Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice

Haruka Tamura, Nobutaka Ohgami, Ichiro Yajima, Machiko Iida, Kyoko Ohgami, Noriko Fujii, Hiroyuki Itabe, Tastuya Kusudo, Hitoshi Yamashita, Masashi Kato

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Abstract

We are routinely exposed to low frequency noise (LFN; below 0.5 kHz) at moderate levels of 60-70 dB sound pressure level (SPL) generated from various sources in occupational and daily environments. LFN has been reported to affect balance in humans. However, there is limited information about the influence of chronic exposure to LFN at moderate levels for balance. In this study, we investigated whether chronic exposure to LFN at a moderate level of 70 dB SPL affects the vestibule, which is one of the organs responsible for balance in mice. Wild-type ICR mice were exposed for 1 month to LFN (0.1 kHz) and high frequency noise (HFN; 16 kHz) at 70 dB SPL at a distance of approximately 10-20 cm. Behavior analyses including rotarod, beam-crossing and footprint analyses showed impairments of balance in LFN-exposed mice but not in non-exposed mice or HFN-exposed mice. Immunohistochemical analysis showed a decreased number of vestibular hair cells and increased levels of oxidative stress in LFN-exposed mice compared to those in non-exposed mice. Our results suggest that chronic exposure to LFN at moderate levels causes impaired balance involving morphological impairments of the vestibule with enhanced levels of oxidative stress. Thus, the results of this study indicate the importance of considering the risk of chronic exposure to LFN at a moderate level for imbalance.

Original languageEnglish
Article numbere39807
JournalPLoS ONE
Volume7
Issue number6
DOIs
Publication statusPublished - 2012 Jun 29

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Tamura, H., Ohgami, N., Yajima, I., Iida, M., Ohgami, K., Fujii, N., Itabe, H., Kusudo, T., Yamashita, H., & Kato, M. (2012). Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice. PLoS ONE, 7(6), [e39807]. https://doi.org/10.1371/journal.pone.0039807