A new stiffness evaluation toward high speed cell sorter

Yuki Hirose, Kenjiro Tadakuma, Mitsuru Higashimori, Tatsuo Arai, Makoto Kaneko, Ryo Iitsuka, Yoko Yamanishi, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

36 Citations (Scopus)

Abstract

Cell stiffness could be an index for evaluating its activity. Although various systems measuring cell stiffness have been proposed so far, they are slow for adaptively connecting to cell sorters capable of handling more than 1000 [cells/sec]. This paper proposes a new approach that can indirectly evaluate the cell stiffness by measuring the passing time for a narrow channel. When a cell passes through the channel, it receives a viscous force depending upon how much deformation is exerted on the cell. We show that the stiffness is a function of both the passing time and the initial diameter of cell. We also show that the stiffness is proportional to the passing time and inversely proportional to the initial diameter, under the assumption that the thickness of fluid film is inversely proportional to the normal force. The experimental validation is given together with the basic working principle.

Original languageEnglish
Title of host publicationProceedings - IEEE International Conference on Robotics and Automation
Pages4113-4118
Number of pages6
DOIs
Publication statusPublished - 2010
Externally publishedYes
Event2010 IEEE International Conference on Robotics and Automation, ICRA 2010 - Anchorage, AK
Duration: 2010 May 32010 May 7

Other

Other2010 IEEE International Conference on Robotics and Automation, ICRA 2010
CityAnchorage, AK
Period10/5/310/5/7

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Stiffness
Fluids

ASJC Scopus subject areas

  • Software
  • Artificial Intelligence
  • Control and Systems Engineering
  • Electrical and Electronic Engineering

Cite this

Hirose, Y., Tadakuma, K., Higashimori, M., Arai, T., Kaneko, M., Iitsuka, R., ... Arai, F. (2010). A new stiffness evaluation toward high speed cell sorter. In Proceedings - IEEE International Conference on Robotics and Automation (pp. 4113-4118). [5509970] https://doi.org/10.1109/ROBOT.2010.5509970

A new stiffness evaluation toward high speed cell sorter. / Hirose, Yuki; Tadakuma, Kenjiro; Higashimori, Mitsuru; Arai, Tatsuo; Kaneko, Makoto; Iitsuka, Ryo; Yamanishi, Yoko; Arai, Fumihito.

Proceedings - IEEE International Conference on Robotics and Automation. 2010. p. 4113-4118 5509970.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hirose, Y, Tadakuma, K, Higashimori, M, Arai, T, Kaneko, M, Iitsuka, R, Yamanishi, Y & Arai, F 2010, A new stiffness evaluation toward high speed cell sorter. in Proceedings - IEEE International Conference on Robotics and Automation., 5509970, pp. 4113-4118, 2010 IEEE International Conference on Robotics and Automation, ICRA 2010, Anchorage, AK, 10/5/3. https://doi.org/10.1109/ROBOT.2010.5509970
Hirose Y, Tadakuma K, Higashimori M, Arai T, Kaneko M, Iitsuka R et al. A new stiffness evaluation toward high speed cell sorter. In Proceedings - IEEE International Conference on Robotics and Automation. 2010. p. 4113-4118. 5509970 https://doi.org/10.1109/ROBOT.2010.5509970
Hirose, Yuki ; Tadakuma, Kenjiro ; Higashimori, Mitsuru ; Arai, Tatsuo ; Kaneko, Makoto ; Iitsuka, Ryo ; Yamanishi, Yoko ; Arai, Fumihito. / A new stiffness evaluation toward high speed cell sorter. Proceedings - IEEE International Conference on Robotics and Automation. 2010. pp. 4113-4118
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