Cardiovascular adaptation in response to chronic hypoxia in awake rats

Saki Hamashima, Masahiro Shibata

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

To examine how cardiovascular adaptation to chronic hypoxia might evolve, the responses to blood pressure (Pt) and hematocrit (Ht) during long-term systemic exposure to hypoxia were observed in awake rats. Furthermore, the total peripheral vascular resistance (TPR) was estimated using direct measurements of systemic blood pressure (Ps) and blood flow (Qs) in carotid artery based on Darcy’s law (TPR¼Ps/Qs) to evaluate the remodeling procedure in the microcirculation. BP and Ht under normoxic conditions were kept almost constant, while hypoxic exposure immediately increased Ht to 58% and, thereafter, it remained stable. The TPR values showed no significant differences between hypoxic and normoxic conditions. These results suggest that effects of high viscosity caused by increasing Ht on peripheral vascular resistance can be compensated by inducing microvascular remodeling with the arteriolar dilation and capillary angiogenesis.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages241-246
Number of pages6
Volume876
ISBN (Print)9781493930227
DOIs
Publication statusPublished - 2016
Event42nd Annual Meeting of International Society on Oxygen Transport to Tissue - London, United Kingdom
Duration: 2014 Jun 282014 Jul 3

Publication series

NameAdvances in Experimental Medicine and Biology
Volume876
ISSN (Print)00652598
ISSN (Electronic)22148019

Other

Other42nd Annual Meeting of International Society on Oxygen Transport to Tissue
CountryUnited Kingdom
CityLondon
Period14/6/2814/7/3

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Keywords

  • Awake rats
  • Hypoxia
  • Microvascular remodeling
  • Total peripheral vascular resistance

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Hamashima, S., & Shibata, M. (2016). Cardiovascular adaptation in response to chronic hypoxia in awake rats. In Advances in Experimental Medicine and Biology (Vol. 876, pp. 241-246). (Advances in Experimental Medicine and Biology; Vol. 876). Springer New York LLC. https://doi.org/10.1007/978-1-4939-3023-4_30