TY - JOUR
T1 - Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators
AU - Hamasaki, Keita
AU - Ueno, Akihiko
N1 - Funding Information:
This study was partially funded by The Mochida Memorial Foundation for Medical and Pharmaceutical Research.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001/2/26
Y1 - 2001/2/26
N2 - Neamine derivatives which have an arginine (RN), a pyrene (PCN) and both pyrene and arginine (PRN) have been prepared and their binding toward the RNA fragments derived from HIV-1 activator region, TAR and RRE RNA were examined. Among them, PRN bound either TAR RNA or RRE RNA with equivalent binding affinities as Tat and Rev peptide, respectively.
AB - Neamine derivatives which have an arginine (RN), a pyrene (PCN) and both pyrene and arginine (PRN) have been prepared and their binding toward the RNA fragments derived from HIV-1 activator region, TAR and RRE RNA were examined. Among them, PRN bound either TAR RNA or RRE RNA with equivalent binding affinities as Tat and Rev peptide, respectively.
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U2 - 10.1016/S0960-894X(01)00005-1
DO - 10.1016/S0960-894X(01)00005-1
M3 - Article
C2 - 11229778
AN - SCOPUS:0035952260
VL - 11
SP - 591
EP - 594
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 4
ER -