Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators

Keita Hamasaki, Akihiko Ueno

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Neamine derivatives which have an arginine (RN), a pyrene (PCN) and both pyrene and arginine (PRN) have been prepared and their binding toward the RNA fragments derived from HIV-1 activator region, TAR and RRE RNA were examined. Among them, PRN bound either TAR RNA or RRE RNA with equivalent binding affinities as Tat and Rev peptide, respectively.

Original languageEnglish
Pages (from-to)591-594
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number4
DOIs
Publication statusPublished - 2001 Feb 26
Externally publishedYes

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Aminoglycosides
RNA
Anti-Bacterial Agents
Derivatives
Arginine
Proteins
Pregnenolone Carbonitrile
neamine
pyrene

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

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