Amino disaccharides having an alpha-(1-->4) or a beta-(1-->4) linkage, their synthesis and evaluation as a potential inhibitor for HIV-1 TAR-Tat.

Takashi Iguchi, Hirohumi Ishikawa, Hiroharu Matumoto, Mamoru Mizuno, Kohtaro Goto, Keita Hamasaki

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Amino disaccharides having an alpha-(1-->4) linkage or a beta-(1-->4) linkage have been prepared as the mimics of amino glycoside antibiotics and their inhibition for HIV-1 TAR-Tat were examined. The compound having alpha-(1-->4) linkage denotes better inhibition for TAR-Tat than that of the one having beta-(1-->4).

Original languageEnglish
Pages (from-to)169-170
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number49
Publication statusPublished - 2005


ASJC Scopus subject areas

  • Medicine(all)

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