Cacao polyphenols and atherosclerosis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cacao polyphenols, catechins and procyanidins have attracted interest because of their possible effect on cardiovascular health. This paper provides an overview of our research on the effects of cocoa polyphenols on low-density lipoprotein (LDL) oxidizability and atherosclerosis. Polyphenol rich cocoa ingestion prolonged lag time (an index of LDL oxidative susceptibility) and decreased plasma oxidized LDL levels in humans and prevented atherosclerotic lesion formation in experimental animals. Catechins in cocoa show high bioavailability, and approximately 25-30% of ingested catechins are detectable in urine. After oral supplementation, they are present in blood as metabolites such as glucuronides and/or sulfate conjugated and/or methylated forms. The catechin metabolites (glucuronides) of rats and humans are structurally completely different, and their antioxidative activity is relatively maintained in rats but not in humans. On the other hand, ingestion of cacao products increased the level of HDL. The up-regulation of HDL might be shown antioxidative effect. Thus, cacao polyphenols may reduce cardiovascular disease risk.

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalJournal of Clinical Biochemistry and Nutrition
Volume37
Issue number3
DOIs
Publication statusPublished - 2005
Externally publishedYes

Fingerprint

Catechin
Cocoa
Polyphenols
atherosclerosis
polyphenols
low density lipoprotein
flavanols
Glucuronides
Metabolites
LDL Lipoproteins
Rats
cocoa products
ingestion
metabolites
Proanthocyanidins
procyanidins
rats
catechin
lesions (animal)
cardiovascular diseases

Keywords

  • Atherosclerosis
  • Cacao polyphenols
  • Catechins
  • LDL

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Cacao polyphenols and atherosclerosis. / Osakabe, Naomi.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 37, No. 3, 2005, p. 67-72.

Research output: Contribution to journalArticle

@article{03b6842db18d4d76a6d12f0221ee616f,
title = "Cacao polyphenols and atherosclerosis",
abstract = "Cacao polyphenols, catechins and procyanidins have attracted interest because of their possible effect on cardiovascular health. This paper provides an overview of our research on the effects of cocoa polyphenols on low-density lipoprotein (LDL) oxidizability and atherosclerosis. Polyphenol rich cocoa ingestion prolonged lag time (an index of LDL oxidative susceptibility) and decreased plasma oxidized LDL levels in humans and prevented atherosclerotic lesion formation in experimental animals. Catechins in cocoa show high bioavailability, and approximately 25-30{\%} of ingested catechins are detectable in urine. After oral supplementation, they are present in blood as metabolites such as glucuronides and/or sulfate conjugated and/or methylated forms. The catechin metabolites (glucuronides) of rats and humans are structurally completely different, and their antioxidative activity is relatively maintained in rats but not in humans. On the other hand, ingestion of cacao products increased the level of HDL. The up-regulation of HDL might be shown antioxidative effect. Thus, cacao polyphenols may reduce cardiovascular disease risk.",
keywords = "Atherosclerosis, Cacao polyphenols, Catechins, LDL",
author = "Naomi Osakabe",
year = "2005",
doi = "10.3164/jcbn.37.67",
language = "English",
volume = "37",
pages = "67--72",
journal = "Journal of Clinical Biochemistry and Nutrition",
issn = "0912-0009",
publisher = "The Society for Free Radical Research Japan",
number = "3",

}

TY - JOUR

T1 - Cacao polyphenols and atherosclerosis

AU - Osakabe, Naomi

PY - 2005

Y1 - 2005

N2 - Cacao polyphenols, catechins and procyanidins have attracted interest because of their possible effect on cardiovascular health. This paper provides an overview of our research on the effects of cocoa polyphenols on low-density lipoprotein (LDL) oxidizability and atherosclerosis. Polyphenol rich cocoa ingestion prolonged lag time (an index of LDL oxidative susceptibility) and decreased plasma oxidized LDL levels in humans and prevented atherosclerotic lesion formation in experimental animals. Catechins in cocoa show high bioavailability, and approximately 25-30% of ingested catechins are detectable in urine. After oral supplementation, they are present in blood as metabolites such as glucuronides and/or sulfate conjugated and/or methylated forms. The catechin metabolites (glucuronides) of rats and humans are structurally completely different, and their antioxidative activity is relatively maintained in rats but not in humans. On the other hand, ingestion of cacao products increased the level of HDL. The up-regulation of HDL might be shown antioxidative effect. Thus, cacao polyphenols may reduce cardiovascular disease risk.

AB - Cacao polyphenols, catechins and procyanidins have attracted interest because of their possible effect on cardiovascular health. This paper provides an overview of our research on the effects of cocoa polyphenols on low-density lipoprotein (LDL) oxidizability and atherosclerosis. Polyphenol rich cocoa ingestion prolonged lag time (an index of LDL oxidative susceptibility) and decreased plasma oxidized LDL levels in humans and prevented atherosclerotic lesion formation in experimental animals. Catechins in cocoa show high bioavailability, and approximately 25-30% of ingested catechins are detectable in urine. After oral supplementation, they are present in blood as metabolites such as glucuronides and/or sulfate conjugated and/or methylated forms. The catechin metabolites (glucuronides) of rats and humans are structurally completely different, and their antioxidative activity is relatively maintained in rats but not in humans. On the other hand, ingestion of cacao products increased the level of HDL. The up-regulation of HDL might be shown antioxidative effect. Thus, cacao polyphenols may reduce cardiovascular disease risk.

KW - Atherosclerosis

KW - Cacao polyphenols

KW - Catechins

KW - LDL

UR - http://www.scopus.com/inward/record.url?scp=33645782984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645782984&partnerID=8YFLogxK

U2 - 10.3164/jcbn.37.67

DO - 10.3164/jcbn.37.67

M3 - Article

AN - SCOPUS:33645782984

VL - 37

SP - 67

EP - 72

JO - Journal of Clinical Biochemistry and Nutrition

JF - Journal of Clinical Biochemistry and Nutrition

SN - 0912-0009

IS - 3

ER -