Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators

Keita Hamasaki, Akihiko Ueno

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48 Citations (Scopus)


Neamine derivatives which have an arginine (RN), a pyrene (PCN) and both pyrene and arginine (PRN) have been prepared and their binding toward the RNA fragments derived from HIV-1 activator region, TAR and RRE RNA were examined. Among them, PRN bound either TAR RNA or RRE RNA with equivalent binding affinities as Tat and Rev peptide, respectively.

Original languageEnglish
Pages (from-to)591-594
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number4
Publication statusPublished - 2001 Feb 26
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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