Catalytic asymmetric synthesis of optically active atropisomeric anilides through enantioselective N-allylation with chiral Pd-tol-BINAP catalyst

Osamu Kitagawa, Mitsuteru Kohriyama, Takeo Taguchi

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Abstract

Catalytic asymmetric N-allylation reaction of ortho-tert-butylanilide derivatives with diallyl carbonate proceeds in the presence of tol-BINAP-Pd catalyst to give chiral N-allyl ortho-tert-butylanilides of 32-44%ee in excellent chemical yields (≥ 90%).

Original languageEnglish
Pages (from-to)8682-8684
Number of pages3
JournalJournal of Organic Chemistry
Volume67
Issue number24
DOIs
Publication statusPublished - 2002 Nov 29
Externally publishedYes

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ASJC Scopus subject areas

  • Organic Chemistry

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