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Author

  • Yoshitomo Suhara
2014

Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice

Nakagawa, K., Sawada, N., Hirota, Y., Uchino, Y., Suhara, Y., Hasegawa, T., Amizuka, N., Okamoto, T., Tsugawa, N., Kamao, M., Funahashi, N. & Okano, T., 2014, In : PLoS One. 9, 8, p. e104078

Research output: Contribution to journalArticle

19 Citations (Scopus)
2017

Substitution at the C-3 position of catechins has an influence on the binding affinities against serum albumin

Ikeda, M., Ueda-Wakagi, M., Hayashibara, K., Kitano, R., Kawase, M., Kaihatsu, K., Kato, N., Suhara, Y., Osakabe, N. & Ashida, H., 2017 Feb 1, In : Molecules. 22, 2, 314.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2016

The impact of theaflavins on systemic-and microcirculation alterations: The murine and randomized feasibility trials

Saito, A., Nakazato, R., Suhara, Y., Shibata, M., Fukui, T., Ishii, T., Asanuma, T., Mochizuki, K., Nakayama, T. & Osakabe, N., 2016 Jun 1, In : Journal of Nutritional Biochemistry. 32, p. 107-114 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

A single oral dose of flavan-3-ols enhances energy expenditure by sympathetic nerve stimulation in mice

Kamio, N., Suzuki, T., Watanabe, Y., Suhara, Y. & Osakabe, N., 2016 Feb 1, In : Free Radical Biology and Medicine. 91, p. 256-263 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2011

Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: Insights into the biological role of the side chain part of vitamin K

SUHARA, SUHARA., Y., Y., WATANABE, WATANABE., M., M., MOTOYOSHI, MOTOYOSHI., S., S., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA., H., H., OKANO, OKANO. & T., T., 2011 Dec 1, In : Default journal. p. 177-177

Research output: Contribution to journalArticle

19 Citations (Scopus)
2015

YY1 positively regulates human UBIAD1 expression

Funahashi, N., Hirota, Y., Nakagawa, K., Sawada, N., Watanabe, M., Suhara, Y. & Okano, T., 2015 May 1, In : Biochemical and Biophysical Research Communications. 460, 2, p. 238-244 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Functional characterization of the vitamin K<inf>2</inf> biosynthetic enzyme UBIAD1

Hirota, Y., Nakagawa, K., Sawada, N., Okuda, N., Suhara, Y., Uchino, Y., Kimoto, T., Funahashi, N., Kamao, M., Tsugawa, N. & Okano, T., 2015 Apr 15, In : PLoS One. 10, 4, e0125737.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2013

Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11

Edson, K. Z., Prasad, B., Unadkat, J. D., Suhara, Y., Okano, T., Peter Guengerich, F. & Rettie, A. E., 2013 Nov 19, In : Biochemistry. 52, 46, p. 8276-8285 10 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2018

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice

Hirota, Y., Nakagawa, K., Isomoto, K., Sakaki, T., Kubodera, N., Kamao, M., Osakabe, N., Suhara, Y. & Okano, T., 2018 Oct 1, In : PLoS One. 13, 10, e0199856.

Research output: Contribution to journalArticle

2013

Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance

Li, Q., Qi, J., Wu, Y., Kiyota, H., Tanaka, K., Suhara, Y., Ohrui, H., Suzuki, Y., Vavricka, C. J. & Gao, G. F., 2013, In : Journal of Virology. 87, 18, p. 10016-10024 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2019
Open Access
3 Citations (Scopus)
2011

Synthesis of Novel Vitamin K2 Analogues with Modification at the ω-Terminal Position and their Biological Evaluation as Potent Steroid and Xenobiotic Receptor (SXR) Agonists

SUHARA, SUHARA., Y, Y., Y., Y., WATANABE, WATANABE., M., M., NAKAGWA, NAKAGWA., K., K., WADA, WADA., A., A., ITO, ITO., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., OKANO, OKANO. & T., T., 2011 May 11, In : Jornal of Medicinal Chemistry. 54, p. 4269-4273

Research output: Contribution to journalArticle

7 Citations (Scopus)
2012

Structure-Activity Relationship of Novel Menaquinone-4 Analogues: Modification of the Side Chain Affects their Biological Activities

SUHARA, SUHARA., Y., Y., HANADA, HANADA., N., N., OKITSU, OKITSU., T., T., SAKAI, SAKAI., M., M., WATANABE, WATANABE., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA. & T., H. . OKANO., 2012 Jan 17, In : Journal of Medicinal Chemistry. 55, p. 1553-1558

Research output: Contribution to journalArticle

9 Citations (Scopus)
2017

Determination of menadione by liquid chromatography-tandem mass spectrometry using pseudo multiple reaction monitoring

Kamao, M., Hirota, Y., Suhara, Y., Tsugawa, N., Nakagawa, K., Okano, T. & Hasegawa, H., 2017, In : Analytical Sciences. 33, 7, p. 863-867 5 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)
2015

Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells

Suhara, Y., Hirota, Y., Hanada, N., Nishina, S., Eguchi, S., Sakane, R., Nakagawa, K., Wada, A., Takahashi, K., Tokiwa, H. & Okano, T., 2015 Sep 10, In : Journal of Medicinal Chemistry. 58, 17, p. 7088-7092 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2018

Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice

Nakagawa, Y., Ishimura, K., Oya, S., Kamino, M., Fujii, Y., Nanba, F., Toda, T., Ishii, T., Adachi, T., Suhara, Y. & Osakabe, N., 2018 Jul 1, In : PLoS One. 13, 7, e0201203.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2011

Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: Insights into the biological role of the side chain part of vitamin K

Suhara, Y., Watanabe, M., Motoyoshi, S., Nakagawa, K., Wada, A., Takeda, K., Takahashi, K., Tokiwa, H. & Okano, T., 2011 Jul 14, In : Journal of Medicinal Chemistry. 54, 13, p. 4918-4922 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2012

Structure-activity relationship of novel menaquinone-4 analogues: Modification of the side chain affects their biological activities

Suhara, Y., Hanada, N., Okitsu, T., Sakai, M., Watanabe, M., Nakagawa, K., Wada, A., Takeda, K., Takahashi, K., Tokiwa, H. & Okano, T., 2012 Feb 23, In : Journal of Medicinal Chemistry. 55, 4, p. 1553-1558 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2019

Synthesis and in vitro evaluation of novel liver X receptor agonists based on naphthoquinone derivatives

Nishioka, T., Endo-Umeda, K., Ito, Y., Shimoda, A., Takeuchi, A., Tode, C., Hirota, Y., Osakabe, N., Makishima, M. & Suhara, Y., 2019 Nov 26, In : Molecules. 24, 23, 4316.

Research output: Contribution to journalArticle

Open Access

Elucidation of the interaction between flavan-3-ols and bovine serum albumin and its effect on their in-vitro cytotoxicity

Fujii, Y., Suhara, Y., Sukikara, Y., Teshima, T., Hirota, Y., Yoshimura, K. & Osakabe, N., 2019 Oct 11, In : Molecules. 24, 20, 3667.

Research output: Contribution to journalArticle

Open Access
2017

Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice

Hirota, Y., Nakagawa, K., Mimatsu, S., Sawada, N., Sakaki, T., Kubodera, N., Kamao, M., Tsugawa, N., Suhara, Y. & Okano, T., 2017 Jan 29, In : Biochemical and Biophysical Research Communications. 483, 1, p. 359-365 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2011

Synthesis of novel vitamin K2 analogues with modification at the Ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists

Suhara, Y., Watanabe, M., Nakagawa, K., Wada, A., Ito, Y., Takeda, K., Takahashi, K. & Okano, T., 2011 Jun 23, In : Journal of Medicinal Chemistry. 54, 12, p. 4269-4273 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2019

UBIAD1 Plays an Essential Role in the Survival of Pancreatic Acinar Cells

Nakagawa, K., Fujiwara, K., Nishimura, A., Murakami, C., Kawamoto, K., Ichinose, C., Kunitou, Y., Suhara, Y., Okano, T. & Hasegawa, H., 2019 Apr 22, In : International journal of molecular sciences. 20, 8

Research output: Contribution to journalArticle

Open Access
2015

A single oral administration of theaflavins increases energy expenditure and the expression of metabolic genes

Kudo, N., Arai, Y., Suhara, Y., Ishii, T., Nakayama, T. & Osakabe, N., 2015 Sep 16, In : PLoS One. 10, 9, e0137809.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2013

Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats

Hirota, Y., Tsugawa, N., Nakagawa, K., Suhara, Y., Tanaka, K., Uchino, Y., Takeuchi, A., Sawada, N., Kamao, M., Wada, A., Okitsu, T. & Okano, T., 2013 Nov 15, In : Journal of Biological Chemistry. 288, 46, p. 33071-33080 10 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
2011

Synthesis of New Vitamin K Analogues as Steroid and Xenobiotic Receptor Agonists: Insight into the Biological Role of the Side Chain Part of Vitamin K

SUHARA, SUHARA., Y, Y., Y., Y., WATANABE, WATANABE., M., M., MOTOYOSHI, MOTOYOSHI., S., S., NAKAGAWA, NAKAGAWA., K., K., WADA, WADA., A., A., TAKEDA, TAKEDA., TAKAHASHI, TAKAHASHI., TOKIWA, TOKIWA., H., H., OKANO, OKANO. & T., T., 2011 May 27, In : Jornal of Medicinal Chemistry. 54, p. 4918-4922

Research output: Contribution to journalArticle

19 Citations (Scopus)
2017

Synthesis of novel vitamin K derivatives with alkylated phenyl groups introduced at the ω-terminal side chain and evaluation of their neural differentiation activities

Sakane, R., Kimura, K., Hirota, Y., Ishizawa, M., Takagi, Y., Wada, A., Kuwahara, S., Makishima, M. & Suhara, Y., 2017 Nov 1, In : Bioorganic and Medicinal Chemistry Letters. 27, 21, p. 4881-4884 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
8 Citations (Scopus)