Anti-colon antibody and lymphocytophilic antibody in ulcerative colitis

T. Hibi, S. Aiso, T. Yoshida, M. Watanabe, H. Asakura, S. Tsuru, M. Tsuchiya

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

The presence of anti-colon antibody in the sera from patients with ulcerative colitis was demonstrated by antibody-dependent cell-mediated cytotoxicity (ADCC) assay. In addition, the high prevalence of lymphocytophilic antibody in the sera from patients with ulcerative colitis was obtained by fluorescence activated cell sorter (FACS) analysis. This lymphocytophilic antibody was absorbed by rat colon epithelial cells. Moreover the lymphocytes from ulcerative colitis showed lower binding capacity to this antibody, but acquired higher binding capacity after 20 hr incubation at 37°C in vitro. These data suggest that ADCC may have some role in the pathogenesis of ulcerative colitis.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalClinical and Experimental Immunology
Volume49
Issue number1
Publication statusPublished - 1982 Sep 20
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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