Cloning and expression of a human/mouse polycomb group gene, ENX-2/Enx- 2

Motoyuki Ogawa, Yoshiki Hiraoka, Koji Taniguchi, Sadakazu Aiso

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The Drosophila Polycomb group (Pc-G) genes encode transcriptional factors involved in development. Little is known about members of the vertebrate Pc-G genes. In this study, we have isolated a cDNA encoding a human Pc-G protein and the mouse equivalent. The human and mouse genes, which were named ENX-2 and Enx-2, encode 702 and 750 amino acids, respectively. ENX-2/Enx-2 protein exhibits a high homology (53-55% identity) to Drosophila Enhancer of zeste [E(z)] protein belonging to the Pc-G. The expression of Enx-2 was observed in mouse kidney, adrenal gland, testis and brain at high levels by Northern blot analysis. A cell line of mouse neuroblastoma, Neuro- 2a, also expresses Enx-2 mRNA and its level is elevated by induction of neuronal differentiation of the cell.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1395
Issue number2
DOIs
Publication statusPublished - 1998 Jan 21

Keywords

  • Development
  • Enhancer of zeste
  • Hematopoietic cell
  • Neuro-2a
  • Neuronal differentiation

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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