Abstract
In vitro effects of catechins and their oligomers linked by C4 → C8 bonds are major antioxidative components of chocolate and cocoa. Their effects on the susceptibility of human low-density lipoprotein (LDL) to oxidation were evaluated. The strength of the antioxidative activity was measured using copper ions as the radical generator as compared by weight varied in the following order: (+)-catechin > procyanidin B2 (-)epicatechin procyanidin C1 > cinnamtannin A2. Using 2,2′azobis (4-methoxy-2,4-dimethylvaleronitrile) (MeO-AMVN) as the radical generator, the order was (-)-epicatechin procyanidin B2 procyanidin C1 > (+)-catechin cinnamtannin A2. It is suggested that these compounds contribute to the activity of cacao products to protect LDL from oxidation.
| Original language | English |
|---|---|
| Pages (from-to) | 51-56 |
| Number of pages | 6 |
| Journal | Experimental Biology and Medicine |
| Volume | 227 |
| Issue number | 1 |
| Publication status | Published - 2002 Jan |
| Externally published | Yes |
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Keywords
- Cacao
- Catechin
- Copper
- LDL
- MeO-AMVN
- Procyanidin
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Catechins and their oligomers linked by C4 → C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro. / Osakabe, Naomi; Yasuda, Akiko; Natsume, Midori; Takizawa, Toshio; Terao, Junji; Kondo, Kazuo.
In: Experimental Biology and Medicine, Vol. 227, No. 1, 01.2002, p. 51-56.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Catechins and their oligomers linked by C4 → C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro
AU - Osakabe, Naomi
AU - Yasuda, Akiko
AU - Natsume, Midori
AU - Takizawa, Toshio
AU - Terao, Junji
AU - Kondo, Kazuo
PY - 2002/1
Y1 - 2002/1
N2 - In vitro effects of catechins and their oligomers linked by C4 → C8 bonds are major antioxidative components of chocolate and cocoa. Their effects on the susceptibility of human low-density lipoprotein (LDL) to oxidation were evaluated. The strength of the antioxidative activity was measured using copper ions as the radical generator as compared by weight varied in the following order: (+)-catechin > procyanidin B2 (-)epicatechin procyanidin C1 > cinnamtannin A2. Using 2,2′azobis (4-methoxy-2,4-dimethylvaleronitrile) (MeO-AMVN) as the radical generator, the order was (-)-epicatechin procyanidin B2 procyanidin C1 > (+)-catechin cinnamtannin A2. It is suggested that these compounds contribute to the activity of cacao products to protect LDL from oxidation.
AB - In vitro effects of catechins and their oligomers linked by C4 → C8 bonds are major antioxidative components of chocolate and cocoa. Their effects on the susceptibility of human low-density lipoprotein (LDL) to oxidation were evaluated. The strength of the antioxidative activity was measured using copper ions as the radical generator as compared by weight varied in the following order: (+)-catechin > procyanidin B2 (-)epicatechin procyanidin C1 > cinnamtannin A2. Using 2,2′azobis (4-methoxy-2,4-dimethylvaleronitrile) (MeO-AMVN) as the radical generator, the order was (-)-epicatechin procyanidin B2 procyanidin C1 > (+)-catechin cinnamtannin A2. It is suggested that these compounds contribute to the activity of cacao products to protect LDL from oxidation.
KW - Cacao
KW - Catechin
KW - Copper
KW - LDL
KW - MeO-AMVN
KW - Procyanidin
UR - http://www.scopus.com/inward/record.url?scp=0036375101&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036375101&partnerID=8YFLogxK
M3 - Article
C2 - 11788784
AN - SCOPUS:0036375101
VL - 227
SP - 51
EP - 56
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
SN - 0037-9727
IS - 1
ER -