• 5407 Citations
  • 40 h-Index
19942019

Research output per year

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Research Output

  • 5407 Citations
  • 40 h-Index
  • 127 Article
  • 1 Comment/debate
  • 1 Review article
2007

Vitamin K content of foods and dietary vitamin K intake in Japanese young women

Kamao, M., Suhara, Y., Tsugawa, N., Uwano, M., Yamaguchi, N., Uenishi, K., Ishida, H., Sasaki, S. & Okano, T., 2007 Dec, In : Journal of Nutritional Science and Vitaminology. 53, 6, p. 464-470 7 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
2006

Biological Activities of 2 -Substituted Analogues of 1 ,25-Dihydroxyvitamin D3 in Human Promyelocytic Leukemia (HL-60) Cell Proliferation and Differentiation

TAKAHASHI, TAKAHASHI., E, E., E., E., NAKAGAWA, NAKAGAWA., K., K., SUHARA, SUHARA., Y., Y., KITTAKA, KITTAKA., A., A., NIHEI, NIHEI., KONNO, KONNO., TAKAYAMA, TAKAYAMA., H., H., OKANO, OKANO. & T., T., 2006 Nov 1, In : Biological & Pharmaceutical Bulletin. 29, p. 2246-2250

Research output: Contribution to journalArticle

21 Citations (Scopus)

Biological activities of 2α-substituted analogues of 1α,25-dihydroxyvitamin D3 in transcriptional regulation and human promyelocytic leukemia (HL-60) cell proliferation and differentiation

Takahashi, E., Nakagawa, K., Suhara, Y., Kittaka, A., Nihei, K. I., Konno, K., Takayama, H., Ozono, K. & Okano, T., 2006 Nov, In : Biological and Pharmaceutical Bulletin. 29, 11, p. 2246-2250 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Comparative uptake, metabolism, and utilization of menaquinone-4 and phylloquinone in human cultured cell lines

Suhara, Y., Murakami, A., Nakagawa, K., Mizuguchi, Y. & Okano, T., 2006 Oct 1, In : Bioorganic and Medicinal Chemistry. 14, 19, p. 6601-6607 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Comparative Uptake, Metabolism and Utilization of Menaquinone-4 and Phylloquinone in Human Cultured Cell Lines

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., NAKAGAWA, NAKAGAWA., K., K., MIZUGUCHI, MIZUGUCHI., OKANO, OKANO. & T., T., 2006 Aug 1, In : Bioorganic & Medicinal Chemistry. 14, p. 6601-6607

Research output: Contribution to journalArticle

17 Citations (Scopus)

Development of a Biologically Active Fluorescent-labeled Vitamin K and Monitoring of the Subcellular Distribution in Cells

SUHARA, SUHARA., Y, Y., Y., Y., MURAKAMI, MURAKAMI., A., A., SHIMOMURA, SHIMOMURA., NAKAGAWA, NAKAGAWA., K., K., OKANO, OKANO. & T., T., 2006 Sep 1, In : Proceedings of 28th Annual Meeting of the American Society for Bone and Mineral Research.

Research output: Contribution to journalArticle

Efficient synthesis of carbopeptoid oligomers: insight into mimicry of β-peptide

Suhara, Y., Kurihara, M., Kittaka, A. & Ichikawa, Y., 2006 Aug 21, In : Tetrahedron. 62, 34, p. 8207-8217 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Efficient Synthesis of Carbopeptoid Oligomers: Insight into Mimicry of -Peptide

SUHARA, SUHARA., Y., Y., KURIHARA, KURIHARA., M., M., KITTAKA, KITTAKA., A., A. & ICHIKAWA, ICHIKAWA., 2006 Aug 1, In : Tetrahedron. 62, p. 8207-8217

Research output: Contribution to journalArticle

13 Citations (Scopus)

Prevention of osteoporosis by foods and dietary supplements. Vitamin D and bone metabolism

Suhara, Y., 2006 Oct, In : Clinical calcium. 16, 10, p. 50-54 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Probing a Water Channel near the A-Ring of Receptor-Bound 1 ,25-Dihydroxyvitamin D3 with Selected 2 -Substituted Analogues

HOURAI, HOURAI., S, S., S., S., FUJISHIMA, FUJISHIMA., T., T., KITTAKA, KITTAKA., A., A., SUHARA, SUHARA., Y. 5, Y. ., TAKAYAMA, TAKAYAMA., H., H., ROCHEL, ROCHEL., N., N., MORAS, MORAS. & D., D., 2006 Jul 1, In : Journal of Medicinal Chemistry. 49, p. 5199-5205

Research output: Contribution to journalArticle

91 Citations (Scopus)

Probing a water channel near the A-ring of receptor-bound 1α,25-dihydroxyvitamin D3 with selected 2α-substituted analogues

Hourai, S., Fujishima, T., Kittaka, A., Suhara, Y., Takayama, H., Rochel, N. & Moras, D., 2006 Aug 24, In : Journal of Medicinal Chemistry. 49, 17, p. 5199-5205 7 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Vitamin K status of healthy Japanese women: Age-related vitamin K requirement for γ-carboxylation of osteocalcin

Tsugawa, N., Shiraki, M., Suhara, Y., Kamao, M., Tanaka, K. & Okano, T., 2006 Feb 1, In : American Journal of Clinical Nutrition. 83, 2, p. 380-386 7 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Vitamin K Status of Healthy Japanese Women; Age-related Vitamin K Requirement for gamma-Carboxylation of Osteocalcin

TSUGAWA, TSUGAWA., N., N., SHIRAKI, SHIRAKI., M., M., SUHARA, SUHARA., Y., Y., KAMAO, KAMAO., TANAKA, TANAKA., K., K., OKANO, OKANO. & T., T., 2006 Jan 1, In : The American Society for Nutrution. 83, p. 380-386

Research output: Contribution to journalArticle

82 Citations (Scopus)

Determination of 25-hydroxyvitamin D in human plasma using high-performance liquid chromatography-tandem mass spectrometry

Tsugawa, N., Suhara, Y., Kamao, M. & Okano, T., 2005 May 1, In : Analytical Chemistry. 77, 9, p. 3001-3007 7 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

Determination of 25-Hydroxyvitamin D in Human Plasma Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry.

TSUGAWA, TSUGAWA., N., N., SUHARA, SUHARA., Y., Y., KAMAO, KAMAO., M., M., OKANO, OKANO. & T., T., 2005 May 1, In : Analytical Chemistry. 77, p. 3001-3007

Research output: Contribution to journalArticle

98 Citations (Scopus)
54 Citations (Scopus)
54 Citations (Scopus)

Metabolism of 2 -Propoxy-1 ,25-dihydroxyvitamin D3 and 2 -(3-Hydroxypropoxy)-1 ,25 -dihydroxyvitamin D3 by Human CYP27A1 and CYP24A1.

ABE, ABE., D., D., SAKAKI, SAKAKI., T., T., KUSUDO, KUSUDO., KITTAKA, KITTAKA., A., A., SAITO, SAITO., N., N., SUHARA, SUHARA., Y., Y., FUJISHIMA, FUJISHIMA., TAKAYAMA, TAKAYAMA., H. HAMAMOTO, H. HAMAMOTO., H, H., KAMAKURA, KAMAKURA., M, M. & K., OHTA. M. INOUYE., 2005 Jun 1, In : Drug Metabolism and Disposition. 33, p. 778-784

Research output: Contribution to journalArticle

Metabolism of 2α-propoxy-1α,25-dihydroxyvitamin D3 and 2α-(3-hydroxypropoxy)-1α,25-dihydroxyvitamin D3 by human CYP27A1 and CYP24A1

Abe, D., Sakaki, T., Kusudo, T., Kittaka, A., Saito, N., Suhara, Y., Fujishima, T., Takayama, H., Hamamoto, H., Kamakura, M., Ohta, M. & Inouye, K., 2005 Jun, In : Drug Metabolism and Disposition. 33, 6, p. 778-784 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Method for the Detection of Vitamin K Homologues in Human Plasma Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry

SUHARA, SUHARA., Y., Y., KAMAO, KAMAO., M., M., TSUGAWA, TSUGAWA., N., N., OKANO, OKANO. & T., T., 2005 Feb 1, In : Analytical Chemistry. 77, p. 757-763

Research output: Contribution to journalArticle

82 Citations (Scopus)

Method for the determination of vitamin K homologues in human plasma using high-performance liquid chromatography-tandem mass spectrometry

Suhara, Y., Kamao, M., Tsugawa, N. & Okano, T., 2005 Feb 1, In : Analytical Chemistry. 77, 3, p. 757-763 7 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Vitamin K Circulating Levels and Associations with Bone Metabolism in Healthy Japanese Women

TSUGAWA, TSUGAWA., N., N., SHIRAKI, SHIRAKI., M., M., SUHARA, SUHARA., Y., Y., KAMAO, KAMAO., TANAKA, TANAKA., K., K., OKANO, OKANO. & T., T., 2005 Sep 1, In : Proceedings of 27th Annual Meeting of the American Society for Bone and Mineral Research.

Research output: Contribution to journalArticle

Design and Efficient Synthesis of 2alpha-(omega-Hydroxyalkoxy)-1alpha,25-dihydroxyvitamin D3 Analogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity

SAITO, SAITO., N., N., SUHARA, SUHARA., Y., Y., KURIHARA, KURIHARA., M., M., FUJISHIMA, FUJISHIMA., T., T., HONZAWA, HONZAWA., S., S., TAKAYANAGI, TAKAYANAGI., H., H., KOZONO, KOZONO., MATSUMOTO, MATSUMOTO., OHMORI, OHMORI., MIYATA, MIYATA. & A., N. TAKAYAMA. H. KITTAKA., 2004 Sep 1, In : Journal of Organic Chemistry. 69, p. 7463-7471

Research output: Contribution to journalArticle

68 Citations (Scopus)

Design and efficient synthesis of 2α-(ω-hydroxyalkoxy)- 1α,25-dihydroxyvitamin D3 analogues, including 2-epi-ED-71 and their 20-epimers with HL-60 cell differentiation activity

Saito, N., Suhara, Y., Kurihara, M., Fujishima, T., Honzawa, S., Takayanagi, H., Kozono, T., Matsumoto, M., Ohmori, M., Miyata, N., Takayama, H. & Kittaka, A., 2004 Oct 29, In : Journal of Organic Chemistry. 69, 22, p. 7463-7471 9 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Synthesis of Novel 1 ,25-Dihydroxy-19-norvitamin D3 with an Amide Conjugate

SUHARA, SUHARA., Y., Y., ONO, ONO., K., K., YOSHIDA, YOSHIDA., A., A., FUJISHIMA, FUJISHIMA., T., T., SAITO, SAITO., N., N., HONZAWA, HONZAWA., S., S., KISHIMOTO, KISHIMOTO., SUGIURA, SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA. & A., H. KITTAKA., 2004 Jan 1, In : Heterocycles. 62, p. 426-436

Research output: Contribution to journalArticle

Synthesis of novel 1α,25-dihydroxy-19-norvitamin D3 with an amide conjugate

Suhara, Y., Ono, K., Yoshida, A., Fujishima, T., Saito, N., Honzawa, S., Kishimoto, S., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2004 Jan 1, In : Heterocycles. 62, p. 423-436 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2003

2alpha -(3-Hydroxypropyl)- and 2 alpha-(3-Hydroxypropyl)-1alpha ,25-dihydroxyvitamin D3 accessible to Vitamin D Receptor Mutant Related to Hereditary Vitamin D-Resistant Rickets

KITTAKA, KITTAKA., A., A., KURIHARA, KURIHARA., M., M., PLEG, PLEG., S., S., SUHARA, SUHARA., Y., Y., TAKAYAMA, TAKAYAMA. & H., H., 2003 Mar 1, In : Chemical & Pharmaceutical Bulletin. 51, p. 357-358

Research output: Contribution to journalArticle

28 Citations (Scopus)

2 α-(3-hydroxypropyl)- and 2 α-(3-hydroxypropoxy)-1 α,25-dihydroxyvitamin D3 accessible to vitamin D receptor mutant related to hereditary vitamin D-resistant rickets

Kittaka, A., Kurihara, M., Peleg, S., Suhara, Y. & Takayama, H., 2003 Mar, In : Chemical and Pharmaceutical Bulletin. 51, 3, p. 357-358 2 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Concise Synthesis and Biological Activities of 2alpha-Alkyl- and 2 alpha-( omega-Hydroxyalkyl)-20-epi-1 alpha,25-dihydroxyvitamin D3

HONZAWA, HONZAWA., S., S., SUHARA, SUHARA., Y., Y., NIHEI, NIHEI., K., K., SAITO, SAITO., N., N., KISHIMOTO, KISHIMOTO., FUJISHIMA, FUJISHIMA., T., T., KURIHARA, KURIHARA., M.:SUGIURA, M. SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA., H., H. & A., KITTAKA., 2003 Oct 1, In : Bioorganic & Medicinal Chemistry. 13, p. 3503-3506

Research output: Contribution to journalArticle

24 Citations (Scopus)

Concise synthesis and biological activities of 2α-alkyl- and 2α-(ω-hydroxyalkyl)-20-epi-1α,25-dihydroxyvitamin D 3

Honzawa, S., Suhara, Y., Nihei, K. I., Saito, N., Kishimoto, S., Fujishima, T., Kurihara, M., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2003 Oct 20, In : Bioorganic and Medicinal Chemistry Letters. 13, 20, p. 3503-3506 4 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Design, synthesis, and biological studies of the A-ring-modified 1,25-dihydroxyvitamin D3 analogs

TAKAYAMA, TAKAYAMA., H., H., KITTAKA, KITTAKA., A., A., FUJISHIMA, FUJISHIMA., T., T., SUHARA, SUHARA. & Y., Y., 2003 May 1, In : Recent Results in Cancer Research164 (Vitamin D Analogs in Cancer Prevention and Therapy). 164, p. 289-317

Research output: Contribution to journalArticle

25 Citations (Scopus)
25 Citations (Scopus)

Efficient and Convergent Coupling Route for the Short-step Synthesis of Enantiopure 2alpha - and 2beta -Alkylated 1alpha ,25-Dihydroxy-19-norvitamin D3 Analogues

YOSHIDA, YOSHIDA., A., A., ONO, ONO., K., K., SUHARA, SUHARA., Y., Y., SAITO, SAITO., N., N., TAKAYAMA, TAKAYAMA., H., H. & KITTAKA, KITTAKA., 2003 Jun 1, In : Synlett. 8, p. 1175-1179

Research output: Contribution to journalArticle

Efficient and convergent coupling route for the short-step synthesis of enantiopure 2α- and 2β-alkylated 1α,25-dihydroxy-19-norvitamin D3 analogues

Yoshida, A., Ono, K., Suhara, Y., Saito, N., Takayama, H. & Kittaka, A., 2003, In : Synlett. 8, p. 1175-1179 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Efficient Synthesis of 2-Modified 1 alpha,25-Dihydroxy-19-norvitamin D3 with Julia Olefination: High Potency in Induction of Differentiation on HL-60 Cells

ONO, ONO., K., K., YOSHIDA, YOSHIDA., A., A., SAITO, SAITO., N., N., FUJISHIMA, FUJISHIMA., T., T., HONZAWA, HONZAWA., S., S., SUHARA, SUHARA., Y., Y., KISHIMOTO, KISHIMOTO., SUGIURA, SUGIURA., WAKU, WAKU., TAKAYAMA, TAKAYAMA. & A., H. KITTAKA., 2003 Aug 1, In : Journal of Organic Chemistry. 68, p. 7407-7415

Research output: Contribution to journalArticle

96 Citations (Scopus)

Efficient synthesis of 2-modified 1α,25-dihydroxy-19-norvitamin D3 with Julia olefination: High potency in induction of differentiation on HL-60 cells

Ono, K., Yoshida, A., Saito, N., Fujishima, T., Honzawa, S., Suhara, Y., Kishimoto, S., Sugiura, T., Waku, K., Takayama, H. & Kittaka, A., 2003 Sep 19, In : Journal of Organic Chemistry. 68, 19, p. 7407-7415 9 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Ether-linked analogue of 2-arachidonoylglycerol (noladin ether) was not detected in the brains of various mammalian species

Oka, S., Tsuchie, A., Tokumura, A., Muramatsu, M., Suhara, Y., Takayama, H., Waku, K. & Sugiura, T., 2003 Jun, In : Journal of Neurochemistry. 85, 6, p. 1374-1381 8 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)
2002

Design and Efficient Syntheses of New Stable 1 alpha,25-Dihydroxyvitamin D3 Analogues Containing Amide-bond

SUHARA, SUHARA., Y, Y., KITTAKA, KITTAKA., A., A., ONO, ONO., K., K., FUJISHIMA, FUJISHIMA., T., T., YOSHIDA, YOSHIDA., TAKAYAMA, TAKAYAMA. & H., H., 2002 Dec 1, In : Bioorganic & Medicinal Chemistry Letters. 12, p. 3533-3536

Research output: Contribution to journalArticle

14 Citations (Scopus)

Design and efficient synthesis of new stable 1α,25-dihydroxy-19-norvitamin D3 analogues containing amide bond

Suhara, Y., Kittaka, A., Ono, K., Kurihara, M., Fujishima, T., Yoshida, A. & Takayama, H., 2002 Dec, In : Bioorganic and Medicinal Chemistry Letters. 12, 24, p. 3533-3536 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Oligomers of glycamino acid

Suhara, Y., Yamaguchi, Y., Collins, B., Schnaar, R. L., Yanagishita, M., Hildreth, J. E. K., Shimada, I. & Ichikawa, Y., 2002, In : Bioorganic and Medicinal Chemistry. 10, 6, p. 1999-2013 15 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Synthesis and biological activity of the A-ring modified 1α, 25-dihydroxyvitamin D3

Takayama, H., Kittaka, A., Fujishima, T. & Suhara, Y., 2002 Apr, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 60, 4, p. 370-382 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Synthesis and Testing of 2 alpha-Modified 1 alpha,25-Dihydroxyvitamin D3 Analogues with a Double Side Chain: Marked Cell Differenciation Activity

SUHARA, SUHARA., Y, Y., KITTAKA, KITTAKA., A., A., KISHIMOTO, KISHIMOTO., S., S., CALVERLEY, CALVERLEY., M., J., FUJISHIMA, FUJISHIMA., T., T., SAITO, SAITO., N., N., SUGIURA, SUGIURA., WAKU, WAKU., K., K., TAKAYAMA, TAKAYAMA. & H., H., 2002 Dec 1, In : Bioorganic & Medicinal Chemistry Letters. 12, p. 3255-3258

Research output: Contribution to journalArticle

26 Citations (Scopus)

Synthesis and testing of 2α-Modified 1α,25-Dihydroxyvitamin D3 analogues with a double side chain: Marked cell differentiation activity

Suhara, Y., Kittaka, A., Kishimoto, S., Calverley, M. J., Fujishima, T., Saito, N., Sugiura, T., Waku, K. & Takayama, H., 2002 Nov 18, In : Bioorganic and Medicinal Chemistry Letters. 12, 22, p. 3255-3258 4 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2001

Efficient and Versatile Synthesis of Novel 2alpha -Substituted 1alpha ,25-Dihydroxyvitamin D3 Analogues and Their Docking to Vitamin D Receptors

SUHARA, SUHARA., Y, Y., NIHEI, NIHEI., K., K., KURIHARA, KURIHARA., M., M., KITTAKA, KITTAKA., A., A., YAMAGUCHI, YAMAGUCHI., FUJISHIMA, FUJISHIMA., T., T., KONNO, KONNO., MIYATA, MIYATA., N., N., TAKAYAMA, TAKAYAMA. & H., H., 2001 Nov 1, In : Journal of Organic Chemistry. 66, p. 8760-8771

Research output: Contribution to journalArticle

92 Citations (Scopus)

Efficient and versatile synthesis of novel 2α-substituted 1α,25-dihydroxyvitamin D3 analogues and their docking to vitamin D receptors

Suhara, Y., Nihei, K. I., Kurihara, M., Kittaka, A., Yamaguchi, K., Fujishima, T., Konno, K., Miyata, N. & Takayama, H., 2001 Dec 28, In : Journal of Organic Chemistry. 66, 26, p. 8760-8771 12 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand

Suhara, Y., Nakane, S., Arai, S., Takayama, H., Waku, K., Ishima, Y. & Sugiura, T., 2001 Aug 6, In : Bioorganic and Medicinal Chemistry Letters. 11, 15, p. 1985-1988 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2000

A Concise and Efficient Route to 2 alfa-( omega-Hydroxyalkoxy)-1alpha ,25-dihydroxyvitamin D3: Remarkably High Affinity to Vitamin D Receptor

KITTAKA, KITTAKA., A., A., SUHARA, SUHARA., Y., Y., TAKAYANAGI, TAKAYANAGI., H., H., FUJISHIMA, FUJISHIMA., T., T. & TAKAYAMA, TAKAYAMA., 2000 Aug 1, In : Organic Letters. 2, p. 2619-2622

Research output: Contribution to journalArticle

80 Citations (Scopus)