Abstract
Neamine derivatives which have an arginine (RN), a pyrene (PCN) and both pyrene and arginine (PRN) have been prepared and their binding toward the RNA fragments derived from HIV-1 activator region, TAR and RRE RNA were examined. Among them, PRN bound either TAR RNA or RRE RNA with equivalent binding affinities as Tat and Rev peptide, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 591-594 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2001 Feb 26 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators. / Hamasaki, Keita; Ueno, Akihiko.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 4, 26.02.2001, p. 591-594.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators
AU - Hamasaki, Keita
AU - Ueno, Akihiko
PY - 2001/2/26
Y1 - 2001/2/26
N2 - Neamine derivatives which have an arginine (RN), a pyrene (PCN) and both pyrene and arginine (PRN) have been prepared and their binding toward the RNA fragments derived from HIV-1 activator region, TAR and RRE RNA were examined. Among them, PRN bound either TAR RNA or RRE RNA with equivalent binding affinities as Tat and Rev peptide, respectively.
AB - Neamine derivatives which have an arginine (RN), a pyrene (PCN) and both pyrene and arginine (PRN) have been prepared and their binding toward the RNA fragments derived from HIV-1 activator region, TAR and RRE RNA were examined. Among them, PRN bound either TAR RNA or RRE RNA with equivalent binding affinities as Tat and Rev peptide, respectively.
UR - http://www.scopus.com/inward/record.url?scp=0035952260&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035952260&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(01)00005-1
DO - 10.1016/S0960-894X(01)00005-1
M3 - Article
C2 - 11229778
AN - SCOPUS:0035952260
VL - 11
SP - 591
EP - 594
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 4
ER -