Cacao liquor polyphenols reduce oxidative stress without maintaining α-tocopherol levels in rats fed a vitamin E-deficient diet

Megumi Yamagishi, Naomi Osakabe, Toshio Takizawa, Toshihiko Osawa

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The effect of crude polyphenols (CLP) from cacao liquor on vitamin E-deficient rats was examined. The CLP fraction contained 49.8% antioxidative polyphenols such as catechins and their oligomers. Supplementation of the vitamin E-deficient diet with CLP for 7 wk did not prevent the decrease in α-tocopherol levels in the liver, kidney, heart, brain, and plasma. The lipid peroxide levels in these tissues increased in the group fed the vitamin E-deficient diet compared with the control group. However, these changes were inhibited in a dose-dependent manner as a result of supplementation of the vitamin E-deficient diet with 0.25, 0.5, or 1.0% CLP. The lipid peroxide levels in plasma increased in the group fed the vitamin E-deficient diet. This change tended to be suppressed as a result of supplementation of the diet with CLP, but the difference was not significant. There was no evidence of absorption and distribution of CLP to the tissues; however, CLP intake resulted in a decrease in oxidative stress without maintaining vitamin E levels in the plasma and the tissues.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalLipids
Volume36
Issue number1
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

chocolate liquor
Oxidative stress
Tocopherols
Polyphenols
Nutrition
Vitamin E
tocopherols
vitamin E
Rats
polyphenols
oxidative stress
rats
diet
Lipid Peroxides
Tissue
peroxides
Plasmas
Catechin
flavanols
lipids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science
  • Biochemistry

Cite this

Cacao liquor polyphenols reduce oxidative stress without maintaining α-tocopherol levels in rats fed a vitamin E-deficient diet. / Yamagishi, Megumi; Osakabe, Naomi; Takizawa, Toshio; Osawa, Toshihiko.

In: Lipids, Vol. 36, No. 1, 2001, p. 67-71.

Research output: Contribution to journalArticle

@article{28618796784049f4a34b791315864de1,
title = "Cacao liquor polyphenols reduce oxidative stress without maintaining α-tocopherol levels in rats fed a vitamin E-deficient diet",
abstract = "The effect of crude polyphenols (CLP) from cacao liquor on vitamin E-deficient rats was examined. The CLP fraction contained 49.8{\%} antioxidative polyphenols such as catechins and their oligomers. Supplementation of the vitamin E-deficient diet with CLP for 7 wk did not prevent the decrease in α-tocopherol levels in the liver, kidney, heart, brain, and plasma. The lipid peroxide levels in these tissues increased in the group fed the vitamin E-deficient diet compared with the control group. However, these changes were inhibited in a dose-dependent manner as a result of supplementation of the vitamin E-deficient diet with 0.25, 0.5, or 1.0{\%} CLP. The lipid peroxide levels in plasma increased in the group fed the vitamin E-deficient diet. This change tended to be suppressed as a result of supplementation of the diet with CLP, but the difference was not significant. There was no evidence of absorption and distribution of CLP to the tissues; however, CLP intake resulted in a decrease in oxidative stress without maintaining vitamin E levels in the plasma and the tissues.",
author = "Megumi Yamagishi and Naomi Osakabe and Toshio Takizawa and Toshihiko Osawa",
year = "2001",
language = "English",
volume = "36",
pages = "67--71",
journal = "Lipids",
issn = "0024-4201",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Cacao liquor polyphenols reduce oxidative stress without maintaining α-tocopherol levels in rats fed a vitamin E-deficient diet

AU - Yamagishi, Megumi

AU - Osakabe, Naomi

AU - Takizawa, Toshio

AU - Osawa, Toshihiko

PY - 2001

Y1 - 2001

N2 - The effect of crude polyphenols (CLP) from cacao liquor on vitamin E-deficient rats was examined. The CLP fraction contained 49.8% antioxidative polyphenols such as catechins and their oligomers. Supplementation of the vitamin E-deficient diet with CLP for 7 wk did not prevent the decrease in α-tocopherol levels in the liver, kidney, heart, brain, and plasma. The lipid peroxide levels in these tissues increased in the group fed the vitamin E-deficient diet compared with the control group. However, these changes were inhibited in a dose-dependent manner as a result of supplementation of the vitamin E-deficient diet with 0.25, 0.5, or 1.0% CLP. The lipid peroxide levels in plasma increased in the group fed the vitamin E-deficient diet. This change tended to be suppressed as a result of supplementation of the diet with CLP, but the difference was not significant. There was no evidence of absorption and distribution of CLP to the tissues; however, CLP intake resulted in a decrease in oxidative stress without maintaining vitamin E levels in the plasma and the tissues.

AB - The effect of crude polyphenols (CLP) from cacao liquor on vitamin E-deficient rats was examined. The CLP fraction contained 49.8% antioxidative polyphenols such as catechins and their oligomers. Supplementation of the vitamin E-deficient diet with CLP for 7 wk did not prevent the decrease in α-tocopherol levels in the liver, kidney, heart, brain, and plasma. The lipid peroxide levels in these tissues increased in the group fed the vitamin E-deficient diet compared with the control group. However, these changes were inhibited in a dose-dependent manner as a result of supplementation of the vitamin E-deficient diet with 0.25, 0.5, or 1.0% CLP. The lipid peroxide levels in plasma increased in the group fed the vitamin E-deficient diet. This change tended to be suppressed as a result of supplementation of the diet with CLP, but the difference was not significant. There was no evidence of absorption and distribution of CLP to the tissues; however, CLP intake resulted in a decrease in oxidative stress without maintaining vitamin E levels in the plasma and the tissues.

UR - http://www.scopus.com/inward/record.url?scp=0035110089&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035110089&partnerID=8YFLogxK

M3 - Article

C2 - 11214731

AN - SCOPUS:0035110089

VL - 36

SP - 67

EP - 71

JO - Lipids

JF - Lipids

SN - 0024-4201

IS - 1

ER -