Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators

Keita Hamasaki, Akihiko Ueno

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Neamine derivatives which have an arginine (RN), a pyrene (PCN) and both pyrene and arginine (PRN) have been prepared and their binding toward the RNA fragments derived from HIV-1 activator region, TAR and RRE RNA were examined. Among them, PRN bound either TAR RNA or RRE RNA with equivalent binding affinities as Tat and Rev peptide, respectively.

Original languageEnglish
Pages (from-to)591-594
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number4
DOIs
Publication statusPublished - 2001 Feb 26
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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