Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

Seigo Baba, Naomi Osakabe, Midori Natsume, Junji Terao

Research output: Contribution to journal › Article › peer-review

195 Citations (Scopus)

Abstract

We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.

Original languageEnglish
Pages (from-to)142-148
Number of pages7
JournalFree Radical Biology and Medicine
Volume33
Issue number1
DOIs
Publication statusPublished - 2002 Jul 1
Externally publishedYes

Keywords

  • (-)-Epicatechin
  • Absorption
  • Antioxidant
  • Conjugation
  • Degradation
  • Free radicals
  • Methylation
  • Procyanidin B2
  • Rats
  • Urinary excretion

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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