C-Ret-mediated hearing losses

Nobutaka Ohgami, Haruka Tamura, Kyoko Ohgami, Machiko Iida, Ichiro Yajima, Mayuko Y. Kumasaka, Yuji Goto, Michihiko Sone, Tsutomu Nakashima, Masashi Kato

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

About 120 million people worldwide suffer from congenital (early-onset) hearing loss. Thirty percent of them have syndromic hearing loss and the remaining 70% have non-syndromic hearing loss. In addition, a large number of elderly people worldwide suffer from age-related (late-onset) hearing loss. c-Ret and c-RET have been shown to be essential for the development and maintenance of neurons including the enteric nervous system (ENS) in mice and humans. Impairments of endothelin receptor B (EDNRB) and SOX10 have been shown to cause a significantly increased risk of dominant sensorineural deafness in Hirschsprung disease (HSCR) patients. We have recently shown that impairments of tyrosine 1062 (Y1062) phosphorylation in c-Ret causes syndromic congenital deafness in mice and humans and non-syndromic age-related hearing loss with neurodegeneration of spiral ganglion neurons (SGNs) in mice. This review focuses on the pathogenesis of hearing loss caused by impairments of c-Ret.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalInternational Journal of Clinical and Experimental Pathology
Volume5
Issue number1
Publication statusPublished - 2012 Feb 13
Externally publishedYes

Keywords

  • Age-related deafness
  • C-Ret
  • Congenital deafness
  • Neurodegeneration
  • Spiral ganglion neuron
  • Tyrosine kinase

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Ohgami, N., Tamura, H., Ohgami, K., Iida, M., Yajima, I., Kumasaka, M. Y., ... Kato, M. (2012). C-Ret-mediated hearing losses. International Journal of Clinical and Experimental Pathology, 5(1), 23-28.

C-Ret-mediated hearing losses. / Ohgami, Nobutaka; Tamura, Haruka; Ohgami, Kyoko; Iida, Machiko; Yajima, Ichiro; Kumasaka, Mayuko Y.; Goto, Yuji; Sone, Michihiko; Nakashima, Tsutomu; Kato, Masashi.

In: International Journal of Clinical and Experimental Pathology, Vol. 5, No. 1, 13.02.2012, p. 23-28.

Research output: Contribution to journalReview article

Ohgami, N, Tamura, H, Ohgami, K, Iida, M, Yajima, I, Kumasaka, MY, Goto, Y, Sone, M, Nakashima, T & Kato, M 2012, 'C-Ret-mediated hearing losses', International Journal of Clinical and Experimental Pathology, vol. 5, no. 1, pp. 23-28.
Ohgami N, Tamura H, Ohgami K, Iida M, Yajima I, Kumasaka MY et al. C-Ret-mediated hearing losses. International Journal of Clinical and Experimental Pathology. 2012 Feb 13;5(1):23-28.
Ohgami, Nobutaka ; Tamura, Haruka ; Ohgami, Kyoko ; Iida, Machiko ; Yajima, Ichiro ; Kumasaka, Mayuko Y. ; Goto, Yuji ; Sone, Michihiko ; Nakashima, Tsutomu ; Kato, Masashi. / C-Ret-mediated hearing losses. In: International Journal of Clinical and Experimental Pathology. 2012 ; Vol. 5, No. 1. pp. 23-28.
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