Anti-obesity effects of Tocotrienols and bran in high-fat diet-treated mice

Koji Fukui, Masashi Shirai, Takeyuki Ninuma, Yugo Kato

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Obesity is a serious public health issue in developed countries, and is known to increase the risk of several diseases such as diabetes, cardiovascular events and arteriosclerosis. These phenomena are closely correlated with oxidative damage. Recently, several lines of evidence have demonstrated that neurodegenerative diseases such as Alzheimer’s and Parkinson’s are also related to oxidative damage. To clarify the relationship between obesity and oxidative brain injury, we investigated brain antioxidant networks in high-fat (HF) diet-treated mice in the presence or absence of tocotrienols (T3s) and bran. Co-treatment with T3s and bran significantly inhibited bodyweight gain in HF diet-treated mice. Serum and cortex T3 levels, and brain antioxidant enzyme activities and protein expressions did not differ among the groups except for SOD protein expression in the cerebellum. Brain p-mTOR and p-Akt protein expressions, which are related to autophagy, did not differ among the groups. These results indicate that treatment with T3s for eight weeks had showed an anti-obesity effect in HF diet-treated mice. However, significant alterations in T3 levels were not observed in the serum and brain of mice.

Original languageEnglish
Article number830
JournalNutrients
Volume11
Issue number4
DOIs
Publication statusPublished - 2019 Apr 1

Fingerprint

tocotrienols
bran
high fat diet
obesity
brain
mice
protein synthesis
antioxidants
autophagy
neurodegenerative diseases
cerebellum
developed countries
diabetes
public health
cortex
superoxide dismutase
enzyme activity
body weight

Keywords

  • Anti-obesity
  • Bran
  • High-fat
  • Oxidative stress
  • Tocotrienols

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Anti-obesity effects of Tocotrienols and bran in high-fat diet-treated mice. / Fukui, Koji; Shirai, Masashi; Ninuma, Takeyuki; Kato, Yugo.

In: Nutrients, Vol. 11, No. 4, 830, 01.04.2019.

Research output: Contribution to journalArticle

Fukui, Koji ; Shirai, Masashi ; Ninuma, Takeyuki ; Kato, Yugo. / Anti-obesity effects of Tocotrienols and bran in high-fat diet-treated mice. In: Nutrients. 2019 ; Vol. 11, No. 4.
@article{b10a8cf0c3b041db9e6ca2d6142661bb,
title = "Anti-obesity effects of Tocotrienols and bran in high-fat diet-treated mice",
abstract = "Obesity is a serious public health issue in developed countries, and is known to increase the risk of several diseases such as diabetes, cardiovascular events and arteriosclerosis. These phenomena are closely correlated with oxidative damage. Recently, several lines of evidence have demonstrated that neurodegenerative diseases such as Alzheimer’s and Parkinson’s are also related to oxidative damage. To clarify the relationship between obesity and oxidative brain injury, we investigated brain antioxidant networks in high-fat (HF) diet-treated mice in the presence or absence of tocotrienols (T3s) and bran. Co-treatment with T3s and bran significantly inhibited bodyweight gain in HF diet-treated mice. Serum and cortex T3 levels, and brain antioxidant enzyme activities and protein expressions did not differ among the groups except for SOD protein expression in the cerebellum. Brain p-mTOR and p-Akt protein expressions, which are related to autophagy, did not differ among the groups. These results indicate that treatment with T3s for eight weeks had showed an anti-obesity effect in HF diet-treated mice. However, significant alterations in T3 levels were not observed in the serum and brain of mice.",
keywords = "Anti-obesity, Bran, High-fat, Oxidative stress, Tocotrienols",
author = "Koji Fukui and Masashi Shirai and Takeyuki Ninuma and Yugo Kato",
year = "2019",
month = "4",
day = "1",
doi = "10.3390/nu11040830",
language = "English",
volume = "11",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",

}

TY - JOUR

T1 - Anti-obesity effects of Tocotrienols and bran in high-fat diet-treated mice

AU - Fukui, Koji

AU - Shirai, Masashi

AU - Ninuma, Takeyuki

AU - Kato, Yugo

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Obesity is a serious public health issue in developed countries, and is known to increase the risk of several diseases such as diabetes, cardiovascular events and arteriosclerosis. These phenomena are closely correlated with oxidative damage. Recently, several lines of evidence have demonstrated that neurodegenerative diseases such as Alzheimer’s and Parkinson’s are also related to oxidative damage. To clarify the relationship between obesity and oxidative brain injury, we investigated brain antioxidant networks in high-fat (HF) diet-treated mice in the presence or absence of tocotrienols (T3s) and bran. Co-treatment with T3s and bran significantly inhibited bodyweight gain in HF diet-treated mice. Serum and cortex T3 levels, and brain antioxidant enzyme activities and protein expressions did not differ among the groups except for SOD protein expression in the cerebellum. Brain p-mTOR and p-Akt protein expressions, which are related to autophagy, did not differ among the groups. These results indicate that treatment with T3s for eight weeks had showed an anti-obesity effect in HF diet-treated mice. However, significant alterations in T3 levels were not observed in the serum and brain of mice.

AB - Obesity is a serious public health issue in developed countries, and is known to increase the risk of several diseases such as diabetes, cardiovascular events and arteriosclerosis. These phenomena are closely correlated with oxidative damage. Recently, several lines of evidence have demonstrated that neurodegenerative diseases such as Alzheimer’s and Parkinson’s are also related to oxidative damage. To clarify the relationship between obesity and oxidative brain injury, we investigated brain antioxidant networks in high-fat (HF) diet-treated mice in the presence or absence of tocotrienols (T3s) and bran. Co-treatment with T3s and bran significantly inhibited bodyweight gain in HF diet-treated mice. Serum and cortex T3 levels, and brain antioxidant enzyme activities and protein expressions did not differ among the groups except for SOD protein expression in the cerebellum. Brain p-mTOR and p-Akt protein expressions, which are related to autophagy, did not differ among the groups. These results indicate that treatment with T3s for eight weeks had showed an anti-obesity effect in HF diet-treated mice. However, significant alterations in T3 levels were not observed in the serum and brain of mice.

KW - Anti-obesity

KW - Bran

KW - High-fat

KW - Oxidative stress

KW - Tocotrienols

UR - http://www.scopus.com/inward/record.url?scp=85065316620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065316620&partnerID=8YFLogxK

U2 - 10.3390/nu11040830

DO - 10.3390/nu11040830

M3 - Article

VL - 11

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 4

M1 - 830

ER -