Clinical features and medical treatments of toxic megacolon in seven patients with ulcerative colitis

Masaharu Tsuchiya, Kensuke Kobayashi, Sadakazu Aiso, Mamoru Watanabe, Takeshi Yoshida, Maki Ishikawa, Masahiro Yoshioka, Yoshiki Hamada, Hitoshi Asakura, Koshi Ando

Research output: Contribution to journalArticle

Abstract

We have experienced seven cases of toxic megacolon associated with ulcerative colitis, all of the cases being relapsing-remitting type. The laboratory data were characterized by anemia, hypoproteinemia and increased levels of fibrinogen and α2 globulin. Five patients were treated by a one-shot injection of 20-60 mg of prednisolone into the mesentric arteries, whereas two patients were given prednisolone intravenously. After these medical therapy, five of seven patients have been recuperated well into the remitting stage for up to seven years without any surgical intervention. From these data, intraarterial injection of prednisolone appears to be very effective means, among other therapy including surgery, in treating toxic megacolon.

Original languageEnglish
Pages (from-to)1735-1746
Number of pages12
JournalNippon Shokakibyo Gakkai Zasshi
Volume80
Issue number9
DOIs
Publication statusPublished - 1983 Jan

ASJC Scopus subject areas

  • Gastroenterology

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    Tsuchiya, M., Kobayashi, K., Aiso, S., Watanabe, M., Yoshida, T., Ishikawa, M., Yoshioka, M., Hamada, Y., Asakura, H., & Ando, K. (1983). Clinical features and medical treatments of toxic megacolon in seven patients with ulcerative colitis. Nippon Shokakibyo Gakkai Zasshi, 80(9), 1735-1746. https://doi.org/10.11405/nisshoshi1964.80.1735