Biomechanical analysis of an aortic aneurysm model and its clinical application to thoracic aortic aneurysms for defining "saccular" aneurysms

Takafumi Akai, Katsuyuki Hoshina, Sota Yamamoto, Hiroaki Takeuchi, Youkou Nemoto, Marie Ohshima, Kunihiro Shigematsu, Tetsuro Miyata, Haruo Yamauchi, Minoru Ono, Toshiaki Watanabe

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND: We aimed to develop a simple structural model of aortic aneurysms using computer-assisted drafting (CAD) in order to create a basis of definition for saccular aortic aneurysms.

METHODS AND RESULTS: We constructed a simple aortic aneurysm model with 2 components: a tube similar to an aorta and an ellipse analogous to a bulging aneurysm. Three parameters, including the vertical and horizontal diameters of the ellipse and the fillet radius, were altered in the model. Using structural analysis with the finite element method, we visualized the distribution of the maximum principal stress (MPS) in the aortic wall and identified the area(s) of prominent stress. We then selected patients with thoracic aortic aneurysms in whom the aneurysm expansion rates were followed up and applied the theoretical results to the raw imaging data. The maximum MPS drastically increased at areas where the aspect ratio (vertical/horizontal) was <1, indicating that "horizontally long" hypothetical ellipses should be defined as "saccular" aneurysms. The aneurysm expansion rate for the patients with thoracic aneurysms conforming to these parameters was significantly high. Further, "vertically long" ellipses with a small fillet might be candidates for saccular aneurysms; however, the clinical data did not support this.

CONCLUSIONS: Based on the biomechanical analysis of a simple aneurysm model and the clinical data of the thoracic aortic aneurysms, we defined "horizontally long" aortic aneurysms with an aspect ratio of <1 as "saccular" aneurysms.

Original languageEnglish
Pages (from-to)e001547
JournalJournal of the American Heart Association
Volume4
Issue number1
DOIs
Publication statusPublished - 2015 Jan 19
Externally publishedYes

Keywords

  • aortic aneurysm
  • principal stress
  • saccular

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Biomechanical analysis of an aortic aneurysm model and its clinical application to thoracic aortic aneurysms for defining "saccular" aneurysms. / Akai, Takafumi; Hoshina, Katsuyuki; Yamamoto, Sota; Takeuchi, Hiroaki; Nemoto, Youkou; Ohshima, Marie; Shigematsu, Kunihiro; Miyata, Tetsuro; Yamauchi, Haruo; Ono, Minoru; Watanabe, Toshiaki.

In: Journal of the American Heart Association, Vol. 4, No. 1, 19.01.2015, p. e001547.

Research output: Contribution to journalArticle

Akai, T, Hoshina, K, Yamamoto, S, Takeuchi, H, Nemoto, Y, Ohshima, M, Shigematsu, K, Miyata, T, Yamauchi, H, Ono, M & Watanabe, T 2015, 'Biomechanical analysis of an aortic aneurysm model and its clinical application to thoracic aortic aneurysms for defining "saccular" aneurysms', Journal of the American Heart Association, vol. 4, no. 1, pp. e001547. https://doi.org/10.1161/JAHA.114.001547
Akai, Takafumi ; Hoshina, Katsuyuki ; Yamamoto, Sota ; Takeuchi, Hiroaki ; Nemoto, Youkou ; Ohshima, Marie ; Shigematsu, Kunihiro ; Miyata, Tetsuro ; Yamauchi, Haruo ; Ono, Minoru ; Watanabe, Toshiaki. / Biomechanical analysis of an aortic aneurysm model and its clinical application to thoracic aortic aneurysms for defining "saccular" aneurysms. In: Journal of the American Heart Association. 2015 ; Vol. 4, No. 1. pp. e001547.
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AU - Takeuchi, Hiroaki

AU - Nemoto, Youkou

AU - Ohshima, Marie

AU - Shigematsu, Kunihiro

AU - Miyata, Tetsuro

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AU - Ono, Minoru

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AB - BACKGROUND: We aimed to develop a simple structural model of aortic aneurysms using computer-assisted drafting (CAD) in order to create a basis of definition for saccular aortic aneurysms.METHODS AND RESULTS: We constructed a simple aortic aneurysm model with 2 components: a tube similar to an aorta and an ellipse analogous to a bulging aneurysm. Three parameters, including the vertical and horizontal diameters of the ellipse and the fillet radius, were altered in the model. Using structural analysis with the finite element method, we visualized the distribution of the maximum principal stress (MPS) in the aortic wall and identified the area(s) of prominent stress. We then selected patients with thoracic aortic aneurysms in whom the aneurysm expansion rates were followed up and applied the theoretical results to the raw imaging data. The maximum MPS drastically increased at areas where the aspect ratio (vertical/horizontal) was <1, indicating that "horizontally long" hypothetical ellipses should be defined as "saccular" aneurysms. The aneurysm expansion rate for the patients with thoracic aneurysms conforming to these parameters was significantly high. Further, "vertically long" ellipses with a small fillet might be candidates for saccular aneurysms; however, the clinical data did not support this.CONCLUSIONS: Based on the biomechanical analysis of a simple aneurysm model and the clinical data of the thoracic aortic aneurysms, we defined "horizontally long" aortic aneurysms with an aspect ratio of <1 as "saccular" aneurysms.

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