Abstract
N-C axially chiral phenanthridin-6-one derivatives bearing various ortho-substituted phenyl groups on the nitrogen atom were enantioselectively prepared through (R)-DTBM-SEGPHOS-Pd(OAc)2-catalyzed intramolecular Buchwald-Hartwig amination. The enantioselectivity strongly depended on solvents, bases, and reaction temperature as well as on the bulkiness of ortho-substituents.
Original language | English |
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Pages (from-to) | 318-323 |
Number of pages | 6 |
Journal | Journal of Organic Chemistry |
Volume | 81 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2016 Jan 4 |
ASJC Scopus subject areas
- Organic Chemistry