A microfluidic model of cardiovascular bubble lodging

Joseph L. Bull, Yun Seok Heo, Nobuyuki Futai, J. Brian Fowlkes, Andrés J. Calderón, Dongeun Huh, Shuichi Takayama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Embolotherapy involves the occlusion of blood flow to tumors to treat a variety of cancers, including renal carcinoma and hepatocellular carcinoma. The accompanying liver cirrhosis makes the treatment of hepatocellular carcinoma by traditional methods difficult. Previous attempts at embolotherapy have used solid emboli. A major difficulty in embolotherapy is restricting delivery of the emboli to the tumor. We are developing a novel minimally invasive gas embolotherapy technique that uses gas bubbles rather than solid emboli. The bubbles originate as encapsulated liquid droplets that are small enough to pass through capillaries. The droplets can be selectively vaporized in vivo by focused high intensity ultrasound to form gas bubbles which are then sufficiently large to lodge in the tumor vasculature. We investigated the dynamics of bubble lodging in microfluidic model bifurcations made of poly(dimethylsiloxane) and in theoretical analyses. The results show that the critical driving pressure below which a bubble will lodge in a bifurcation is significantly less than the driving pressure required to dislodge it. Based these results, we estimate that gas bubbles from embolotherapy can lodge in vessels 20 μm or smaller in diameter, and conclude that bubbles may potentially be used to reduce blood flow to tumor microcirculation.

Original languageEnglish
Title of host publication2007 Proceedings of the 5th Joint ASME/JSME Fluids Engineering Summer Conference, FEDSM 2007
Pages691-694
Number of pages4
EditionPART A
DOIs
Publication statusPublished - 2007 Dec 1
Event2007 5th Joint ASME/JSME Fluids Engineering Summer Conference, FEDSM 2007 - San Diego, CA, United States
Duration: 2007 Jul 302007 Aug 2

Publication series

Name2007 Proceedings of the 5th Joint ASME/JSME Fluids Engineering Summer Conference, FEDSM 2007
NumberPART A
Volume2 FORA

Conference

Conference2007 5th Joint ASME/JSME Fluids Engineering Summer Conference, FEDSM 2007
CountryUnited States
CitySan Diego, CA
Period07/7/3007/8/2

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ASJC Scopus subject areas

  • Mechanical Engineering
  • Condensed Matter Physics

Cite this

Bull, J. L., Heo, Y. S., Futai, N., Fowlkes, J. B., Calderón, A. J., Huh, D., & Takayama, S. (2007). A microfluidic model of cardiovascular bubble lodging. In 2007 Proceedings of the 5th Joint ASME/JSME Fluids Engineering Summer Conference, FEDSM 2007 (PART A ed., pp. 691-694). (2007 Proceedings of the 5th Joint ASME/JSME Fluids Engineering Summer Conference, FEDSM 2007; Vol. 2 FORA, No. PART A). https://doi.org/10.1115/FEDSM2007-37446