Carcinogenic risk of chromium, copper and arsenic in CCA-treated wood

Nobutaka Ohgami, Osamu Yamanoshita, Nguyen Dinh Thang, Ichiro Yajima, Chihiro Nakano, Wu Wenting, Shoko Ohnuma, Masashi Kato

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We showed that 2.1% of 233 pieces of lumber debris after the Great East Japan Earthquake was chromated copper arsenate (CCA)-treated wood. Since hexavalent chromium (Cr), copper (Cu) and pentavalent arsenic (As) in the debris may be diffused in the air via incineration, we exposed human lung normal (BEAS-2B) and carcinoma (A549) cells to Cr, Cu and As at the molar ratio in a representative CCA-treated wood. Co-exposure to 0.10 μM Cr and 0.06 μM As, which solely had no effect on colony formation, synergistically promoted colony formation in BEAS-2B cells, but not A549 cells, with activation of the PI3K/AKT pathway. Sole exposure and co-exposure to Cu showed limited effects. Since previous reports showed Cr and As concentrations to which human lungs might be exposed, our results suggest the importance to avoid diffusion of Cr and As in the air via incineration of debris including CCA-treated wood after the disaster.

Original languageEnglish
Pages (from-to)456-460
Number of pages5
JournalEnvironmental Pollution
Volume206
DOIs
Publication statusPublished - 2015 Aug 14
Externally publishedYes

Fingerprint

Arsenic
Chromium
Copper
Wood
Debris
Waste incineration
Lumber
Air
Phosphatidylinositol 3-Kinases
Disasters
Earthquakes
Chemical activation
chromated copper arsenate

Keywords

  • Arsenic
  • CCA-treated wood
  • Chromium
  • Copper
  • Debris
  • Great East Japan Earthquake

ASJC Scopus subject areas

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Ohgami, N., Yamanoshita, O., Thang, N. D., Yajima, I., Nakano, C., Wenting, W., ... Kato, M. (2015). Carcinogenic risk of chromium, copper and arsenic in CCA-treated wood. Environmental Pollution, 206, 456-460. https://doi.org/10.1016/j.envpol.2015.07.041

Carcinogenic risk of chromium, copper and arsenic in CCA-treated wood. / Ohgami, Nobutaka; Yamanoshita, Osamu; Thang, Nguyen Dinh; Yajima, Ichiro; Nakano, Chihiro; Wenting, Wu; Ohnuma, Shoko; Kato, Masashi.

In: Environmental Pollution, Vol. 206, 14.08.2015, p. 456-460.

Research output: Contribution to journalArticle

Ohgami, N, Yamanoshita, O, Thang, ND, Yajima, I, Nakano, C, Wenting, W, Ohnuma, S & Kato, M 2015, 'Carcinogenic risk of chromium, copper and arsenic in CCA-treated wood', Environmental Pollution, vol. 206, pp. 456-460. https://doi.org/10.1016/j.envpol.2015.07.041
Ohgami, Nobutaka ; Yamanoshita, Osamu ; Thang, Nguyen Dinh ; Yajima, Ichiro ; Nakano, Chihiro ; Wenting, Wu ; Ohnuma, Shoko ; Kato, Masashi. / Carcinogenic risk of chromium, copper and arsenic in CCA-treated wood. In: Environmental Pollution. 2015 ; Vol. 206. pp. 456-460.
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