A microfluidic model of microbubble lodging in small arteriole bifurcations

Joseph L. Bull, Andrés J. Calderón, Yunseok Heo, Dongeun Huh, Futai Nobuyuki, Shuichi Takayama, J. Brian Fowlkes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Lodging of cardiovascular gas bubbles is investigated in a microfluidic model of small arteriole bifurcations. This work is motivated by a novel gas embolotherapy technique for the potential treatment of cancer by tumor infarction and by air embolism. The experimental model arteriole bifurcations were constructed from a transparent elastomer, poly(dimethylsiloxane), using soft lithography. A single air bubble was suspended in water within the parent tube of the bifurcation and a specified driving pressure was imposed via constant elevation reservoirs that were open to atmospheric pressure. The driving pressure and bubble size were varied, and their effects on the bubble lodging were assessed. These findings may be useful in developing strategies for microbubble delivery in gas embolotherapy.

Original languageEnglish
Title of host publication2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Pages290-291
Number of pages2
DOIs
Publication statusPublished - 2005 Dec 1
Event2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology - Oahu, HI, United States
Duration: 2005 May 122005 May 15

Publication series

Name2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Volume2005

Conference

Conference2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
CountryUnited States
CityOahu, HI
Period05/5/1205/5/15

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Keywords

  • Air embolism
  • Cardiovascular emboli
  • Gas embolotherapy
  • Microfluidics
  • Soft lithography

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Bull, J. L., Calderón, A. J., Heo, Y., Huh, D., Nobuyuki, F., Takayama, S., & Fowlkes, J. B. (2005). A microfluidic model of microbubble lodging in small arteriole bifurcations. In 2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology (pp. 290-291). [1548451] (2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology; Vol. 2005). https://doi.org/10.1109/MMB.2005.1548451