A symmetrical dorsal island double flap in the mouse

S. Ichioka, S. Kudo, K. Tokioka, M. Shibata, J. Ando, N. Sekiya, T. Nakatsuka

Research output: Contribution to journalArticle

Abstract

The mouse is currently recognized as the most advantageous experimental animal amongst the muridae because of its small size, universal availability, and the large variety of lines available including disease models. We propose a new axial-pattern double flap model which allows symmetrical preparation of two flaps, reducing difficulties regarding inter-animal variation. Two symmetrical island flaps were harvested based on the bilateral deep circumflex iliac arteries (DCIAs) and subjected to ischaemia followed by reperfusion. On postoperative day 7, the flap survival area was measured. Comparison between the right and left flap in each animal showed an almost identical survival area. The model provides a reliable experimental means for research in flap pathophysiology. It could be especially useful for estimating effects of topical therapeutic manipulation to individual flaps including local application of agents and cell and/or gene transplantation.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalEuropean Journal of Plastic Surgery
Volume27
Issue number1
DOIs
Publication statusPublished - 2004 Apr 1

Keywords

  • Experimental flap
  • Ischaemia-reperfusion injury
  • Mouse

ASJC Scopus subject areas

  • Surgery

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    Ichioka, S., Kudo, S., Tokioka, K., Shibata, M., Ando, J., Sekiya, N., & Nakatsuka, T. (2004). A symmetrical dorsal island double flap in the mouse. European Journal of Plastic Surgery, 27(1), 29-32. https://doi.org/10.1007/s00238-004-0600-7