Chemoselective bromination of active methylene and methyne compounds by potassium bromide, hydrochloric acid and hydrogen peroxide

Masayuki Kirihara, Shiho Ogawa, Takuya Noguchi, Kumiko Okubo, Yoshinari Monma, Ikuko Shimizu, Ryuji Shimosaki, Akihiko Hatano, Yoshiro Hirai

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Active methylene and methyne compounds can be chemoselectively brominated in high yields using potassium bromide, hydrochloric acid, and hydrogen peroxide at room temperature.

Original languageEnglish
Pages (from-to)2287-2289
Number of pages3
JournalSynlett
Issue number14
DOIs
Publication statusPublished - 2006 Sep 1
Externally publishedYes

Keywords

  • Active methylene compounds
  • Bromination
  • Green chemistry
  • Halaides
  • Halogenation

ASJC Scopus subject areas

  • Organic Chemistry

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  • Cite this

    Kirihara, M., Ogawa, S., Noguchi, T., Okubo, K., Monma, Y., Shimizu, I., Shimosaki, R., Hatano, A., & Hirai, Y. (2006). Chemoselective bromination of active methylene and methyne compounds by potassium bromide, hydrochloric acid and hydrogen peroxide. Synlett, (14), 2287-2289. https://doi.org/10.1055/s-2006-948207