Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

Seigo Baba; Naomi Osakabe; Midori Natsume; Junji Terao

doi:10.1016/S0891-5849(02)00871-7

Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

Seigo Baba, Naomi Osakabe, Midori Natsume, Junji Terao

Research output: Contribution to journal › Article › peer-review

197 Citations (Scopus)

Abstract

We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.

Original language	English
Pages (from-to)	142-148
Number of pages	7
Journal	Free Radical Biology and Medicine
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/S0891-5849(02)00871-7
Publication status	Published - 2002 Jul 1
Externally published	Yes

Keywords

(-)-Epicatechin
Absorption
Antioxidant
Conjugation
Degradation
Free radicals
Methylation
Procyanidin B2
Rats
Urinary excretion

ASJC Scopus subject areas

Biochemistry
Physiology (medical)

Access to Document

10.1016/S0891-5849(02)00871-7

Cite this

@article{a4b686e2fd154a9bb777aae461a4983a,

title = "Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats",

abstract = "We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.",

keywords = "(-)-Epicatechin, Absorption, Antioxidant, Conjugation, Degradation, Free radicals, Methylation, Procyanidin B2, Rats, Urinary excretion",

author = "Seigo Baba and Naomi Osakabe and Midori Natsume and Junji Terao",

year = "2002",

month = jul,

day = "1",

doi = "10.1016/S0891-5849(02)00871-7",

language = "English",

volume = "33",

pages = "142--148",

journal = "Free Radical Biology and Medicine",

issn = "0891-5849",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

AU - Baba, Seigo

AU - Osakabe, Naomi

AU - Natsume, Midori

AU - Terao, Junji

PY - 2002/7/1

Y1 - 2002/7/1

N2 - We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.

AB - We evaluated the bioavailability and plasma antioxidative activity after administration of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats. After procyanidin B2 administration, procyanidin B2 is absorbed and excreted in urine, and a portion of the PB2 is degraded to (-)-epicatechin and to the metabolized conjugated and/or methylated (-)-epicatechin internally in the rat. Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions.

KW - (-)-Epicatechin

KW - Absorption

KW - Antioxidant

KW - Conjugation

KW - Degradation

KW - Free radicals

KW - Methylation

KW - Procyanidin B2

KW - Rats

KW - Urinary excretion

UR - http://www.scopus.com/inward/record.url?scp=0036628736&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036628736&partnerID=8YFLogxK

U2 - 10.1016/S0891-5849(02)00871-7

DO - 10.1016/S0891-5849(02)00871-7

M3 - Article

C2 - 12086692

AN - SCOPUS:0036628736

VL - 33

SP - 142

EP - 148

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

IS - 1

ER -

Absorption and urinary excretion of procyanidin B2 [epicatechin-(4β-8)-epicatechin] in rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this