A new stiffness evaluation toward high speed cell sorter

Yuki Hirose, Kenjiro Tadakuma, Mitsuru Higashimori, Tatsuo Arai, Makoto Kaneko, Ryo Iitsuka, Yoko Yamanishi, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

39 Citations (Scopus)

Abstract

Cell stiffness could be an index for evaluating its activity. Although various systems measuring cell stiffness have been proposed so far, they are slow for adaptively connecting to cell sorters capable of handling more than 1000 [cells/sec]. This paper proposes a new approach that can indirectly evaluate the cell stiffness by measuring the passing time for a narrow channel. When a cell passes through the channel, it receives a viscous force depending upon how much deformation is exerted on the cell. We show that the stiffness is a function of both the passing time and the initial diameter of cell. We also show that the stiffness is proportional to the passing time and inversely proportional to the initial diameter, under the assumption that the thickness of fluid film is inversely proportional to the normal force. The experimental validation is given together with the basic working principle.

Original languageEnglish
Title of host publication2010 IEEE International Conference on Robotics and Automation, ICRA 2010
Pages4113-4118
Number of pages6
DOIs
Publication statusPublished - 2010 Aug 26
Event2010 IEEE International Conference on Robotics and Automation, ICRA 2010 - Anchorage, AK, United States
Duration: 2010 May 32010 May 7

Publication series

NameProceedings - IEEE International Conference on Robotics and Automation
ISSN (Print)1050-4729

Other

Other2010 IEEE International Conference on Robotics and Automation, ICRA 2010
CountryUnited States
CityAnchorage, AK
Period10/5/310/5/7

ASJC Scopus subject areas

  • Software
  • Control and Systems Engineering
  • Artificial Intelligence
  • Electrical and Electronic Engineering

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  • Cite this

    Hirose, Y., Tadakuma, K., Higashimori, M., Arai, T., Kaneko, M., Iitsuka, R., Yamanishi, Y., & Arai, F. (2010). A new stiffness evaluation toward high speed cell sorter. In 2010 IEEE International Conference on Robotics and Automation, ICRA 2010 (pp. 4113-4118). [5509970] (Proceedings - IEEE International Conference on Robotics and Automation). https://doi.org/10.1109/ROBOT.2010.5509970