Catalytic enantioselective synthesis of key intermediates for NET inhibitors using atropisomeric lactam chemistry

Osamu Kitagawa, Daisuke Kurihara, Hajime Tanabe, Taichi Shibuya, Takeo Taguchi

Research output: Contribution to journalArticle

26 Citations (Scopus)


An atropisomeric lactam which was prepared with high enantioselectivity by catalytic asymmetric intramolecular N-arylation, was efficiently converted to synthetic intermediates for NET inhibitors through highly diastereoselective α-alkylation followed by hydration and trans-tert-butylation.

Original languageEnglish
Pages (from-to)471-474
Number of pages4
JournalTetrahedron Letters
Issue number3
Publication statusPublished - 2008 Jan 14


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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