An aminoglycoside antibiotic, neamine, and its aromatic ring-substituted derivatives as potential inhibitors for HIV-1 RRE-Rev

K. Hamasaki; M. C. Woo; A. Ueno

doi:10.1016/S0040-4039(00)01449-0

An aminoglycoside antibiotic, neamine, and its aromatic ring-substituted derivatives as potential inhibitors for HIV-1 RRE-Rev

K. Hamasaki, M. C. Woo, A. Ueno

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The binding affinities of ten aminoglycosides with RRE IIB RNA have been determined. Neamine was found as the simplest consensus unit of aminoglycoside antibiotics that bind RRE lib RNA tightly. Various aromatic ring-substituted neamines have been prepared and their binding with RRE IIB RNA was examined. Among them, pyrene-substituted neamine has shown a submicromolar level of binding with the RNA. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	8327-8332
Number of pages	6
Journal	Tetrahedron Letters
Volume	41
Issue number	43
DOIs	https://doi.org/10.1016/S0040-4039(00)01449-0
Publication status	Published - 2000 Oct 21
Externally published	Yes

Keywords

Amino sugars
Antibiotics
Fluorescence
Nucleic acids

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)01449-0

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abstract = "The binding affinities of ten aminoglycosides with RRE IIB RNA have been determined. Neamine was found as the simplest consensus unit of aminoglycoside antibiotics that bind RRE lib RNA tightly. Various aromatic ring-substituted neamines have been prepared and their binding with RRE IIB RNA was examined. Among them, pyrene-substituted neamine has shown a submicromolar level of binding with the RNA. (C) 2000 Elsevier Science Ltd.",

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author = "K. Hamasaki and Woo, {M. C.} and A. Ueno",

note = "Funding Information: This work was supported in part by The Japan Securities Scholarship Foundation and The Mochida Memorial Foundation for Medical and Pharmaceutical Science. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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AU - Hamasaki, K.

AU - Woo, M. C.

AU - Ueno, A.

N1 - Funding Information: This work was supported in part by The Japan Securities Scholarship Foundation and The Mochida Memorial Foundation for Medical and Pharmaceutical Science. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2000/10/21

Y1 - 2000/10/21

N2 - The binding affinities of ten aminoglycosides with RRE IIB RNA have been determined. Neamine was found as the simplest consensus unit of aminoglycoside antibiotics that bind RRE lib RNA tightly. Various aromatic ring-substituted neamines have been prepared and their binding with RRE IIB RNA was examined. Among them, pyrene-substituted neamine has shown a submicromolar level of binding with the RNA. (C) 2000 Elsevier Science Ltd.

AB - The binding affinities of ten aminoglycosides with RRE IIB RNA have been determined. Neamine was found as the simplest consensus unit of aminoglycoside antibiotics that bind RRE lib RNA tightly. Various aromatic ring-substituted neamines have been prepared and their binding with RRE IIB RNA was examined. Among them, pyrene-substituted neamine has shown a submicromolar level of binding with the RNA. (C) 2000 Elsevier Science Ltd.

KW - Amino sugars

KW - Antibiotics

KW - Fluorescence

KW - Nucleic acids

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 43

ER -

An aminoglycoside antibiotic, neamine, and its aromatic ring-substituted derivatives as potential inhibitors for HIV-1 RRE-Rev

Abstract

Keywords

ASJC Scopus subject areas

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