Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

Seigo Baba, Naomi Osakabe, Midori Natsume, Junji Terao

Research output: Contribution to journalArticle

186 Citations (Scopus)

Abstract

We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.

Original languageEnglish
Pages (from-to)142-148
Number of pages7
JournalFree Radical Biology and Medicine
Volume33
Issue number1
DOIs
Publication statusPublished - 2002 Jul 1
Externally publishedYes

Fingerprint

Catechin
Rats
Plasmas
Lipid Peroxides
Copper
Ions
procyanidin B2

Keywords

  • (-)-Epicatechin
  • Absorption
  • Antioxidant
  • Conjugation
  • Degradation
  • Free radicals
  • Methylation
  • Procyanidin B2
  • Rats
  • Urinary excretion

ASJC Scopus subject areas

  • Medicine(all)
  • Toxicology
  • Clinical Biochemistry

Cite this

Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. / Baba, Seigo; Osakabe, Naomi; Natsume, Midori; Terao, Junji.

In: Free Radical Biology and Medicine, Vol. 33, No. 1, 01.07.2002, p. 142-148.

Research output: Contribution to journalArticle

@article{a4b686e2fd154a9bb777aae461a4983a,
title = "Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats",
abstract = "We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.",
keywords = "(-)-Epicatechin, Absorption, Antioxidant, Conjugation, Degradation, Free radicals, Methylation, Procyanidin B2, Rats, Urinary excretion",
author = "Seigo Baba and Naomi Osakabe and Midori Natsume and Junji Terao",
year = "2002",
month = "7",
day = "1",
doi = "10.1016/S0891-5849(02)00871-7",
language = "English",
volume = "33",
pages = "142--148",
journal = "Free Radical Biology and Medicine",
issn = "0891-5849",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

AU - Baba, Seigo

AU - Osakabe, Naomi

AU - Natsume, Midori

AU - Terao, Junji

PY - 2002/7/1

Y1 - 2002/7/1

N2 - We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.

AB - We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.

KW - (-)-Epicatechin

KW - Absorption

KW - Antioxidant

KW - Conjugation

KW - Degradation

KW - Free radicals

KW - Methylation

KW - Procyanidin B2

KW - Rats

KW - Urinary excretion

UR - http://www.scopus.com/inward/record.url?scp=0036628736&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036628736&partnerID=8YFLogxK

U2 - 10.1016/S0891-5849(02)00871-7

DO - 10.1016/S0891-5849(02)00871-7

M3 - Article

C2 - 12086692

AN - SCOPUS:0036628736

VL - 33

SP - 142

EP - 148

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

IS - 1

ER -