Abstract
We have demonstrated anodic alkoxylation of lactams followed by reactions with carbon nucleophiles in a one-pot manner using 1,1,1,3,3,3- hexafluoroisopropanol (HFIP) as a solvent. In the two-step transformation, HFIP acted as a nucleophile in the presence of solid-supported bases, while it acted as an inert solvent in the absence of solidsupported bases. This enabled us to conduct anodic alkoxylation of lactams and subsequent C-C bond forming reactions without replacing the solvent.
| Original language | English |
|---|---|
| Pages (from-to) | 353-355 |
| Number of pages | 3 |
| Journal | Electrochemistry |
| Volume | 81 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2013 May |
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Keywords
- Anodic alkoxylation
- Carbon-carbon bond forming reactions
- Hfip
- Solid-supported bases
ASJC Scopus subject areas
- Electrochemistry
Cite this
Anodic alkoxylation of lactams followed by reactions with carbon nucleophiles in a one-pot manner using HFIP as a solvent. / Tajima, Toshiki; Kurihara, Hitoshi; Shimizu, Shoichi; Tateno, Hiroyuki.
In: Electrochemistry, Vol. 81, No. 5, 05.2013, p. 353-355.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Anodic alkoxylation of lactams followed by reactions with carbon nucleophiles in a one-pot manner using HFIP as a solvent
AU - Tajima, Toshiki
AU - Kurihara, Hitoshi
AU - Shimizu, Shoichi
AU - Tateno, Hiroyuki
PY - 2013/5
Y1 - 2013/5
N2 - We have demonstrated anodic alkoxylation of lactams followed by reactions with carbon nucleophiles in a one-pot manner using 1,1,1,3,3,3- hexafluoroisopropanol (HFIP) as a solvent. In the two-step transformation, HFIP acted as a nucleophile in the presence of solid-supported bases, while it acted as an inert solvent in the absence of solidsupported bases. This enabled us to conduct anodic alkoxylation of lactams and subsequent C-C bond forming reactions without replacing the solvent.
AB - We have demonstrated anodic alkoxylation of lactams followed by reactions with carbon nucleophiles in a one-pot manner using 1,1,1,3,3,3- hexafluoroisopropanol (HFIP) as a solvent. In the two-step transformation, HFIP acted as a nucleophile in the presence of solid-supported bases, while it acted as an inert solvent in the absence of solidsupported bases. This enabled us to conduct anodic alkoxylation of lactams and subsequent C-C bond forming reactions without replacing the solvent.
KW - Anodic alkoxylation
KW - Carbon-carbon bond forming reactions
KW - Hfip
KW - Solid-supported bases
UR - http://www.scopus.com/inward/record.url?scp=84878967670&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878967670&partnerID=8YFLogxK
U2 - 10.5796/electrochemistry.81.353
DO - 10.5796/electrochemistry.81.353
M3 - Article
VL - 81
SP - 353
EP - 355
JO - Electrochemistry
JF - Electrochemistry
SN - 1344-3542
IS - 5
ER -