Characterization of a novel member of the FGFR family, HrFGFR, in Halocynthia roretzi

Shuichi Kamei, Ichiro Yajima, Hiroaki Yamamoto, Ako Kobayashi, Kazuhiro W. Makabe, Hidetoshi Yamazaki, Shin Ichi Hayashi, Takahiro Kunisada

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The cDNA for a novel member of the FGFR family, named HrFGFR, was isolated from a Halocynthia roretzi cDNA library prepared at the mid-tailbud stage. This cDNA was 3507b long, and the deduced amino acid sequence contained a motif characteristic of the vertebrate FGFRs. The existence of a single copy of the FGFR homologue gene in H. roretzi was suggested by restriction site analysis of multiple clones. HrFGFR mRNA was expressed strongly in the posterior region in the epidermis from the middle neurula stage. By contrast, Xenopus FGFR homologues are expressed in the anterior region and are known to induce anterior neural formation. A transition of the region expressing FGFR might have induced the more complicated brain or head formation characteristic of vertebrates. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)503-508
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume275
Issue number2
DOIs
Publication statusPublished - 2000 Aug 28

Keywords

  • Ascidian
  • Fibroblast growth factor receptor
  • Gene duplication
  • Halocynthia roretzi
  • Protein tyrosine kinase

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Kamei, S., Yajima, I., Yamamoto, H., Kobayashi, A., Makabe, K. W., Yamazaki, H., Hayashi, S. I., & Kunisada, T. (2000). Characterization of a novel member of the FGFR family, HrFGFR, in Halocynthia roretzi. Biochemical and Biophysical Research Communications, 275(2), 503-508. https://doi.org/10.1006/bbrc.2000.3334