Abstract
We have demonstrated anodic alkoxylation of lactams followed by reactions with carbon nucleophiles in a one-pot manner using 1,1,1,3,3,3- hexafluoroisopropanol (HFIP) as a solvent. In the two-step transformation, HFIP acted as a nucleophile in the presence of solid-supported bases, while it acted as an inert solvent in the absence of solidsupported bases. This enabled us to conduct anodic alkoxylation of lactams and subsequent C-C bond forming reactions without replacing the solvent.
| Original language | English |
|---|---|
| Pages (from-to) | 353-355 |
| Number of pages | 3 |
| Journal | Electrochemistry |
| Volume | 81 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2013 May 1 |
Keywords
- Anodic alkoxylation
- Carbon-carbon bond forming reactions
- Hfip
- Solid-supported bases
ASJC Scopus subject areas
- Electrochemistry
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Tajima, T., Kurihara, H., Shimizu, S., & Tateno, H. (2013). Anodic alkoxylation of lactams followed by reactions with carbon nucleophiles in a one-pot manner using HFIP as a solvent. Electrochemistry, 81(5), 353-355. https://doi.org/10.5796/electrochemistry.81.353