A functional balance evaluation system for limb paresthesia mouse - Comparison between rotor rod and oscillating disk stage

Kengo Ohnishi, Takashi Komeda, Yukio Saito

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The production and rearing of knockout mice, which are house mice with targeted congenital deficiency, contributes greatly for the advances of health science and genetic technology. The mouse with deficiency in the gene possesses the characteristic such as compromised immune system. Meanwhile, partial of the genes of the knockout mouse are intentionally compromised, yet the level of physical fitness or disability are not uniform and quite variable. Therefore, when anticipating them in the experiment on sensory and motor performance, the biography and medical record of the knockout mice are required along with their physical fitness and level of disability. The problem of the individual record is that the current physical fitness and level of disability assessment's accuracy and precision are low. This is due to the lack of instrumentation device and analysis system for testing the balance control ability of mouse. The conventional test with rotor rod device can be used for slight to mild disability mouse, but not appropriate for assessing severe limb paresthesia mouse. This research targets to develop a system to measure the behavior and posture controllability of laboratory mouse. In the experiment, normal mice's balance ability and knockout mice with cerebellum genetically modified are evaluated. Quality Engineering Mahalanobis-Taguchi System is applied for numerical analysis and quantitative evaluation of each mice group's characteristic feature and compared between the experiment devices to discuss the detection resolution. The Posture Control Evaluation System with the oscillating disk stage had preferable properties compared to rotor rod test.

Original languageEnglish
Title of host publication2016 11th France-Japan and 9th Europe-Asia Congress on Mechatronics, MECATRONICS 2016 / 17th International Conference on Research and Education in Mechatronics, REM 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages80-85
Number of pages6
ISBN (Electronic)9781509017874
DOIs
Publication statusPublished - 2016 Aug 17
Event11th France-Japan and 9th Europe-Asia Congress on Mechatronics, MECATRONICS 2016 / 17th International Conference on Research and Education in Mechatronics, REM 2016 - Compiegne, France
Duration: 2016 Jun 152016 Jun 17

Other

Other11th France-Japan and 9th Europe-Asia Congress on Mechatronics, MECATRONICS 2016 / 17th International Conference on Research and Education in Mechatronics, REM 2016
CountryFrance
CityCompiegne
Period16/6/1516/6/17

Keywords

  • Balance Ability
  • Knockout Mouse
  • Laboratory Neuralscience Research Device
  • Mahalanobis Taguchi System

ASJC Scopus subject areas

  • Mechanical Engineering
  • Modelling and Simulation
  • Education
  • Artificial Intelligence
  • Electrical and Electronic Engineering

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  • Cite this

    Ohnishi, K., Komeda, T., & Saito, Y. (2016). A functional balance evaluation system for limb paresthesia mouse - Comparison between rotor rod and oscillating disk stage. In 2016 11th France-Japan and 9th Europe-Asia Congress on Mechatronics, MECATRONICS 2016 / 17th International Conference on Research and Education in Mechatronics, REM 2016 (pp. 80-85). [7547120] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MECATRONICS.2016.7547120