Chiral initiator-induces self-disproportionation of enantiomers via achiral chromatography: Application to enantiomer separation of racemate

Kaori Tateishi, Shiori Tsukagoshi, Tsuyoshi Nakamura, Shotaro Watanabe, Vadim A. Soloshonok, Osamu Kitagawa

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18 Citations (Scopus)

Abstract

We report here the theoretical design and proof of principle of the first example of a conceptually new approach for the preparation of enantiomerically pure compounds from the racemates by chiral initiator-induced Self-Disproportionation of Enantiomers (SDE) via achiral chromatography.

Original languageEnglish
Pages (from-to)5220-5223
Number of pages4
JournalTetrahedron Letters
Volume54
Issue number38
DOIs
Publication statusPublished - 2013 Sep 18

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Keywords

  • Association
  • Chromatography
  • Disproportionation
  • Enantiomers
  • Optical resolution

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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