Clinical features and medical treatments of toxic megacolon in seven patients with ulcerative colitis

Masaharu Tsuchiya, Kensuke Kobayashi, Sadakazu Aiso, Mamoru Watanabe, Takeshi Yoshida, Maki Ishikawa, Masahiro Yoshioka, Yoshiki Hamada, Hitoshi Asakura, Koshi Ando

Research output: Contribution to journalArticle

Abstract

We have experienced seven cases of toxic megacolon associated with ulcerative colitis, all of the cases being relapsing-remitting type. The laboratory data were characterized by anemia, hypoproteinemia and increased levels of fibrinogen and α2 globulin. Five patients were treated by a one-shot injection of 20-60 mg of prednisolone into the mesentric arteries, whereas two patients were given prednisolone intravenously. After these medical therapy, five of seven patients have been recuperated well into the remitting stage for up to seven years without any surgical intervention. From these data, intraarterial injection of prednisolone appears to be very effective means, among other therapy including surgery, in treating toxic megacolon.

Original languageEnglish
Pages (from-to)1735-1746
Number of pages12
JournalNippon Shokakibyo Gakkai Zasshi
Volume80
Issue number9
DOIs
Publication statusPublished - 1983 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Clinical features and medical treatments of toxic megacolon in seven patients with ulcerative colitis. / Tsuchiya, Masaharu; Kobayashi, Kensuke; Aiso, Sadakazu; Watanabe, Mamoru; Yoshida, Takeshi; Ishikawa, Maki; Yoshioka, Masahiro; Hamada, Yoshiki; Asakura, Hitoshi; Ando, Koshi.

In: Nippon Shokakibyo Gakkai Zasshi, Vol. 80, No. 9, 01.01.1983, p. 1735-1746.

Research output: Contribution to journalArticle

Tsuchiya, M, Kobayashi, K, Aiso, S, Watanabe, M, Yoshida, T, Ishikawa, M, Yoshioka, M, Hamada, Y, Asakura, H & Ando, K 1983, 'Clinical features and medical treatments of toxic megacolon in seven patients with ulcerative colitis', Nippon Shokakibyo Gakkai Zasshi, vol. 80, no. 9, pp. 1735-1746. https://doi.org/10.11405/nisshoshi1964.80.1735
Tsuchiya, Masaharu ; Kobayashi, Kensuke ; Aiso, Sadakazu ; Watanabe, Mamoru ; Yoshida, Takeshi ; Ishikawa, Maki ; Yoshioka, Masahiro ; Hamada, Yoshiki ; Asakura, Hitoshi ; Ando, Koshi. / Clinical features and medical treatments of toxic megacolon in seven patients with ulcerative colitis. In: Nippon Shokakibyo Gakkai Zasshi. 1983 ; Vol. 80, No. 9. pp. 1735-1746.
@article{087b9b23b238425988ddd90aa654c5e3,
title = "Clinical features and medical treatments of toxic megacolon in seven patients with ulcerative colitis",
abstract = "We have experienced seven cases of toxic megacolon associated with ulcerative colitis, all of the cases being relapsing-remitting type. The laboratory data were characterized by anemia, hypoproteinemia and increased levels of fibrinogen and α2 globulin. Five patients were treated by a one-shot injection of 20-60 mg of prednisolone into the mesentric arteries, whereas two patients were given prednisolone intravenously. After these medical therapy, five of seven patients have been recuperated well into the remitting stage for up to seven years without any surgical intervention. From these data, intraarterial injection of prednisolone appears to be very effective means, among other therapy including surgery, in treating toxic megacolon.",
author = "Masaharu Tsuchiya and Kensuke Kobayashi and Sadakazu Aiso and Mamoru Watanabe and Takeshi Yoshida and Maki Ishikawa and Masahiro Yoshioka and Yoshiki Hamada and Hitoshi Asakura and Koshi Ando",
year = "1983",
month = "1",
day = "1",
doi = "10.11405/nisshoshi1964.80.1735",
language = "English",
volume = "80",
pages = "1735--1746",
journal = "Japanese Journal of Gastroenterology",
issn = "0446-6586",
publisher = "Japanese Society of Gastroenterology",
number = "9",

}

TY - JOUR

T1 - Clinical features and medical treatments of toxic megacolon in seven patients with ulcerative colitis

AU - Tsuchiya, Masaharu

AU - Kobayashi, Kensuke

AU - Aiso, Sadakazu

AU - Watanabe, Mamoru

AU - Yoshida, Takeshi

AU - Ishikawa, Maki

AU - Yoshioka, Masahiro

AU - Hamada, Yoshiki

AU - Asakura, Hitoshi

AU - Ando, Koshi

PY - 1983/1/1

Y1 - 1983/1/1

N2 - We have experienced seven cases of toxic megacolon associated with ulcerative colitis, all of the cases being relapsing-remitting type. The laboratory data were characterized by anemia, hypoproteinemia and increased levels of fibrinogen and α2 globulin. Five patients were treated by a one-shot injection of 20-60 mg of prednisolone into the mesentric arteries, whereas two patients were given prednisolone intravenously. After these medical therapy, five of seven patients have been recuperated well into the remitting stage for up to seven years without any surgical intervention. From these data, intraarterial injection of prednisolone appears to be very effective means, among other therapy including surgery, in treating toxic megacolon.

AB - We have experienced seven cases of toxic megacolon associated with ulcerative colitis, all of the cases being relapsing-remitting type. The laboratory data were characterized by anemia, hypoproteinemia and increased levels of fibrinogen and α2 globulin. Five patients were treated by a one-shot injection of 20-60 mg of prednisolone into the mesentric arteries, whereas two patients were given prednisolone intravenously. After these medical therapy, five of seven patients have been recuperated well into the remitting stage for up to seven years without any surgical intervention. From these data, intraarterial injection of prednisolone appears to be very effective means, among other therapy including surgery, in treating toxic megacolon.

UR - http://www.scopus.com/inward/record.url?scp=0020816651&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020816651&partnerID=8YFLogxK

U2 - 10.11405/nisshoshi1964.80.1735

DO - 10.11405/nisshoshi1964.80.1735

M3 - Article

VL - 80

SP - 1735

EP - 1746

JO - Japanese Journal of Gastroenterology

JF - Japanese Journal of Gastroenterology

SN - 0446-6586

IS - 9

ER -