

163 Citations (Scopus)

Conversion of Vitamin K Analogues to Menaquinone-4 in Osteoblastic Cells

SUHARA, SUHARA., Y, Y., Y., Y., KAMAO, KAMAO., M., M., NAKAGAWA, NAKAGAWA., K., K., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2008 Sep 1, In : Proceedings of 30th Annual Meeting of the American Society for Bone and Mineral Research.

Research output: Contribution to journalArticle

Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11

Edson, K. Z., Prasad, B., Unadkat, J. D., Suhara, Y., Okano, T., Peter Guengerich, F. & Rettie, A. E., 2013 Nov 19, In : Biochemistry. 52, 46, p. 8276-8285 10 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Design, synthesis, and biological studies of the A-ring-modified 1,25-dihydroxyvitamin D3 analogs

TAKAYAMA, TAKAYAMA., H., H., KITTAKA, KITTAKA., A., A., FUJISHIMA, FUJISHIMA., T., T., SUHARA, SUHARA. & Y., Y., 2003 May 1, In : Recent Results in Cancer Research164 (Vitamin D Analogs in Cancer Prevention and Therapy). 164, p. 289-317

Research output: Contribution to journalArticle

25 Citations (Scopus)
25 Citations (Scopus)

Design and Efficient Syntheses of New Stable 1 alpha,25-Dihydroxyvitamin D3 Analogues Containing Amide-bond

SUHARA, SUHARA., Y, Y., KITTAKA, KITTAKA., A., A., ONO, ONO., K., K., FUJISHIMA, FUJISHIMA., T., T., YOSHIDA, YOSHIDA., TAKAYAMA, TAKAYAMA. & H., H., 2002 Dec 1, In : Bioorganic & Medicinal Chemistry Letters. 12, p. 3533-3536

Research output: Contribution to journalArticle

17 Citations (Scopus)

Design and Efficient Synthesis of 2alpha-(omega-Hydroxyalkoxy)-1alpha,25-dihydroxyvitamin D3 Analogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity

SAITO, SAITO., N., N., SUHARA, SUHARA., Y., Y., KURIHARA, KURIHARA., M., M., FUJISHIMA, FUJISHIMA., T., T., HONZAWA, HONZAWA., S., S., TAKAYANAGI, TAKAYANAGI., H., H., KOZONO, KOZONO., MATSUMOTO, MATSUMOTO., OHMORI, OHMORI., MIYATA, MIYATA. & A., N. TAKAYAMA. H. KITTAKA., 2004 Sep 1, In : Journal of Organic Chemistry. 69, p. 7463-7471

Research output: Contribution to journalArticle

69 Citations (Scopus)

Design and efficient synthesis of 2α-(ω-hydroxyalkoxy)- 1α,25-dihydroxyvitamin D3 analogues, including 2-epi-ED-71 and their 20-epimers with HL-60 cell differentiation activity

Saito, N., Suhara, Y., Kurihara, M., Fujishima, T., Honzawa, S., Takayanagi, H., Kozono, T., Matsumoto, M., Ohmori, M., Miyata, N., Takayama, H. & Kittaka, A., 2004 Oct 29, In : Journal of Organic Chemistry. 69, 22, p. 7463-7471 9 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Design and efficient synthesis of new stable 1α,25-dihydroxy-19-norvitamin D3 analogues containing amide bond

Suhara, Y., Kittaka, A., Ono, K., Kurihara, M., Fujishima, T., Yoshida, A. & Takayama, H., 2002 Dec 1, In : Bioorganic and Medicinal Chemistry Letters. 12, 24, p. 3533-3536 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Design and synthesis of biologically active analogues of vitamin K2: Evaluation of their biological activities with cultured human cell lines

Suhara, Y., Hirota, Y., Nakagawa, K., Kamao, M., Tsugawa, N. & Okano, T., 2008 Mar 15, In : Bioorganic and Medicinal Chemistry. 16, 6, p. 3108-3117 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Design and Synthesis of Biologically Active Analogues of Vitamin K2: Evaluation of their Biological Activities with Cultured Human Cell Lines

SUHARA, SUHARA., Y, Y., Y., Y., HIROTA, HIROTA., NAKAGAWA, NAKAGAWA., K., K., KAMAO, KAMAO., M., M., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2008 Jan 1, In : Bioorganic & Medicinal Chemistry. 16, p. 3108-3117

Research output: Contribution to journalArticle

13 Citations (Scopus)

Determination of 25-hydroxyvitamin D in human plasma using high-performance liquid chromatography-tandem mass spectrometry

Tsugawa, N., Suhara, Y., Kamao, M. & Okano, T., 2005 May 1, In : Analytical Chemistry. 77, 9, p. 3001-3007 7 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Determination of 25-Hydroxyvitamin D in Human Plasma Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry.

TSUGAWA, TSUGAWA., N., N., SUHARA, SUHARA., Y., Y., KAMAO, KAMAO., M., M., OKANO, OKANO. & T., T., 2005 May 1, In : Analytical Chemistry. 77, p. 3001-3007

Research output: Contribution to journalArticle

102 Citations (Scopus)
11 Citations (Scopus)

Determination of Fat-Soluble Vitamins in Human Plasma, Breast Milk and Food Samples: Application in Nutrition Survey for Establishment of "Dietary Reference Intakes for Japanese"

KAMAO, KAMAO., M, M., M., M., TSUGAWA, TSUGAWA., N., N., SUHARA, SUHARA., Y., Y., OKANO, OKANO. & T., T., 2007 Mar 1, In : Journal of Health Science. 53, p. 257-262

Research output: Contribution to journalArticle

11 Citations (Scopus)

Determination of menadione by liquid chromatography-tandem mass spectrometry using pseudo multiple reaction monitoring

Kamao, M., Hirota, Y., Suhara, Y., Tsugawa, N., Nakagawa, K., Okano, T. & Hasegawa, H., 2017, In : Analytical Sciences. 33, 7, p. 863-867 5 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)
54 Citations (Scopus)
54 Citations (Scopus)

Development of a Biologically Active Fluorescent-labeled Vitamin K and Monitoring of the Subcellular Distribution in Cells

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., SHIMOMURA, SHIMOMURA., NAKAGAWA, NAKAGAWA., K., K., OKANO, OKANO. & T., T., 2006 Sep 1, In : Proceedings of 28th Annual Meeting of the American Society for Bone and Mineral Research.

Research output: Contribution to journalArticle

Development of a Stereoselective C-glycosylation and Glycamino Acid-Based New Carbohydrate Analog

Suhara, Y., Igarashi, Y., Ichikawa, M., Izumi, M. & Ichikawa, Y., 1998 Jan 1, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 56, 7, p. 557-566 10 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
10 Citations (Scopus)

Efficient and Convergent Coupling Route for the Short-step Synthesis of Enantiopure 2alpha - and 2beta -Alkylated 1alpha ,25-Dihydroxy-19-norvitamin D3 Analogues

YOSHIDA, YOSHIDA., A., A., ONO, ONO., K., K., SUHARA, SUHARA., Y., Y., SAITO, SAITO., N., N., TAKAYAMA, TAKAYAMA., H., H. & KITTAKA, KITTAKA., 2003 Jun 1, In : Synlett. 8, p. 1175-1179

Research output: Contribution to journalArticle

Efficient and convergent coupling route for the short-step synthesis of enantiopure 2α- and 2β-alkylated 1α,25-dihydroxy-19-norvitamin D3 analogues

Yoshida, A., Ono, K., Suhara, Y., Saito, N., Takayama, H. & Kittaka, A., 2003 Jan 1, In : Synlett. 8, p. 1175-1179 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Efficient and Versatile Synthesis of Novel 2alpha -Substituted 1alpha ,25-Dihydroxyvitamin D3 Analogues and Their Docking to Vitamin D Receptors

SUHARA, SUHARA., Y, Y., NIHEI, NIHEI., K., K., KURIHARA, KURIHARA., M., M., KITTAKA, KITTAKA., A., A., YAMAGUCHI, YAMAGUCHI., FUJISHIMA, FUJISHIMA., T., T., KONNO, KONNO., MIYATA, MIYATA., N., N., TAKAYAMA, TAKAYAMA. & H., H., 2001 Nov 1, In : Journal of Organic Chemistry. 66, p. 8760-8771

Research output: Contribution to journalArticle

94 Citations (Scopus)

Efficient and versatile synthesis of novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues and their docking to vitamin D receptors

Suhara, Y., Nihei, K. I., Kurihara, M., Kittaka, A., Yamaguchi, K., Fujishima, T., Konno, K., Miyata, N. & Takayama, H., 2001 Dec 28, In : Journal of Organic Chemistry. 66, 26, p. 8760-8771 12 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Efficient synthesis and biological evaluation of demethyl geranylgeranoic acid derivatives

Wada, A., Wang, F., Suhara, Y., Yamano, Y., Okitsu, T., Nakagawa, K. & Okano, T., 2010 Aug 15, In : Bioorganic and Medicinal Chemistry. 18, 16, p. 5795-5806 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Efficient Synthesis and Biological Evaluation of Novel 2α-Substituted 1α,25-Dihydroxy- vitamin D3 Analogues: Remarkable Potency for Calcium-Regulating Effect

SUHARA, SUHARA., Y., Y., NIHEI, NIHEI., K., K., TANIGAWA, TANIGAWA., H., H., FUJISHIMA, FUJISHIMA., T., T., KONNO, KONNO., NAKAGAWA, NAKAGAWA., OKANO, OKANO., KURIHARA, KURIHARA., M., M. & TAKAYAMA, TAKAYAMA., 2000 Sep 1, In : Proceeding of the 10th Vitamin D Workshop.

Research output: Contribution to journalArticle