Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice

Shota Ushiama, Yoshiro Ishimaru, Masataka Narukawa, Misako Yoshioka, Chisayo Kozuka, Naoki Watanabe, Makoto Tsunoda, Naomi Osakabe, Tomiko Asakura, Hiroaki Masuzaki, Keiko Abe

Research output: Research - peer-reviewArticle

  • 4 Citations

Abstract

Taste signals and nutrient stimuli sensed by the gastrointestinal tract are transmitted to the brain to regulate feeding behavior and energy homeostasis. This system is referred to as the gut-brain axis. Here we show that both brush cells and type II taste cells are eliminated in the gastrointestinal tract of transcription factor . Skn-1 knockout (KO) mice. Despite unaltered food intake, . Skn-1 KO mice have reduced body weight with lower body fat due to increased energy expenditure. In this model, 24-h urinary excretion of catecholamines was significantly elevated, accompanied by increased fatty acid β-oxidation and fuel dissipation in skeletal muscle and impaired insulin secretion driven by glucose. These results suggest the existence of brain-mediated energy homeostatic pathways originating from brush cells and type II taste cells in the gastrointestinal tract and ending in peripheral tissues, including the adrenal glands. The discovery of food-derived factors that regulate these cells may open new avenues the treatment of obesity and diabetes. Research Context: Taste signals and nutrient stimuli sensed by the gastrointestinal tract are transmitted to the brain to regulate feeding behavior and energy homeostasis along the gut-brain axis. We propose the concept that taste-receiving cells in the oral cavity and/or food-borne chemicals-receiving brush cells in the gut are involved in regulation of the body weight and adiposity via the brain. The discovery of food-derived factors that regulate these cells may open new avenues for the treatment of obesity and diabetes.

LanguageEnglish
JournalEBioMedicine
DOIs
StateAccepted/In press - 2016 Jan 25

Fingerprint

Catecholamines
Brain
Transcription Factors
Brushes
Medical problems
Nutrients
Muscle
Fatty Acids
Fats
Insulin
Tissue
Glucose
Oxidation
Energy Metabolism

Keywords

  • Brush cells
  • Catecholamine
  • Energy metabolism
  • Insulin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice. / Ushiama, Shota; Ishimaru, Yoshiro; Narukawa, Masataka; Yoshioka, Misako; Kozuka, Chisayo; Watanabe, Naoki; Tsunoda, Makoto; Osakabe, Naomi; Asakura, Tomiko; Masuzaki, Hiroaki; Abe, Keiko.

In: EBioMedicine, 25.01.2016.

Research output: Research - peer-reviewArticle

Ushiama, Shota ; Ishimaru, Yoshiro ; Narukawa, Masataka ; Yoshioka, Misako ; Kozuka, Chisayo ; Watanabe, Naoki ; Tsunoda, Makoto ; Osakabe, Naomi ; Asakura, Tomiko ; Masuzaki, Hiroaki ; Abe, Keiko. / Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice. In: EBioMedicine. 2016
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