Abstract
Lodging of cardiovascular gas bubbles is investigated in a microfluidic model of small arteriole bifurcations. These experiments address the dynamics of the lodging mechanism of gas bubbles in bifurcations. This work is motivated by a novel gas embolotherapy technique for the potential treatment of cancer by tumor infarction. The experimental model arteriole bifurcations were constructed from a transparent elastomer (polydimethylsiloxane). A single air bubble was suspended in water within the parent tube of the bifurcation and a specified driving pressure was imposed via constant elevation reservoirs that were open to atmospheric pressure. The driving pressure and bubble size were varied, and their effects on the bubble lodging were assessed. The results show that the pressure to lodge a bubble in a bifurcation is less than to dislodge it. It was also possible to occlude an entire bifurcation and multiple bifurcation devices with bubbles. Splitting ratios were assessed in the range of lodging to dislodging pressure where we observed an instability in bubble splitting. From the results we estimate that gas bubbles from embolotherapy can lodge in vessels 21 μm or smaller in diameter. These findings may be useful in developing strategies for microbubble delivery in gas embolotherapy.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of 2006 International Conference on Microtechnologies in Medicine and Biology |
| Pages | 202-205 |
| Number of pages | 4 |
| DOIs | |
| Publication status | Published - 2006 |
| Externally published | Yes |
| Event | 2006 International Conference on Microtechnologies in Medicine and Biology - Okinawa Duration: 2006 May 9 → 2006 May 12 |
Other
| Other | 2006 International Conference on Microtechnologies in Medicine and Biology |
|---|---|
| City | Okinawa |
| Period | 06/5/9 → 06/5/12 |
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Keywords
- Bubbles
- Gas embolotherapy
- Microchannels
- Microvessel and bifurcating channels
ASJC Scopus subject areas
- Biomedical Engineering
- Electrical and Electronic Engineering
- Medicine(all)
Cite this
Bubble lodging in bifurcating microvessel networks : A microfluidic model. / Calderón, Andrés J.; Heo, Yunseok; Huh, Dongeun; Futai, Nobuyuki; Takayama, Shuichi; Fowlkes, J. Brian; Bull, Joseph L.
Proceedings of 2006 International Conference on Microtechnologies in Medicine and Biology. 2006. p. 202-205 4281346.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Bubble lodging in bifurcating microvessel networks
T2 - A microfluidic model
AU - Calderón, Andrés J.
AU - Heo, Yunseok
AU - Huh, Dongeun
AU - Futai, Nobuyuki
AU - Takayama, Shuichi
AU - Fowlkes, J. Brian
AU - Bull, Joseph L.
PY - 2006
Y1 - 2006
N2 - Lodging of cardiovascular gas bubbles is investigated in a microfluidic model of small arteriole bifurcations. These experiments address the dynamics of the lodging mechanism of gas bubbles in bifurcations. This work is motivated by a novel gas embolotherapy technique for the potential treatment of cancer by tumor infarction. The experimental model arteriole bifurcations were constructed from a transparent elastomer (polydimethylsiloxane). A single air bubble was suspended in water within the parent tube of the bifurcation and a specified driving pressure was imposed via constant elevation reservoirs that were open to atmospheric pressure. The driving pressure and bubble size were varied, and their effects on the bubble lodging were assessed. The results show that the pressure to lodge a bubble in a bifurcation is less than to dislodge it. It was also possible to occlude an entire bifurcation and multiple bifurcation devices with bubbles. Splitting ratios were assessed in the range of lodging to dislodging pressure where we observed an instability in bubble splitting. From the results we estimate that gas bubbles from embolotherapy can lodge in vessels 21 μm or smaller in diameter. These findings may be useful in developing strategies for microbubble delivery in gas embolotherapy.
AB - Lodging of cardiovascular gas bubbles is investigated in a microfluidic model of small arteriole bifurcations. These experiments address the dynamics of the lodging mechanism of gas bubbles in bifurcations. This work is motivated by a novel gas embolotherapy technique for the potential treatment of cancer by tumor infarction. The experimental model arteriole bifurcations were constructed from a transparent elastomer (polydimethylsiloxane). A single air bubble was suspended in water within the parent tube of the bifurcation and a specified driving pressure was imposed via constant elevation reservoirs that were open to atmospheric pressure. The driving pressure and bubble size were varied, and their effects on the bubble lodging were assessed. The results show that the pressure to lodge a bubble in a bifurcation is less than to dislodge it. It was also possible to occlude an entire bifurcation and multiple bifurcation devices with bubbles. Splitting ratios were assessed in the range of lodging to dislodging pressure where we observed an instability in bubble splitting. From the results we estimate that gas bubbles from embolotherapy can lodge in vessels 21 μm or smaller in diameter. These findings may be useful in developing strategies for microbubble delivery in gas embolotherapy.
KW - Bubbles
KW - Gas embolotherapy
KW - Microchannels
KW - Microvessel and bifurcating channels
UR - http://www.scopus.com/inward/record.url?scp=35548950411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35548950411&partnerID=8YFLogxK
U2 - 10.1109/MMB.2006.251528
DO - 10.1109/MMB.2006.251528
M3 - Conference contribution
AN - SCOPUS:35548950411
SN - 1424403383
SN - 9781424403387
SP - 202
EP - 205
BT - Proceedings of 2006 International Conference on Microtechnologies in Medicine and Biology
ER -