Age-related changes in the numbers of mammotrophs, somatotrophs and mammosomatotrophs in the anterior pituitary gland of female rats: A flow cytometric study

Tadashi Shinkai, Yoko Sakurai, Hiroshi Ooka

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Age-related changes in the numbers of mammotrophs, somatotrophs, mammosomatotrophs, and the cells of other types in the anterior pituitary of female Wistar rat were measured by flow cytometry. The mammotrophs increased with age, and the somatotrophs decreased with senescence. The mammosomatotrophs increased remarkably in senescent rats, and these cells of the rats older than 21 months were about 10 times more than those of 3, and 12-13 months old rats. This result indicates that the stability of gene expression in cell differentiation is reduced in the aging process of the anterior pituitary.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalMechanisms of Ageing and Development
Volume83
Issue number3
DOIs
Publication statusPublished - 1995 Sep 15
Externally publishedYes

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Rats
Flow cytometry
Gene expression
Aging of materials
Cells

Keywords

  • Acidophils
  • Aging
  • Flow cytometry
  • Mammosomatotroph
  • Rat

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology
  • Biochemistry
  • Developmental Neuroscience

Cite this

Age-related changes in the numbers of mammotrophs, somatotrophs and mammosomatotrophs in the anterior pituitary gland of female rats : A flow cytometric study. / Shinkai, Tadashi; Sakurai, Yoko; Ooka, Hiroshi.

In: Mechanisms of Ageing and Development, Vol. 83, No. 3, 15.09.1995, p. 125-131.

Research output: Contribution to journalArticle

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