Blood-device interaction

Michael J. Simmonds, Nobuo Watanabe, Deepika Nandakumar, Jarod Horobin

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)


Management of organ failure has improved in recent years in parallel with advancements in interventions, including organ transplant, although the shortage of donor organs remains the rate-limiting step. The advent of mechanical alternatives to biological organs is a burgeoning area available to clinicians in a variety of scenarios, including short-term procedures (e.g., cardiopulmonary bypass), longer and acute management (e.g., extracorporeal membrane oxygenation), and semi-to-permanent therapies (e.g., ventricular assist devices). A paradigm shift has recently effected a transition from "bridge" therapies toward destination therapies, with a resultant increase in clinical utilization. It is clear, however, that while mechanical circulatory and respiratory support devices can sustain life, damage to blood and its constituents, and/or activation of cellular processes, can negatively impact recovery and health. These adverse effects may be broadly related to blood exposure to high shear stress and/or interactions between biological and artificial materials. Only through advances in mechanical circulatory and respiratory support to minimize blood damage will complications be overcome and mechanical devices attain their true potential.

Original languageEnglish
Title of host publicationMechanical Circulatory and Respiratory Support
PublisherElsevier Inc.
Number of pages30
ISBN (Electronic)9780128104927
ISBN (Print)9780128104910
Publication statusPublished - 2018


  • Blood compatibility
  • Blood damage
  • Blood rheology
  • Erythrocytes
  • Platelets

ASJC Scopus subject areas

  • Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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