TY - JOUR
T1 - Anodic alkoxylation of lactams followed by reactions with carbon nucleophiles in a one-pot manner using HFIP as a solvent
AU - Tajima, Toshiki
AU - Kurihara, Hitoshi
AU - Shimizu, Shoichi
AU - Tateno, Hiroyuki
PY - 2013/5
Y1 - 2013/5
N2 - We have demonstrated anodic alkoxylation of lactams followed by reactions with carbon nucleophiles in a one-pot manner using 1,1,1,3,3,3- hexafluoroisopropanol (HFIP) as a solvent. In the two-step transformation, HFIP acted as a nucleophile in the presence of solid-supported bases, while it acted as an inert solvent in the absence of solidsupported bases. This enabled us to conduct anodic alkoxylation of lactams and subsequent C-C bond forming reactions without replacing the solvent.
AB - We have demonstrated anodic alkoxylation of lactams followed by reactions with carbon nucleophiles in a one-pot manner using 1,1,1,3,3,3- hexafluoroisopropanol (HFIP) as a solvent. In the two-step transformation, HFIP acted as a nucleophile in the presence of solid-supported bases, while it acted as an inert solvent in the absence of solidsupported bases. This enabled us to conduct anodic alkoxylation of lactams and subsequent C-C bond forming reactions without replacing the solvent.
KW - Anodic alkoxylation
KW - Carbon-carbon bond forming reactions
KW - Hfip
KW - Solid-supported bases
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U2 - 10.5796/electrochemistry.81.353
DO - 10.5796/electrochemistry.81.353
M3 - Article
AN - SCOPUS:84878967670
VL - 81
SP - 353
EP - 355
JO - Electrochemistry
JF - Electrochemistry
SN - 1344-3542
IS - 5
ER -