Abstract
We propose a novel ethylenediamine plasma-polymerized film matrix that is deposited on gold surfaces for use in surface plasmon resonance immunosensing. The films formed on the gold surfaces are extremely thin (∼100 nm), are homogeneous, demonstrate good adhesion, have a flat profile, and incorporate amino groups to introduce a chemical functionality. A sensor chip made with the film has many advantages when compared with conventionally used designs such as carboxylated dextran hydrogels. For example, a sensor chip made with the film shows a better sensor response than a conventional design partly because antibodies are densely and two-dimensionally immobilized onto the surface of the plasma-polymerized film.
| Original language | English |
|---|---|
| Pages (from-to) | 4649-4652 |
| Number of pages | 4 |
| Journal | Analytical Chemistry |
| Volume | 69 |
| Issue number | 22 |
| DOIs | |
| Publication status | Published - 1997 Nov 15 |
| Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
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Cite this
Nakamura, R., Muguruma, H., Ikebukuro, K., Sasaki, S., Nagata, R., Karube, I., & Pedersen, H. (1997). A Plasma-Polymerized Film for Surface Plasmon Resonance Immunosensing. Analytical Chemistry, 69(22), 4649-4652. https://doi.org/10.1021/ac970571i