Abstract
We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.
| Original language | English |
|---|---|
| Pages (from-to) | 142-148 |
| Number of pages | 7 |
| Journal | Free Radical Biology and Medicine |
| Volume | 33 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2002 Jul 1 |
| Externally published | Yes |
Keywords
- (-)-Epicatechin
- Absorption
- Antioxidant
- Conjugation
- Degradation
- Free radicals
- Methylation
- Procyanidin B2
- Rats
- Urinary excretion
ASJC Scopus subject areas
- Biochemistry
- Physiology (medical)
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Cite this
Baba, S., Osakabe, N., Natsume, M., & Terao, J. (2002). Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. Free Radical Biology and Medicine, 33(1), 142-148. https://doi.org/10.1016/S0891-5849(02)00871-7