Application of radical chain reactions to drug release controlling of liposomal carriers under high magnetic fields

Hidenori Nakagawa; Shoogo Ueno; Tsuyoshi Shiina; Makoto Kotani; Shunichiro Kubota

doi:10.1063/1.3076894

Application of radical chain reactions to drug release controlling of liposomal carriers under high magnetic fields

Hidenori Nakagawa, Shoogo Ueno, Tsuyoshi Shiina, Makoto Kotani, Shunichiro Kubota

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The use of paramagnetic liposomes modified with radical initiators is a new approach for applications to drug delivery systems. In order to evaluate the potentials of these liposomes, we investigated the effect of 2, 2′ -azobis(2,4-dimethylvaleronitrile) as a radical initiator on the fluidity and permeability of model membranes, using NMR spectroscopy. The results are discussed in terms of the number of unsaturated double bonds in phospholipids of liposomal membranes.

Original language	English
Article number	07B323
Journal	Journal of Applied Physics
Volume	105
Issue number	7
DOIs	https://doi.org/10.1063/1.3076894
Publication status	Published - 2009
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy(all)

Access to Document

10.1063/1.3076894

Cite this

@article{efd25dff42b34b9294de1fa6548a3c83,

title = "Application of radical chain reactions to drug release controlling of liposomal carriers under high magnetic fields",

abstract = "The use of paramagnetic liposomes modified with radical initiators is a new approach for applications to drug delivery systems. In order to evaluate the potentials of these liposomes, we investigated the effect of 2, 2′ -azobis(2,4-dimethylvaleronitrile) as a radical initiator on the fluidity and permeability of model membranes, using NMR spectroscopy. The results are discussed in terms of the number of unsaturated double bonds in phospholipids of liposomal membranes.",

author = "Hidenori Nakagawa and Shoogo Ueno and Tsuyoshi Shiina and Makoto Kotani and Shunichiro Kubota",

note = "Funding Information: The authors are indebted to Dr. Furihata, the University of Tokyo, for valuable advice on NMR measurements. This work was supported in part by grants from the Magnetic Health Science Foundation and a Grant-in-Aid for Scientific Research (S) (No. 17100006) from the Japan Society for the Promotion of Science (JSPS).",

year = "2009",

doi = "10.1063/1.3076894",

language = "English",

volume = "105",

journal = "Journal of Applied Physics",

issn = "0021-8979",

publisher = "American Institute of Physics Publising LLC",

number = "7",

}

TY - JOUR

T1 - Application of radical chain reactions to drug release controlling of liposomal carriers under high magnetic fields

AU - Nakagawa, Hidenori

AU - Ueno, Shoogo

AU - Shiina, Tsuyoshi

AU - Kotani, Makoto

AU - Kubota, Shunichiro

N1 - Funding Information: The authors are indebted to Dr. Furihata, the University of Tokyo, for valuable advice on NMR measurements. This work was supported in part by grants from the Magnetic Health Science Foundation and a Grant-in-Aid for Scientific Research (S) (No. 17100006) from the Japan Society for the Promotion of Science (JSPS).

PY - 2009

Y1 - 2009

N2 - The use of paramagnetic liposomes modified with radical initiators is a new approach for applications to drug delivery systems. In order to evaluate the potentials of these liposomes, we investigated the effect of 2, 2′ -azobis(2,4-dimethylvaleronitrile) as a radical initiator on the fluidity and permeability of model membranes, using NMR spectroscopy. The results are discussed in terms of the number of unsaturated double bonds in phospholipids of liposomal membranes.

AB - The use of paramagnetic liposomes modified with radical initiators is a new approach for applications to drug delivery systems. In order to evaluate the potentials of these liposomes, we investigated the effect of 2, 2′ -azobis(2,4-dimethylvaleronitrile) as a radical initiator on the fluidity and permeability of model membranes, using NMR spectroscopy. The results are discussed in terms of the number of unsaturated double bonds in phospholipids of liposomal membranes.

UR - http://www.scopus.com/inward/record.url?scp=65249151783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65249151783&partnerID=8YFLogxK

U2 - 10.1063/1.3076894

DO - 10.1063/1.3076894

M3 - Article

AN - SCOPUS:65249151783

SN - 0021-8979

VL - 105

JO - Journal of Applied Physics

JF - Journal of Applied Physics

IS - 7

M1 - 07B323

ER -

Application of radical chain reactions to drug release controlling of liposomal carriers under high magnetic fields

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this