A synthetic replica having surface morphology of decellularized tissue regulated orientation and shape of cells

Tsuvoshi Kimura, Mako Kobayashi, Yoshihide Hashimoto, Toshiya Fujisato, Naoko Nakamura, Akio Kisliida

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Decellularized tissues, which are extracellular matrix assembly prepared from living tissue, are tried to apply for regenerative medicine and to be used as biomaterials because of the good biocompatibility. Recently, many researchers are challenging to resolve its mechanism, but it is still unclear. Previously, our group also reported that decellularized tissues were prepared by high hydrostatic pressure (HHP) technology and they showed good biocompatibility [1]. Especially, decellularized aorta showed good patency and early endothelialization for in vivo vascular replacement [2].One possible reason is that HHP decellularized luminal surface remains the similar morphology to native aortic lumenal surface. In this study, we investigated the surface morphology of aortic lumen prepared by various decellularization methods using HHP and SDS, and synthetic replicas were prepared by a transferring method using poly(dimethyl siloxane) (PDMS). The endothelial cell behavior on them was investigated (Figure 1).

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
Publication statusPublished - 2019 Jan 1
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: 2019 Apr 32019 Apr 6

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period19/4/319/4/6

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Kimura, T., Kobayashi, M., Hashimoto, Y., Fujisato, T., Nakamura, N., & Kisliida, A. (2019). A synthetic replica having surface morphology of decellularized tissue regulated orientation and shape of cells. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.