Abstract
We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.
| Original language | English |
|---|---|
| Pages (from-to) | 142-148 |
| Number of pages | 7 |
| Journal | Free Radical Biology and Medicine |
| Volume | 33 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2002 Jul 1 |
| Externally published | Yes |
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Keywords
- (-)-Epicatechin
- Absorption
- Antioxidant
- Conjugation
- Degradation
- Free radicals
- Methylation
- Procyanidin B2
- Rats
- Urinary excretion
ASJC Scopus subject areas
- Medicine(all)
- Toxicology
- Clinical Biochemistry
Cite this
Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. / Baba, Seigo; Osakabe, Naomi; Natsume, Midori; Terao, Junji.
In: Free Radical Biology and Medicine, Vol. 33, No. 1, 01.07.2002, p. 142-148.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats
AU - Baba, Seigo
AU - Osakabe, Naomi
AU - Natsume, Midori
AU - Terao, Junji
PY - 2002/7/1
Y1 - 2002/7/1
N2 - We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.
AB - We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.
KW - (-)-Epicatechin
KW - Absorption
KW - Antioxidant
KW - Conjugation
KW - Degradation
KW - Free radicals
KW - Methylation
KW - Procyanidin B2
KW - Rats
KW - Urinary excretion
UR - http://www.scopus.com/inward/record.url?scp=0036628736&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036628736&partnerID=8YFLogxK
U2 - 10.1016/S0891-5849(02)00871-7
DO - 10.1016/S0891-5849(02)00871-7
M3 - Article
C2 - 12086692
AN - SCOPUS:0036628736
VL - 33
SP - 142
EP - 148
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
SN - 0891-5849
IS - 1
ER -