Anodic alkoxylation of lactams followed by reactions with carbon nucleophiles in a one-pot manner using HFIP as a solvent

Toshiki Tajima, Hitoshi Kurihara, Shoichi Shimizu, Hiroyuki Tateno

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We have demonstrated anodic alkoxylation of lactams followed by reactions with carbon nucleophiles in a one-pot manner using 1,1,1,3,3,3- hexafluoroisopropanol (HFIP) as a solvent. In the two-step transformation, HFIP acted as a nucleophile in the presence of solid-supported bases, while it acted as an inert solvent in the absence of solidsupported bases. This enabled us to conduct anodic alkoxylation of lactams and subsequent C-C bond forming reactions without replacing the solvent.

Original languageEnglish
Pages (from-to)353-355
Number of pages3
JournalElectrochemistry
Volume81
Issue number5
DOIs
Publication statusPublished - 2013 May 1

Keywords

  • Anodic alkoxylation
  • Carbon-carbon bond forming reactions
  • Hfip
  • Solid-supported bases

ASJC Scopus subject areas

  • Electrochemistry

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