Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

Seigo Baba; Naomi Osakabe; Midori Natsume; Junji Terao

doi:10.1016/S0891-5849(02)00871-7

Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

Seigo Baba, Naomi Osakabe, Midori Natsume, Junji Terao

Research output: Contribution to journal › Article › peer-review

196 Citations (Scopus)

Abstract

We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.

Original language	English
Pages (from-to)	142-148
Number of pages	7
Journal	Free Radical Biology and Medicine
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/S0891-5849(02)00871-7
Publication status	Published - 2002 Jul 1
Externally published	Yes

Keywords

(-)-Epicatechin
Absorption
Antioxidant
Conjugation
Degradation
Free radicals
Methylation
Procyanidin B2
Rats
Urinary excretion

ASJC Scopus subject areas

Biochemistry
Physiology (medical)

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abstract = "We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.",

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T1 - Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

AU - Baba, Seigo

AU - Osakabe, Naomi

AU - Natsume, Midori

AU - Terao, Junji

PY - 2002/7/1

Y1 - 2002/7/1

N2 - We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.

AB - We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.

KW - (-)-Epicatechin

KW - Absorption

KW - Antioxidant

KW - Conjugation

KW - Degradation

KW - Free radicals

KW - Methylation

KW - Procyanidin B2

KW - Rats

KW - Urinary excretion

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ER -

Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

Abstract

Keywords

ASJC Scopus subject areas

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