Abstract
T cell subsets of peripheral blood lymphocytes were assessed in 27 patients with ulcerative colitis by a fluorescence activated cell sorter, using monoclonal antibodies to the surface antigens of suppressor/cytotoxic (Anti-Leu-2a) and helper/inducer (Anti-Leu-3a) T cells. The population of suppressor T cells was decreased in the the lymphocyte from patients with active ulcerative colitis (8.2±3.6%,p<0.01), compared with those from normal controls (24.6±3.6%). Furthermore, the binding capacity of each lymphocytes from patients with ulcerative colitis to Anti-Leu-2a was decreased. The relationship between lymphocytophilic antibodies found in patients with ulcerative colitis and T cell subsets was examined by cell sorting on a fluorescence activated cell sorter. The lymphocytophilic antibodies were demonstrated to be mainly reactive with suppressor T cells, but also reactive with non-suppressor, non-helper T cell subsets and some populations of helper T cells. These results suggest that some other factors except lymphocytophilic antibodies may influence the decrease in suppressor T cells in patients with ulcerative colitis.
| Original language | English |
|---|---|
| Pages (from-to) | 1418-1423 |
| Number of pages | 6 |
| Journal | Nippon Shokakibyo Gakkai Zasshi |
| Volume | 79 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1982 Jan 1 |
| Externally published | Yes |
ASJC Scopus subject areas
- Gastroenterology
Cite this
Analysis of peripheral lymphocyte subsets and lymphocytophilic antibodies in ulcerative colitis defined by monoclonal antibody. / Watanabe, Mamoru; Aiso, Sadakazu; Hibi, Toshifumi; Yoshida, Takeshi; Kobayashi, Kensuke; Asakura, Hitoshi; Tsuchiya, Masaharu; Tsuru, Sumiaki.
In: Nippon Shokakibyo Gakkai Zasshi, Vol. 79, No. 7, 01.01.1982, p. 1418-1423.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Analysis of peripheral lymphocyte subsets and lymphocytophilic antibodies in ulcerative colitis defined by monoclonal antibody
AU - Watanabe, Mamoru
AU - Aiso, Sadakazu
AU - Hibi, Toshifumi
AU - Yoshida, Takeshi
AU - Kobayashi, Kensuke
AU - Asakura, Hitoshi
AU - Tsuchiya, Masaharu
AU - Tsuru, Sumiaki
PY - 1982/1/1
Y1 - 1982/1/1
N2 - T cell subsets of peripheral blood lymphocytes were assessed in 27 patients with ulcerative colitis by a fluorescence activated cell sorter, using monoclonal antibodies to the surface antigens of suppressor/cytotoxic (Anti-Leu-2a) and helper/inducer (Anti-Leu-3a) T cells. The population of suppressor T cells was decreased in the the lymphocyte from patients with active ulcerative colitis (8.2±3.6%,p<0.01), compared with those from normal controls (24.6±3.6%). Furthermore, the binding capacity of each lymphocytes from patients with ulcerative colitis to Anti-Leu-2a was decreased. The relationship between lymphocytophilic antibodies found in patients with ulcerative colitis and T cell subsets was examined by cell sorting on a fluorescence activated cell sorter. The lymphocytophilic antibodies were demonstrated to be mainly reactive with suppressor T cells, but also reactive with non-suppressor, non-helper T cell subsets and some populations of helper T cells. These results suggest that some other factors except lymphocytophilic antibodies may influence the decrease in suppressor T cells in patients with ulcerative colitis.
AB - T cell subsets of peripheral blood lymphocytes were assessed in 27 patients with ulcerative colitis by a fluorescence activated cell sorter, using monoclonal antibodies to the surface antigens of suppressor/cytotoxic (Anti-Leu-2a) and helper/inducer (Anti-Leu-3a) T cells. The population of suppressor T cells was decreased in the the lymphocyte from patients with active ulcerative colitis (8.2±3.6%,p<0.01), compared with those from normal controls (24.6±3.6%). Furthermore, the binding capacity of each lymphocytes from patients with ulcerative colitis to Anti-Leu-2a was decreased. The relationship between lymphocytophilic antibodies found in patients with ulcerative colitis and T cell subsets was examined by cell sorting on a fluorescence activated cell sorter. The lymphocytophilic antibodies were demonstrated to be mainly reactive with suppressor T cells, but also reactive with non-suppressor, non-helper T cell subsets and some populations of helper T cells. These results suggest that some other factors except lymphocytophilic antibodies may influence the decrease in suppressor T cells in patients with ulcerative colitis.
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U2 - 10.11405/nisshoshi1964.79.1418
DO - 10.11405/nisshoshi1964.79.1418
M3 - Article
C2 - 6982986
AN - SCOPUS:0020155838
VL - 79
SP - 1418
EP - 1423
JO - Japanese Journal of Gastroenterology
JF - Japanese Journal of Gastroenterology
SN - 0446-6586
IS - 7
ER -