Approaches to understanding adaptations of skin color variation by detecting gene-environment interactions

Sumiko Anno, Kazuhiko Ohshima, Takashi Abe

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Genetic and environmental factors are both part of an elaborate feedback mechanism whereby the human adaptive form reacts to environmental stimuli via internal adjustments. Human survival may ultimately depend on understanding two important components of future environmental adaptation. First, we must elucidate the dynamics of the human genome underpinning the complex human phenotype. Second, we must understand how the environment pressures and affects the genome, helping to determine human traits. This article reviews current approaches to detecting the natural selection of skin color variation in human populations. We include statistical methods for clarifying gene-environment interactions applicable to the interactions with UV radiation levels. We recommend spatial data mining as an efficient approach that applies environmental association rules, extending our knowledge of adaptation to the environment.

Original languageEnglish
Pages (from-to)987-991
Number of pages5
JournalExpert Review of Molecular Diagnostics
Volume10
Issue number8
DOIs
Publication statusPublished - 2010 Nov 1

Keywords

  • UV radiation levels
  • adaptation
  • environmental association rules
  • gene-environment interactions
  • genetic evolutionary history
  • natural selection
  • skin color variation
  • spatial data mining

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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