Catalytic enantioselective synthesis of key intermediates for NET inhibitors using atropisomeric lactam chemistry

Osamu Kitagawa; Daisuke Kurihara; Hajime Tanabe; Taichi Shibuya; Takeo Taguchi

doi:10.1016/j.tetlet.2007.11.101

Catalytic enantioselective synthesis of key intermediates for NET inhibitors using atropisomeric lactam chemistry

Osamu Kitagawa, Daisuke Kurihara, Hajime Tanabe, Taichi Shibuya, Takeo Taguchi

Research output: Contribution to journal › Article

26 Citations (Scopus)

Abstract

An atropisomeric lactam which was prepared with high enantioselectivity by catalytic asymmetric intramolecular N-arylation, was efficiently converted to synthetic intermediates for NET inhibitors through highly diastereoselective α-alkylation followed by hydration and trans-tert-butylation.

Original language	English
Pages (from-to)	471-474
Number of pages	4
Journal	Tetrahedron Letters
Volume	49
Issue number	3
DOIs	https://doi.org/10.1016/j.tetlet.2007.11.101
Publication status	Published - 2008 Jan 14

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Kitagawa, O., Kurihara, D., Tanabe, H., Shibuya, T., & Taguchi, T. (2008). Catalytic enantioselective synthesis of key intermediates for NET inhibitors using atropisomeric lactam chemistry. Tetrahedron Letters, 49(3), 471-474. https://doi.org/10.1016/j.tetlet.2007.11.101

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AU - Shibuya, Taichi

AU - Taguchi, Takeo

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