An aminoglycoside antibiotic, neamine, and its aromatic ring-substituted derivatives as potential inhibitors for HIV-1 RRE-Rev

K. Hamasaki, M. C. Woo, A. Ueno

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The binding affinities of ten aminoglycosides with RRE IIB RNA have been determined. Neamine was found as the simplest consensus unit of aminoglycoside antibiotics that bind RRE lib RNA tightly. Various aromatic ring-substituted neamines have been prepared and their binding with RRE IIB RNA was examined. Among them, pyrene-substituted neamine has shown a submicromolar level of binding with the RNA. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)8327-8332
Number of pages6
JournalTetrahedron Letters
Volume41
Issue number43
Publication statusPublished - 2000 Oct 21
Externally publishedYes

Fingerprint

Aminoglycosides
RNA
Anti-Bacterial Agents
Derivatives
neamine

Keywords

  • Amino sugars
  • Antibiotics
  • Fluorescence
  • Nucleic acids

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

An aminoglycoside antibiotic, neamine, and its aromatic ring-substituted derivatives as potential inhibitors for HIV-1 RRE-Rev. / Hamasaki, K.; Woo, M. C.; Ueno, A.

In: Tetrahedron Letters, Vol. 41, No. 43, 21.10.2000, p. 8327-8332.

Research output: Contribution to journalArticle

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