Catalytic enantioselective synthesis of key intermediates for NET inhibitors using atropisomeric lactam chemistry

Osamu Kitagawa, Daisuke Kurihara, Hajime Tanabe, Taichi Shibuya, Takeo Taguchi

Research output: Contribution to journal › Article

26 Citations (Scopus)

Abstract

An atropisomeric lactam which was prepared with high enantioselectivity by catalytic asymmetric intramolecular N-arylation, was efficiently converted to synthetic intermediates for NET inhibitors through highly diastereoselective α-alkylation followed by hydration and trans-tert-butylation.

Original languageEnglish
Pages (from-to)471-474
Number of pages4
JournalTetrahedron Letters
Volume49
Issue number3
DOIs
Publication statusPublished - 2008 Jan 14
Externally publishedYes

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Lactams
Enantioselectivity
Alkylation
Hydration

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Catalytic enantioselective synthesis of key intermediates for NET inhibitors using atropisomeric lactam chemistry. / Kitagawa, Osamu; Kurihara, Daisuke; Tanabe, Hajime; Shibuya, Taichi; Taguchi, Takeo.

In: Tetrahedron Letters, Vol. 49, No. 3, 14.01.2008, p. 471-474.

Research output: Contribution to journal › Article

Kitagawa, O, Kurihara, D, Tanabe, H, Shibuya, T & Taguchi, T 2008, 'Catalytic enantioselective synthesis of key intermediates for NET inhibitors using atropisomeric lactam chemistry', Tetrahedron Letters, vol. 49, no. 3, pp. 471-474. https://doi.org/10.1016/j.tetlet.2007.11.101
Kitagawa O, Kurihara D, Tanabe H, Shibuya T, Taguchi T. Catalytic enantioselective synthesis of key intermediates for NET inhibitors using atropisomeric lactam chemistry. Tetrahedron Letters. 2008 Jan 14;49(3):471-474. https://doi.org/10.1016/j.tetlet.2007.11.101
Kitagawa, Osamu ; Kurihara, Daisuke ; Tanabe, Hajime ; Shibuya, Taichi ; Taguchi, Takeo. / Catalytic enantioselective synthesis of key intermediates for NET inhibitors using atropisomeric lactam chemistry. In: Tetrahedron Letters. 2008 ; Vol. 49, No. 3. pp. 471-474.
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