Arsenic level in toenails is associated with hearing loss in humans

Xiang Li, Nobutaka Ohgami, Ichiro Yajima, Huadong Xu, Machiko Iida, Reina Oshino, Hiromasa Ninomiya, Dandan Shen, Nazmul Ahsan, Anwarul Azim Akhand, Masashi Kato

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Arsenic (As) pollution in drinking water is a worldwide health risk for humans. We previously showed hearing loss in young people who live in areas of As-polluted drinking water and in young mice orally treated with As. In this study, we epidemiologically examined associations between As levels in toenails and hearing in 145 Bangladeshi aged 12–55 years in 2014. Levels of As in toenails, but not those in urine, were shown to be significantly correlated with hearing loss at 4 kHz [odds ratio (OR) = 4.27; 95% confidence interval (CI): 1.51, 12.05], 8 kHz (OR = 3.91; 95% CI: 1.47, 10.38) and 12 kHz (OR = 4.15; 95% CI: 1.55, 11.09) by multivariate analysis with adjustments for age, sex, smoking and BMI. Our experimental study further showed a significant association between As levels in inner ears and nails (r = 0.8113, p = 0.0014) in mice orally exposed to As, suggesting that As level in nails is a suitable index to assess As level in inner ears. Taken together, the results of our study suggest that As level in nails could be a convenient and non-invasive biomarker for As-mediated hearing loss in humans.

Original languageEnglish
Article numbere0198743
JournalPLoS ONE
Volume13
Issue number7
DOIs
Publication statusPublished - 2018 Jul 1
Externally publishedYes

Fingerprint

Audition
Arsenic
hearing
arsenic
Nails
odds ratio
confidence interval
Drinking Water
drinking water
ears
Health risks
mice
Biomarkers
multivariate analysis
biomarkers
Pollution
urine
pollution
Association reactions

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Li, X., Ohgami, N., Yajima, I., Xu, H., Iida, M., Oshino, R., ... Kato, M. (2018). Arsenic level in toenails is associated with hearing loss in humans. PLoS ONE, 13(7), [e0198743]. https://doi.org/10.1371/journal.pone.0198743

Arsenic level in toenails is associated with hearing loss in humans. / Li, Xiang; Ohgami, Nobutaka; Yajima, Ichiro; Xu, Huadong; Iida, Machiko; Oshino, Reina; Ninomiya, Hiromasa; Shen, Dandan; Ahsan, Nazmul; Akhand, Anwarul Azim; Kato, Masashi.

In: PLoS ONE, Vol. 13, No. 7, e0198743, 01.07.2018.

Research output: Contribution to journalArticle

Li, X, Ohgami, N, Yajima, I, Xu, H, Iida, M, Oshino, R, Ninomiya, H, Shen, D, Ahsan, N, Akhand, AA & Kato, M 2018, 'Arsenic level in toenails is associated with hearing loss in humans', PLoS ONE, vol. 13, no. 7, e0198743. https://doi.org/10.1371/journal.pone.0198743
Li, Xiang ; Ohgami, Nobutaka ; Yajima, Ichiro ; Xu, Huadong ; Iida, Machiko ; Oshino, Reina ; Ninomiya, Hiromasa ; Shen, Dandan ; Ahsan, Nazmul ; Akhand, Anwarul Azim ; Kato, Masashi. / Arsenic level in toenails is associated with hearing loss in humans. In: PLoS ONE. 2018 ; Vol. 13, No. 7.
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